PRJNA207719: Tissue specific transcriptome profiling


Results for hmx4

Z-value: 1.64

Motif logo

Transcription factors associated with hmx4

Gene Symbol Gene ID Gene Info
ENSDARG00000007941 H6 family homeobox 4
ENSDARG00000115000 H6 family homeobox 4
ENSDARG00000116208 H6 family homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of hmx4 motif

Sorted Z-values of hmx4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_233143 2.44 ENSDART00000175273
synaptic Ras GTPase activating protein 1a
chr1_-_14234076 1.55 ENSDART00000040049
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2
chr1_-_14233815 1.34 ENSDART00000044896
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2
chr16_-_26074529 1.22 ENSDART00000148653
transmembrane protein 145
chr8_+_7144066 1.21 ENSDART00000146306
solute carrier family 6 (neurotransmitter transporter), member 6a
chr2_-_49978227 1.14 ENSDART00000142835
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1b
chr9_-_44642108 1.13 ENSDART00000086202
phosphodiesterase 1A, calmodulin-dependent
chr18_-_46763170 1.10 ENSDART00000171880
delta/notch-like EGF repeat containing
chr15_+_19544052 1.09 ENSDART00000062560
chr1_+_8662530 1.09 ENSDART00000054989
fascin actin-bundling protein 1b
chr22_-_26945493 1.07 ENSDART00000077411
chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)
chr12_-_10220036 1.07 ENSDART00000134619
membrane protein, palmitoylated 2b (MAGUK p55 subfamily member 2)
chr21_-_23475361 0.98 ENSDART00000156658
neural cell adhesion molecule 1a
chr23_+_44307996 0.90 ENSDART00000042430
discs, large homolog 4b (Drosophila)
chr18_+_39067575 0.89 ENSDART00000077724
guanine nucleotide binding protein (G protein), beta 5b
chr3_-_5067585 0.87 ENSDART00000169609
thyrotrophic embryonic factor b
chr2_-_21352101 0.86 ENSDART00000057021
hedgehog acyltransferase like, a
chr16_+_5774977 0.86 ENSDART00000134202
cholecystokinin a
chr20_-_32112818 0.84 ENSDART00000142653
glutamate receptor, metabotropic 1a
chr20_-_28698172 0.83 ENSDART00000190635
signal-induced proliferation-associated 1 like 1
chr2_-_1279387 0.80 ENSDART00000192210

chr15_-_27710513 0.80 ENSDART00000005641
LIM homeobox 1a
chr6_-_8277221 0.80 ENSDART00000053869
solute carrier family 44 (choline transporter), member 2
chr13_+_22659153 0.79 ENSDART00000143906
synuclein, gamma a
chr9_+_38888025 0.79 ENSDART00000148306
microtubule-associated protein 2
chr3_-_30061985 0.76 ENSDART00000189583
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr6_+_59967994 0.76 ENSDART00000050457
chr23_+_19564392 0.76 ENSDART00000144746
ATPase H+ transporting accessory protein 1 like b
chr14_+_33722950 0.75 ENSDART00000075312
chr25_-_225964 0.75 ENSDART00000193424

chr1_+_59154521 0.75 ENSDART00000130089
heme-binding protein soul5, like
chr19_+_12762887 0.74 ENSDART00000139909
melanocortin 5a receptor
chr9_+_34380299 0.74 ENSDART00000131705
lysosomal-associated membrane protein 1
chr6_+_39836474 0.73 ENSDART00000112637
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
chr9_+_4252839 0.72 ENSDART00000169740
kalirin RhoGEF kinase a
chr1_-_25911292 0.72 ENSDART00000145012
ubiquitin specific peptidase 53b
chr5_-_46273938 0.70 ENSDART00000080033
chr3_-_22191132 0.69 ENSDART00000154226
microtubule-associated protein tau b
chr12_-_17810543 0.69 ENSDART00000090484
tectonin beta-propeller repeat containing 1a
chr16_-_27138478 0.69 ENSDART00000147438
transmembrane protein 245
chr17_-_16133249 0.68 ENSDART00000030919
prepronociceptin a
chr18_-_14941840 0.68 ENSDART00000091729
megalencephalic leukoencephalopathy with subcortical cysts 1
chr20_-_29418620 0.67 ENSDART00000172634
ryanodine receptor 3
chr5_-_64431927 0.67 ENSDART00000158248
bromodomain containing 3b
chr3_+_54012708 0.66 ENSDART00000154542
olfactomedin 2a
chr23_+_13721826 0.66 ENSDART00000142494
zinc finger and BTB domain containing 46
chr5_-_33460959 0.64 ENSDART00000085636
chr22_-_12160283 0.63 ENSDART00000146785
transmembrane protein 163b
chr21_+_9628854 0.63 ENSDART00000161753
mitogen-activated protein kinase 10
chr4_+_10017049 0.62 ENSDART00000144175
coiled-coil domain containing 136b
chr13_-_33822550 0.62 ENSDART00000143703
fibronectin leucine rich transmembrane 3
chr1_-_45889820 0.60 ENSDART00000144735
patatin-like phospholipase domain containing 6
chr21_+_34167178 0.59 ENSDART00000158308
transient receptor potential cation channel, subfamily C, member 5b
chr16_+_46148990 0.59 ENSDART00000083919
synaptic vesicle glycoprotein 2A
chr4_+_3287819 0.59 ENSDART00000168633

chr6_-_40744720 0.58 ENSDART00000154916
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr13_-_992458 0.57 ENSDART00000114655
beaded filament structural protein 1
chr6_+_32382743 0.57 ENSDART00000190009
dedicator of cytokinesis 7
chr10_-_43655449 0.56 ENSDART00000099134
myocyte enhancer factor 2ca
chr23_+_21566828 0.55 ENSDART00000134741
Rho guanine nucleotide exchange factor (GEF) 10-like b
chr13_-_40120252 0.55 ENSDART00000157852
cartilage acidic protein 1b
chr1_+_38776294 0.55 ENSDART00000170546
WD repeat domain 17
chr6_+_32497493 0.55 ENSDART00000184819
KN motif and ankyrin repeat domains 4
chr19_-_13774502 0.55 ENSDART00000159711
erythrocyte membrane protein band 4.1a
chr8_+_1651821 0.54 ENSDART00000060865
RAS protein activator like 1b (GAP1 like)
chr22_+_39074688 0.54 ENSDART00000153547
inositol hexakisphosphate kinase 1
chr19_+_30633453 0.54 ENSDART00000052124
family with sequence similarity 49, member A-like
chr12_+_21299338 0.54 ENSDART00000074540
carbonic anhydrase Xa
chr24_+_80653 0.53 ENSDART00000158473
reversion-inducing-cysteine-rich protein with kazal motifs
chr14_-_34044369 0.53 ENSDART00000149396
cytoplasmic FMR1 interacting protein 2
chr7_+_19552381 0.53 ENSDART00000169060
chr2_-_11662851 0.52 ENSDART00000145108
chr13_-_36545258 0.51 ENSDART00000186171

chr3_-_22829710 0.51 ENSDART00000055659
cytochrome b561
chr25_-_6082509 0.51 ENSDART00000104755
cytoplasmic polyadenylation element binding protein 1a
chr18_+_50275933 0.51 ENSDART00000143911
chr17_-_38887424 0.51 ENSDART00000141177
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4a
chr5_+_16117871 0.51 ENSDART00000090657
zinc and ring finger 3
chr14_+_8275115 0.50 ENSDART00000129055
neuregulin 2b
chr9_-_29427576 0.50 ENSDART00000065929
heparan sulfate 6-O-sulfotransferase 3b
chr18_+_50276653 0.50 ENSDART00000192120
chr12_+_19036380 0.50 ENSDART00000153086
potassium channel tetramerization domain containing 17
chr3_-_28209001 0.50 ENSDART00000151178
RNA binding fox-1 homolog 1
chr3_+_16265924 0.49 ENSDART00000122519
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
chr10_-_26793448 0.49 ENSDART00000141955
MCF.2 cell line derived transforming sequence b
chr7_-_18168493 0.49 ENSDART00000127428
pellino E3 ubiquitin protein ligase family member 3
chr17_-_15657029 0.49 ENSDART00000153925
fucosyltransferase 9a
chr23_-_35347714 0.48 ENSDART00000161770
copine family member IX
chr21_+_31838386 0.48 ENSDART00000135591
chr19_+_5604241 0.48 ENSDART00000011025
WAS/WASL interacting protein family, member 2b
chr8_-_32497815 0.48 ENSDART00000122359
chr20_-_29420713 0.47 ENSDART00000147464
ryanodine receptor 3
chr23_-_30076950 0.47 ENSDART00000180139
calmodulin binding transcription activator 1a
chr19_+_23932259 0.47 ENSDART00000139040
chr8_+_8532407 0.46 ENSDART00000169276
glutamate receptor, metabotropic 6a
chr9_+_46644633 0.46 ENSDART00000160285
solute carrier family 4 (anion exchanger), member 3
chr3_-_18373425 0.46 ENSDART00000178522
sperm associated antigen 9a
chr3_+_59784632 0.45 ENSDART00000084729
platelet/endothelial cell adhesion molecule 1
chr3_-_28750495 0.45 ENSDART00000054408
chr2_-_48375342 0.44 ENSDART00000148788
period circadian clock 2
chr18_+_50276337 0.44 ENSDART00000140352
chr13_+_3667230 0.44 ENSDART00000131553
QKI, KH domain containing, RNA binding b
chr13_+_16342926 0.43 ENSDART00000105496
discs, large homolog 5a (Drosophila)
chr8_-_32497581 0.43 ENSDART00000176298
chr9_-_47472998 0.42 ENSDART00000134480
tensin 1b
chr9_+_40874194 0.42 ENSDART00000141548
3-hydroxyisobutyryl-CoA hydrolase
chr11_+_30161699 0.42 ENSDART00000190504
cyclin-dependent kinase-like 5
chr7_+_25858380 0.42 ENSDART00000148780
myotubularin related protein 1a
chr1_-_25438934 0.42 ENSDART00000111686
FH2 domain containing 1
chr6_-_12135741 0.42 ENSDART00000155090
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1a
chr11_+_30162407 0.42 ENSDART00000190333
cyclin-dependent kinase-like 5
chr16_+_32559821 0.42 ENSDART00000093250
POU class 3 homeobox 2b
chr15_+_20548212 0.41 ENSDART00000193519
small G protein signaling modulator 2
chr5_+_31860043 0.41 ENSDART00000036235
iron-sulfur cluster assembly enzyme b
chr13_-_2520843 0.41 ENSDART00000187313
COX20 cytochrome c oxidase assembly factor
chr12_+_26621906 0.41 ENSDART00000158440
Rho GTPase activating protein 12b
chr12_-_33357655 0.41 ENSDART00000066233
solute carrier family 16 (monocarboxylate transporter), member 3
chr17_+_23937262 0.41 ENSDART00000113276
chr8_+_68864 0.41 ENSDART00000164574
proline rich 16
chr2_+_53359234 0.40 ENSDART00000147581
cugbp, Elav-like family member 5b
chr2_-_36925561 0.40 ENSDART00000187690
microtubule-associated protein 1Sb
chr13_+_31144305 0.39 ENSDART00000189602

chr21_-_37650271 0.39 ENSDART00000172087
Nedd4 family interacting protein 1, like
chr23_+_2560005 0.38 ENSDART00000186906
gamma-glutamyltransferase 7
chr2_+_20331445 0.38 ENSDART00000186880
phospholipid phosphatase related 4a
chr15_-_47193564 0.37 ENSDART00000172453
limbic system-associated membrane protein
chr8_-_43997538 0.37 ENSDART00000186449
RIMS binding protein 2
chr17_-_5769196 0.37 ENSDART00000113885
chr21_+_20949976 0.37 ENSDART00000135342
5-hydroxytryptamine (serotonin) receptor 1A b
chr3_+_37827373 0.37 ENSDART00000039517
acid-sensing (proton-gated) ion channel 2
chr22_-_14367966 0.36 ENSDART00000188796
low density lipoprotein receptor-related protein 1Ba
chr16_-_28709874 0.36 ENSDART00000127753
ADAM metallopeptidase domain 15
chr17_+_27723490 0.36 ENSDART00000123588
QKI, KH domain containing, RNA binding a
chr23_+_27789795 0.36 ENSDART00000141458
lysine (K)-specific methyltransferase 2D
chr18_-_6460102 0.35 ENSDART00000137037
IQ motif and Sec7 domain 3b
chr7_+_33279108 0.35 ENSDART00000084530
coronin, actin binding protein, 2Ba
chr15_+_32297441 0.35 ENSDART00000153657
tripartite motif containing 3a
chr3_-_19200571 0.35 ENSDART00000131503
regulatory factor X, 1a (influences HLA class II expression)
chr8_+_52619365 0.35 ENSDART00000162953
cysteine-rich, angiogenic inducer, 61 like 2
chr24_-_29030641 0.34 ENSDART00000156643
chr3_+_62356578 0.34 ENSDART00000157030
IQ motif containing K
chr15_-_31516558 0.34 ENSDART00000156427
high mobility group box 1b
chr9_+_8761099 0.34 ENSDART00000159077
collagen, type IV, alpha 2
chr9_-_23217196 0.34 ENSDART00000083567
kinesin family member 5C
chr13_-_361196 0.33 ENSDART00000093160
chr9_+_28688574 0.33 ENSDART00000101319
chr17_+_27434626 0.33 ENSDART00000052446
vestigial-like family member 2b
chr4_-_4119396 0.32 ENSDART00000067409
leiomodin 2 (cardiac) b
chr13_-_36525982 0.32 ENSDART00000114744
phosphofurin acidic cluster sorting protein 2
chr15_+_22867174 0.32 ENSDART00000035812
glutamate receptor, ionotropic, kainate 4
chr25_-_36020344 0.32 ENSDART00000181448
retinoblastoma-like 2 (p130)
chr14_+_33723309 0.32 ENSDART00000132488
chr4_+_14717502 0.32 ENSDART00000067031
potassium inwardly-rectifying channel, subfamily J, member 8
chr1_+_10378706 0.32 ENSDART00000046283
dachshund b
chr8_+_23916647 0.32 ENSDART00000143152
copine Va
chr7_+_74141297 0.31 ENSDART00000164992
RNA binding protein with multiple splicing
chr17_-_3291369 0.31 ENSDART00000181840

chr3_+_37824268 0.31 ENSDART00000137038
acid-sensing (proton-gated) ion channel 2
chr2_-_11512819 0.31 ENSDART00000142013
proenkephalin a
chr18_+_5549672 0.31 ENSDART00000184970
nicotinamide nucleotide transhydrogenase 2
chr7_-_1348640 0.31 ENSDART00000130012
receptor-interacting serine-threonine kinase 3
chr13_-_30700460 0.31 ENSDART00000139073
Ras association (RalGDS/AF-6) domain family member 4
chr1_+_45839927 0.30 ENSDART00000148086
mitogen-activated protein kinase kinase 7
chr16_+_20738740 0.30 ENSDART00000079343
JAZF zinc finger 1b
chr1_-_10841348 0.30 ENSDART00000148305
chr5_-_12407194 0.30 ENSDART00000125291
kinase suppressor of ras 2
chr5_+_16496273 0.30 ENSDART00000168969
5-hydroxytryptamine (serotonin) receptor 7c
chr14_-_2221877 0.30 ENSDART00000106704
protocadherin 2 alpha b 1
chr17_+_5768608 0.30 ENSDART00000157039
retinitis pigmentosa 1-like 1a
chr1_-_714626 0.29 ENSDART00000161072
ADAM metallopeptidase with thrombospondin type 1 motif 5
chr13_+_51869025 0.29 ENSDART00000187066

chr18_-_39583601 0.29 ENSDART00000125116
tumor necrosis factor, alpha-induced protein 8-like 3
chr2_+_15776649 0.29 ENSDART00000156535
vav 3 guanine nucleotide exchange factor b
chr15_+_21276735 0.29 ENSDART00000111213
ubiquitin associated and SH3 domain containing Bb
chr17_-_25395395 0.28 ENSDART00000170233
family with sequence similarity 167, member B
chr2_+_15776156 0.28 ENSDART00000190795
vav 3 guanine nucleotide exchange factor b
chr24_+_27268001 0.28 ENSDART00000122639
vasoactive intestinal peptide receptor 2
chr2_+_28453338 0.28 ENSDART00000020456
matrix metallopeptidase 15b
chr1_-_20970266 0.28 ENSDART00000088545
kelch-like family member 2
chr7_-_22632938 0.27 ENSDART00000159867
chr6_+_58406014 0.27 ENSDART00000044241
potassium voltage-gated channel, KQT-like subfamily, member 2b
chr8_+_43016714 0.27 ENSDART00000142671
Ras association (RalGDS/AF-6) domain family member 2a
chr6_-_11523987 0.26 ENSDART00000189363
GULP, engulfment adaptor PTB domain containing 1b
chr1_+_26356360 0.26 ENSDART00000113020
tet methylcytosine dioxygenase 2
chr12_-_26415499 0.26 ENSDART00000185779
synaptopodin 2-like b
chr3_-_60571218 0.26 ENSDART00000178981
chr10_-_7347311 0.26 ENSDART00000168885
neuregulin 1
chr2_+_58008980 0.25 ENSDART00000171264
chr20_-_16078741 0.25 ENSDART00000021550
Ral GEF with PH domain and SH3 binding motif 2
chr19_+_42716542 0.25 ENSDART00000144557
cytoplasmic linker associated protein 2
chr1_-_45584407 0.24 ENSDART00000149155
activating transcription factor 7 interacting protein
chr21_-_37790727 0.24 ENSDART00000162907
gamma-aminobutyric acid (GABA) A receptor, beta 4
chr17_-_20430177 0.24 ENSDART00000114236
sortilin related VPS10 domain containing receptor 3b
chr1_-_31140096 0.24 ENSDART00000172243
potassium voltage-gated channel, KQT-like subfamily, member 5b
chr23_+_22335407 0.24 ENSDART00000147696
RAP1 GTPase activating protein
chr9_-_21231297 0.24 ENSDART00000162578
phospholipase A1 member A
chr4_-_17263210 0.24 ENSDART00000147853
lymphoid-restricted membrane protein
chr22_-_16758438 0.24 ENSDART00000132829
PATJ, crumbs cell polarity complex component
chr4_+_5741733 0.23 ENSDART00000110243
POU class 3 homeobox 2a
chr1_-_25438737 0.23 ENSDART00000134470
FH2 domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of hmx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0014014 negative regulation of gliogenesis(GO:0014014)
0.3 1.0 GO:0021961 posterior commissure morphogenesis(GO:0021961)
0.3 0.9 GO:0060254 N-terminal protein palmitoylation(GO:0006500) negative regulation of lipoprotein metabolic process(GO:0050748) regulation of N-terminal protein palmitoylation(GO:0060254) negative regulation of N-terminal protein palmitoylation(GO:0060262) negative regulation of protein lipidation(GO:1903060)
0.3 1.1 GO:0021730 trigeminal sensory nucleus development(GO:0021730)
0.3 0.8 GO:0060688 regulation of morphogenesis of a branching structure(GO:0060688) positive regulation of mesonephros development(GO:0061213) regulation of mesonephros development(GO:0061217) regulation of kidney development(GO:0090183) positive regulation of kidney development(GO:0090184) regulation of branching involved in ureteric bud morphogenesis(GO:0090189) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190) interneuron axon guidance(GO:0097376) spinal cord interneuron axon guidance(GO:0097377) dorsal spinal cord interneuron axon guidance(GO:0097378)
0.2 0.7 GO:1905048 regulation of metallopeptidase activity(GO:1905048)
0.2 0.8 GO:0015871 choline transport(GO:0015871)
0.2 0.6 GO:0036076 ligamentous ossification(GO:0036076)
0.2 1.1 GO:0090134 mesendoderm migration(GO:0090133) cell migration involved in mesendoderm migration(GO:0090134)
0.2 0.5 GO:0045724 positive regulation of cilium assembly(GO:0045724)
0.1 0.9 GO:0072578 neurotransmitter-gated ion channel clustering(GO:0072578)
0.1 1.1 GO:2000650 negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.1 0.5 GO:0032801 receptor catabolic process(GO:0032801)
0.1 0.5 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.1 0.3 GO:0090493 synaptic transmission, dopaminergic(GO:0001963) norepinephrine transport(GO:0015874) dopamine uptake involved in synaptic transmission(GO:0051583) catecholamine uptake involved in synaptic transmission(GO:0051934) catecholamine uptake(GO:0090493) dopamine uptake(GO:0090494)
0.1 0.3 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) Schwann cell migration(GO:0036135) cardiac neuron differentiation(GO:0060945) cardiac neuron development(GO:0060959)
0.1 0.2 GO:0035046 pronuclear migration(GO:0035046)
0.1 0.3 GO:0006740 NADPH regeneration(GO:0006740)
0.1 0.4 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.1 0.4 GO:0006574 valine catabolic process(GO:0006574)
0.1 0.5 GO:0019857 5-methylcytosine catabolic process(GO:0006211) 5-methylcytosine metabolic process(GO:0019857)
0.1 0.2 GO:0007414 axonal defasciculation(GO:0007414)
0.1 0.5 GO:0021628 olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)
0.1 0.7 GO:0034394 protein localization to cell surface(GO:0034394)
0.1 0.7 GO:0010996 response to auditory stimulus(GO:0010996)
0.1 0.5 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.2 GO:0006089 lactate metabolic process(GO:0006089)
0.1 0.2 GO:0021985 neurohypophysis development(GO:0021985)
0.1 0.7 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.1 0.5 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.5 GO:0001964 startle response(GO:0001964)
0.0 0.3 GO:0098935 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.0 0.4 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.2 GO:0070129 regulation of mitochondrial translation(GO:0070129) positive regulation of mitochondrial translation(GO:0070131)
0.0 0.2 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.6 GO:0006991 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.6 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.0 0.8 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.0 0.8 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.0 0.4 GO:0003428 growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428)
0.0 0.5 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.8 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 1.0 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.3 GO:0072595 maintenance of protein localization in organelle(GO:0072595)
0.0 1.2 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 1.2 GO:0072348 sulfur compound transport(GO:0072348)
0.0 0.2 GO:0035176 social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.0 1.1 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.0 0.1 GO:0071387 cellular response to cortisol stimulus(GO:0071387) response to dexamethasone(GO:0071548)
0.0 0.6 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.0 0.5 GO:0036065 fucosylation(GO:0036065)
0.0 0.1 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 0.5 GO:0086001 cardiac muscle cell action potential(GO:0086001)
0.0 0.1 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.0 0.1 GO:0006004 fucose metabolic process(GO:0006004)
0.0 0.2 GO:0060420 regulation of heart growth(GO:0060420)
0.0 0.5 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.3 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.2 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.6 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.4 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.1 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.0 0.2 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 0.0 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.1 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.0 0.2 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 0.4 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.9 GO:0007586 digestion(GO:0007586)
0.0 0.4 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.8 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 0.4 GO:0050795 regulation of behavior(GO:0050795)
0.0 0.4 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.0 0.2 GO:0006346 methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.5 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.0 0.2 GO:0045762 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.0 1.4 GO:0051017 actin filament bundle assembly(GO:0051017)
0.0 0.1 GO:0000455 enzyme-directed rRNA pseudouridine synthesis(GO:0000455)
0.0 0.9 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.3 GO:1901222 regulation of NIK/NF-kappaB signaling(GO:1901222)
0.0 0.4 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.0 0.6 GO:0036269 swimming behavior(GO:0036269)
0.0 1.1 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.3 GO:1902807 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.8 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.8 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.9 GO:0071482 cellular response to light stimulus(GO:0071482)
0.0 0.1 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 0.4 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.6 GO:0007254 JNK cascade(GO:0007254)
0.0 0.0 GO:0035521 monoubiquitinated protein deubiquitination(GO:0035520) monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.0 0.1 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 1.5 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0 0.0 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.2 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.7 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.0 0.1 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 0.3 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.4 GO:0031398 positive regulation of protein ubiquitination(GO:0031398)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.2 0.7 GO:1990909 Wnt signalosome(GO:1990909)
0.2 1.1 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 0.8 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.1 0.3 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 0.2 GO:0030062 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.1 0.4 GO:0005784 Sec61 translocon complex(GO:0005784)
0.0 1.8 GO:0043679 axon terminus(GO:0043679)
0.0 0.1 GO:0031251 PAN complex(GO:0031251)
0.0 0.7 GO:0071564 npBAF complex(GO:0071564)
0.0 0.6 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.3 GO:0043194 axon initial segment(GO:0043194)
0.0 0.6 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.9 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.1 GO:0042709 succinate-CoA ligase complex(GO:0042709)
0.0 0.5 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 1.1 GO:0030426 growth cone(GO:0030426)
0.0 0.8 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 0.4 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.7 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.1 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.1 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 1.8 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0070390 transcription export complex 2(GO:0070390)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.1 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.6 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.2 GO:0045180 basal cortex(GO:0045180)
0.0 0.2 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0031704 apelin receptor binding(GO:0031704)
0.3 0.8 GO:1903136 cuprous ion binding(GO:1903136)
0.2 1.1 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.2 0.8 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.2 0.5 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.1 0.8 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.1 0.6 GO:0010858 calcium-dependent protein kinase inhibitor activity(GO:0008427) calcium-dependent protein kinase regulator activity(GO:0010858)
0.1 0.3 GO:0005330 dopamine transmembrane transporter activity(GO:0005329) dopamine:sodium symporter activity(GO:0005330) norepinephrine transmembrane transporter activity(GO:0005333) norepinephrine:sodium symporter activity(GO:0005334)
0.1 0.7 GO:0004977 melanocortin receptor activity(GO:0004977)
0.1 0.5 GO:0008432 JUN kinase binding(GO:0008432)
0.1 1.1 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 0.5 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1 0.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.3 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 0.4 GO:0050699 WW domain binding(GO:0050699)
0.1 1.0 GO:0031628 opioid receptor binding(GO:0031628)
0.1 0.5 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.1 0.5 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.1 0.6 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 0.5 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 0.3 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.1 2.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 0.2 GO:0019777 Atg12 transferase activity(GO:0019777)
0.1 0.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.7 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.1 0.5 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 0.4 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 1.1 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.5 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.6 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0 0.3 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.1 GO:0000035 acyl binding(GO:0000035)
0.0 1.0 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.3 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.6 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.0 0.5 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.1 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.0 1.2 GO:0005343 organic acid:sodium symporter activity(GO:0005343)
0.0 0.6 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.5 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.0 0.3 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.1 GO:0004774 succinate-CoA ligase activity(GO:0004774) succinate-CoA ligase (ADP-forming) activity(GO:0004775) succinate-CoA ligase (GDP-forming) activity(GO:0004776)
0.0 0.5 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.7 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.2 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 0.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.1 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 0.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.1 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.0 0.1 GO:0047777 (3S)-citramalyl-CoA lyase activity(GO:0047777)
0.0 0.5 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.5 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.2 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 0.3 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.4 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.3 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.3 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.3 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0 0.1 GO:0004061 arylformamidase activity(GO:0004061)
0.0 0.1 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.0 0.4 GO:0016289 CoA hydrolase activity(GO:0016289)
0.0 0.3 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.0 0.5 GO:0015301 anion:anion antiporter activity(GO:0015301)
0.0 0.4 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.2 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.0 0.4 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.1 GO:0060182 apelin receptor activity(GO:0060182)
0.0 0.3 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.2 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.1 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.0 0.4 GO:0051537 ferrous iron binding(GO:0008198) 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 4.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.1 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.3 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 3.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.2 GO:0070411 I-SMAD binding(GO:0070411)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.3 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.4 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.1 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.8 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.5 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.5 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.6 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.4 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.2 PID IFNG PATHWAY IFN-gamma pathway
0.0 0.2 PID ARF 3PATHWAY Arf1 pathway
0.0 0.2 PID GLYPICAN 1PATHWAY Glypican 1 network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 0.6 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 1.1 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.5 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.6 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.6 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.3 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.4 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.2 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.2 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.3 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.2 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.3 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.3 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.6 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.1 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.2 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.3 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.8 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.3 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.3 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.1 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade