ISMARA results: glis2a+glis2b

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PRJNA207719: Tissue specific transcriptome profiling

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Results for glis2a+glis2b

Z-value: 0.75

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Transcription factors associated with glis2a+glis2b

Gene Symbol	Gene ID	Gene Info
glis2a NCBI UniProt	ENSDARG00000078388	GLIS family zinc finger 2a
glis2b NCBI UniProt	ENSDARG00000100232	GLIS family zinc finger 2b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
glis2a	dr11_v1_chr22_-_26558166_26558166	0.64	2.5e-01	Click!
glis2b	dr11_v1_chr3_+_12322170_12322170	0.58	3.0e-01	Click!

Activity profile of glis2a+glis2b motif

Sorted Z-values of glis2a+glis2b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_+_18364176 Show fit	0.65	ENSDART00000171606 ENSDART00000186368	cd248a NCBI UniProt Show fit	CD248 molecule, endosialin a
chr23_-_45705525 Show fit	0.53	ENSDART00000148959	ednrab NCBI UniProt Show fit	endothelin receptor type Ab
chr20_+_25340814 Show fit	0.53	ENSDART00000063028	ctgfa NCBI UniProt Show fit	connective tissue growth factor a
chr15_-_97205 Show fit	0.51	ENSDART00000158734	BACE1 NCBI UniProt Show fit	beta-secretase 1
chr10_+_33982010 Show fit	0.47	ENSDART00000180431	fryb NCBI UniProt Show fit	furry homolog b (Drosophila)
chr24_+_25471196 Show fit	0.46	ENSDART00000066625	smpx NCBI UniProt Show fit	small muscle protein, X-linked
chr13_-_638485 Show fit	0.40	ENSDART00000066080 ENSDART00000128969	slit1a NCBI UniProt Show fit	slit homolog 1a (Drosophila)
chr12_-_4070058 Show fit	0.40	ENSDART00000042200	aldoab NCBI UniProt Show fit	aldolase a, fructose-bisphosphate, b
chr17_-_20717845 Show fit	0.39	ENSDART00000150037	ank3b NCBI UniProt Show fit	ankyrin 3b
chr23_+_42810055 Show fit	0.39	ENSDART00000186647	myl9a NCBI UniProt Show fit	myosin, light chain 9a, regulatory

Showing 1 to 10 of 65 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of glis2a+glis2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0003319	cardioblast migration to the midline involved in heart rudiment formation(GO:0003319)
0.0	0.4	GO:0045773	positive regulation of axon extension(GO:0045773)
0.0	0.4	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1	0.2	GO:0003100	regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.1	0.2	GO:2000659	regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0	0.1	GO:0071498	vitamin K metabolic process(GO:0042373) cellular response to fluid shear stress(GO:0071498)
0.0	0.1	GO:0051095	regulation of helicase activity(GO:0051095) positive regulation of helicase activity(GO:0051096)
0.0	0.1	GO:0034058	endosomal vesicle fusion(GO:0034058)
0.0	0.1	GO:0031174	lifelong otolith mineralization(GO:0031174)
0.0	0.1	GO:0035372	protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)

Showing 1 to 10 of 10 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0043034	costamere(GO:0043034)
0.0	0.2	GO:0000931	gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0	0.1	GO:0030897	HOPS complex(GO:0030897)

Showing 1 to 3 of 3 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:1990430	extracellular matrix protein binding(GO:1990430)
0.1	0.5	GO:0004962	endothelin receptor activity(GO:0004962)
0.0	0.4	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.4	GO:0048495	Roundabout binding(GO:0048495)
0.1	0.2	GO:0031708	endothelin B receptor binding(GO:0031708)
0.0	0.2	GO:0061578	Lys63-specific deubiquitinase activity(GO:0061578)
0.0	0.2	GO:0043015	gamma-tubulin binding(GO:0043015)
0.0	0.1	GO:0004517	nitric-oxide synthase activity(GO:0004517)
0.0	0.1	GO:0051717	inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity(GO:0051717) phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)

Showing 1 to 10 of 11 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.2	PID ALK2 PATHWAY	ALK2 signaling events

Showing 1 to 1 of 1 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.2	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	0.1	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling

Showing 1 to 2 of 2 entries

Results for glis2a+glis2b

Z-value: 0.75

Motif logo

Transcription factors associated with glis2a+glis2b

Activity-expression correlation:

Activity profile of glis2a+glis2b motif

Sorted Z-values of glis2a+glis2b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of glis2a+glis2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: