ISMARA results: glis3

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PRJNA207719: Tissue specific transcriptome profiling

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Results for glis3

Z-value: 0.52

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Transcription factors associated with glis3

Gene Symbol	Gene ID	Gene Info
glis3 NCBI UniProt	ENSDARG00000069726	GLIS family zinc finger 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
glis3	dr11_v1_chr10_-_690072_690170	0.71	1.8e-01	Click!

Activity profile of glis3 motif

Sorted Z-values of glis3 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr25_+_7461624 Show fit	1.13	ENSDART00000170569	syt12 NCBI UniProt Show fit	synaptotagmin XII
chr8_-_33114202 Show fit	0.65	ENSDART00000098840	ralgps1 NCBI UniProt Show fit	Ral GEF with PH domain and SH3 binding motif 1
chr13_-_638485 Show fit	0.56	ENSDART00000066080 ENSDART00000128969	slit1a NCBI UniProt Show fit	slit homolog 1a (Drosophila)
chr20_-_18915376 Show fit	0.44	ENSDART00000063725	xkr6b NCBI UniProt Show fit	XK, Kell blood group complex subunit-related family, member 6b
chr14_-_34044369 Show fit	0.41	ENSDART00000149396 ENSDART00000123607 ENSDART00000190746	cyfip2 NCBI UniProt Show fit	cytoplasmic FMR1 interacting protein 2
chr2_+_49246099 Show fit	0.40	ENSDART00000179089	sema6ba NCBI UniProt Show fit	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba
chr3_+_30190419 Show fit	0.25	ENSDART00000157320	akt1s1 NCBI UniProt Show fit	AKT1 substrate 1 (proline-rich)
chr20_-_26588736 Show fit	0.22	ENSDART00000134337	exoc2 NCBI UniProt Show fit	exocyst complex component 2
chr21_+_20950161 Show fit	0.18	ENSDART00000079698	htr1ab NCBI UniProt Show fit	5-hydroxytryptamine (serotonin) receptor 1A b
chr21_+_20949976 Show fit	0.17	ENSDART00000135342	htr1ab NCBI UniProt Show fit	5-hydroxytryptamine (serotonin) receptor 1A b

Showing 1 to 10 of 21 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of glis3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Total log-likelihood	Term	Description
1.1	GO:0060291	long-term synaptic potentiation(GO:0060291)
0.6	GO:0045773	positive regulation of axon extension(GO:0045773)
0.4	GO:0070782	phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.4	GO:0001964	startle response(GO:0001964)
0.4	GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.2	GO:0048011	neurotrophin TRK receptor signaling pathway(GO:0048011)
0.1	GO:0098700	neurotransmitter loading into synaptic vesicle(GO:0098700)

Showing 1 to 7 of 7 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	GO:0031209	SCAR complex(GO:0031209)
0.0	0.2	GO:0005922	connexon complex(GO:0005922)

Showing 1 to 2 of 2 entries

Gene overrepresentation in molecular function category:

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Total log-likelihood	Term	Description
0.9	GO:0001786	phosphatidylserine binding(GO:0001786)
0.6	GO:0048495	Roundabout binding(GO:0048495)
0.4	GO:0000340	RNA 7-methylguanosine cap binding(GO:0000340)
0.4	GO:0043176	amine binding(GO:0043176) serotonin binding(GO:0051378)
0.2	GO:0055077	gap junction hemi-channel activity(GO:0055077)
0.1	GO:0005326	neurotransmitter transporter activity(GO:0005326)

Showing 1 to 6 of 6 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	0.2	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Showing 1 to 2 of 2 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
0.2	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.2	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.2	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing

Showing 1 to 3 of 3 entries

Results for glis3

Z-value: 0.52

Motif logo

Transcription factors associated with glis3

Activity-expression correlation:

Activity profile of glis3 motif

Sorted Z-values of glis3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of glis3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: