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PRJNA207719: Tissue specific transcriptome profiling
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Results for hmx4
Z-value: 1.64
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Transcription factors associated with hmx4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| hmx4 | dr11_v1_chr1_-_40911332_40911332 | 0.54 | 3.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_233143 Show fit | 2.44 |
ENSDART00000175273
|
synaptic Ras GTPase activating protein 1a |
|
| chr1_-_14234076 Show fit | 1.55 |
ENSDART00000040049
|
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2 |
|
| chr1_-_14233815 Show fit | 1.34 |
ENSDART00000044896
|
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2 |
|
| chr16_-_26074529 Show fit | 1.22 |
ENSDART00000148653
ENSDART00000148923 |
transmembrane protein 145 |
|
| chr8_+_7144066 Show fit | 1.21 |
ENSDART00000146306
|
solute carrier family 6 (neurotransmitter transporter), member 6a |
|
| chr2_-_49978227 Show fit | 1.14 |
ENSDART00000142835
|
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1b |
|
| chr9_-_44642108 Show fit | 1.13 |
ENSDART00000086202
|
phosphodiesterase 1A, calmodulin-dependent |
|
| chr18_-_46763170 Show fit | 1.10 |
ENSDART00000171880
|
delta/notch-like EGF repeat containing |
|
| chr15_+_19544052 Show fit | 1.09 |
ENSDART00000062560
|
zgc:77784 |
|
| chr1_+_8662530 Show fit | 1.09 |
ENSDART00000054989
|
fascin actin-bundling protein 1b |
Network of associatons between targets according to the STRING database.
First level regulatory network of hmx4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | GO:0048024 | regulation of mRNA splicing, via spliceosome(GO:0048024) |
| 0.0 | 1.4 | GO:0051017 | actin filament bundle assembly(GO:0051017) |
| 0.0 | 1.2 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.0 | 1.2 | GO:0072348 | sulfur compound transport(GO:0072348) |
| 0.4 | 1.1 | GO:0014014 | negative regulation of gliogenesis(GO:0014014) |
| 0.3 | 1.1 | GO:0021730 | trigeminal sensory nucleus development(GO:0021730) |
| 0.2 | 1.1 | GO:0090134 | mesendoderm migration(GO:0090133) cell migration involved in mesendoderm migration(GO:0090134) |
| 0.1 | 1.1 | GO:2000650 | negative regulation of sodium ion transmembrane transporter activity(GO:2000650) |
| 0.0 | 1.1 | GO:0051209 | release of sequestered calcium ion into cytosol(GO:0051209) |
| 0.0 | 1.1 | GO:0001578 | microtubule bundle formation(GO:0001578) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | GO:0043679 | axon terminus(GO:0043679) |
| 0.0 | 1.8 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.2 | 1.1 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.0 | 1.1 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 0.9 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.3 | 0.8 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.1 | 0.8 | GO:0033181 | plasma membrane proton-transporting V-type ATPase complex(GO:0033181) |
| 0.0 | 0.8 | GO:0099634 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.2 | 0.7 | GO:1990909 | Wnt signalosome(GO:1990909) |
| 0.0 | 0.7 | GO:0071564 | npBAF complex(GO:0071564) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 3.4 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.1 | 2.9 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.0 | 1.2 | GO:0005343 | organic acid:sodium symporter activity(GO:0005343) |
| 0.4 | 1.1 | GO:0031704 | apelin receptor binding(GO:0031704) |
| 0.2 | 1.1 | GO:0005219 | ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763) |
| 0.1 | 1.1 | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
| 0.1 | 1.1 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.1 | 1.0 | GO:0031628 | opioid receptor binding(GO:0031628) |
| 0.0 | 1.0 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 0.9 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 0.8 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 0.6 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 0.5 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 0.5 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.4 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.4 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 0.4 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.3 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 1.1 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 0.8 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 0.6 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 0.6 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 0.6 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.6 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 0.5 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.0 | 0.4 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.4 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |