ISMARA results: hey2

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PRJNA207719: Tissue specific transcriptome profiling

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Results for hey2_hey1+heyl

Z-value: 1.34

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Transcription factors associated with hey2_hey1+heyl

Gene Symbol	Gene ID	Gene Info
hey2 NCBI UniProt	ENSDARG00000013441	hes-related family bHLH transcription factor with YRPW motif 2
heyl NCBI UniProt	ENSDARG00000055798	hes related family bHLH transcription factor with YRPW motif like
hey1 NCBI UniProt	ENSDARG00000070538	hes-related family bHLH transcription factor with YRPW motif 1
heyl NCBI UniProt	ENSDARG00000112770	hes related family bHLH transcription factor with YRPW motif like

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
heyl	dr11_v1_chr19_+_32553874_32553874	-0.31	6.1e-01	Click!
hey1	dr11_v1_chr19_-_31802296_31802296	0.23	7.1e-01	Click!
hey2	dr11_v1_chr20_-_39596338_39596338	-0.16	7.9e-01	Click!

Activity profile of hey2_hey1+heyl motif

Sorted Z-values of hey2_hey1+heyl motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr21_+_6780340 Show fit	1.15	ENSDART00000139493 ENSDART00000140478	olfm1b NCBI UniProt Show fit	olfactomedin 1b
chr6_-_60147517 Show fit	1.11	ENSDART00000083453	slc32a1 NCBI UniProt Show fit	solute carrier family 32 (GABA vesicular transporter), member 1
chr20_+_34915945 Show fit	1.01	ENSDART00000153064	snap25a NCBI UniProt Show fit	synaptosomal-associated protein, 25a
chr14_+_35748385 Show fit	0.87	ENSDART00000064617 ENSDART00000074671 ENSDART00000172803	gria2b NCBI UniProt Show fit	glutamate receptor, ionotropic, AMPA 2b
chr14_+_35748206 Show fit	0.86	ENSDART00000177391	gria2b NCBI UniProt Show fit	glutamate receptor, ionotropic, AMPA 2b
chr10_-_7913591 Show fit	0.78	ENSDART00000139661	slc35e4 NCBI UniProt Show fit	solute carrier family 35, member E4
chr20_+_23440632 Show fit	0.73	ENSDART00000180685 ENSDART00000042820	si:dkey-90m5.4 NCBI UniProt Show fit	si:dkey-90m5.4
chr25_+_3328487 Show fit	0.71	ENSDART00000181143	ldhbb NCBI UniProt Show fit	lactate dehydrogenase Bb
chr3_+_23488652 Show fit	0.70	ENSDART00000126282	nr1d1 NCBI UniProt Show fit	nuclear receptor subfamily 1, group d, member 1
chr8_+_21146262 Show fit	0.68	ENSDART00000045684	porcn NCBI UniProt Show fit	porcupine O-acyltransferase

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of hey2_hey1+heyl

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.1	GO:0098700	neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0	1.1	GO:0014059	dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.1	1.0	GO:0009749	response to carbohydrate(GO:0009743) response to hexose(GO:0009746) response to glucose(GO:0009749) response to monosaccharide(GO:0034284)
0.0	1.0	GO:0006383	transcription from RNA polymerase III promoter(GO:0006383)
0.0	1.0	GO:0016082	synaptic vesicle priming(GO:0016082)
0.0	0.9	GO:0007216	G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.2	0.7	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.1	0.7	GO:0060416	growth hormone receptor signaling pathway(GO:0060396) response to growth hormone(GO:0060416) cellular response to growth hormone stimulus(GO:0071378)
0.1	0.7	GO:0060561	apoptotic process involved in morphogenesis(GO:0060561)
0.0	0.7	GO:0016558	protein import into peroxisome matrix(GO:0016558)

Showing 1 to 10 of 90 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.7	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.1	1.2	GO:0098563	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2	1.0	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0	0.9	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.0	0.8	GO:0005666	DNA-directed RNA polymerase III complex(GO:0005666)
0.0	0.8	GO:0031225	anchored component of membrane(GO:0031225)
0.2	0.7	GO:0070195	growth hormone receptor complex(GO:0070195)
0.1	0.7	GO:0016586	RSC complex(GO:0016586)
0.0	0.6	GO:0031903	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1	0.5	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)

Showing 1 to 10 of 36 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.7	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
0.1	1.1	GO:0015295	solute:proton symporter activity(GO:0015295)
0.0	1.1	GO:0001786	phosphatidylserine binding(GO:0001786)
0.3	1.0	GO:0004373	glycogen (starch) synthase activity(GO:0004373)
0.1	1.0	GO:0003835	beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0	1.0	GO:0017075	syntaxin-1 binding(GO:0017075)
0.2	0.7	GO:0004903	growth hormone receptor activity(GO:0004903)
0.1	0.6	GO:0015189	L-lysine transmembrane transporter activity(GO:0015189)
0.1	0.6	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	0.6	GO:0042577	lipid phosphatase activity(GO:0042577)

Showing 1 to 10 of 69 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.1	0.5	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	0.2	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin

Showing 1 to 3 of 3 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.4	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.1	1.1	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.0	1.0	REACTOME GLUCOSE METABOLISM	Genes involved in Glucose metabolism
0.0	0.7	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.1	0.5	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.5	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.0	0.5	REACTOME RNA POL I TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase I Transcription Termination
0.0	0.5	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	0.4	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	0.3	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)

Showing 1 to 10 of 15 entries

Results for hey2_hey1+heyl

Z-value: 1.34

Motif logo

Transcription factors associated with hey2_hey1+heyl

Activity-expression correlation:

Activity profile of hey2_hey1+heyl motif

Sorted Z-values of hey2_hey1+heyl motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of hey2_hey1+heyl

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: