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PRJNA207719: Tissue specific transcriptome profiling
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Results for gli1+gli2b
Z-value: 1.26
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Transcription factors associated with gli1+gli2b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| gli1 | dr11_v1_chr6_-_59505589_59505589 | -0.37 | 5.5e-01 | Click! |
| gli2b | dr11_v1_chr11_+_43661735_43661735 | -0.28 | 6.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr23_+_20422661 Show fit | 1.27 |
ENSDART00000144047
ENSDART00000104336 |
troponin C type 2 (fast) |
|
| chr7_+_29952719 Show fit | 1.06 |
ENSDART00000173737
|
alpha-tropomyosin |
|
| chr7_+_29952169 Show fit | 1.05 |
ENSDART00000173540
ENSDART00000173940 ENSDART00000173906 ENSDART00000173772 ENSDART00000173506 ENSDART00000039657 |
alpha-tropomyosin |
|
| chr12_-_464007 Show fit | 1.01 |
ENSDART00000106669
|
dehydrogenase/reductase (SDR family) member 7Cb |
|
| chr18_+_5547185 Show fit | 1.00 |
ENSDART00000193977
|
nicotinamide nucleotide transhydrogenase 2 |
|
| chr7_+_29951997 Show fit | 0.99 |
ENSDART00000173453
|
alpha-tropomyosin |
|
| chr14_+_15543331 Show fit | 0.73 |
ENSDART00000167025
|
si:dkey-203a12.7 |
|
| chr10_+_33171501 Show fit | 0.72 |
ENSDART00000159666
|
myosin, light chain 10, regulatory |
|
| chr14_+_15257658 Show fit | 0.70 |
ENSDART00000161625
ENSDART00000193577 |
si:dkey-77g12.4 si:dkey-203a12.5 |
|
| chr14_+_15430991 Show fit | 0.61 |
ENSDART00000158221
|
si:dkey-203a12.5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of gli1+gli2b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | GO:0061515 | myeloid cell development(GO:0061515) |
| 0.1 | 1.3 | GO:0014823 | response to activity(GO:0014823) |
| 0.3 | 1.0 | GO:0006740 | NADPH regeneration(GO:0006740) |
| 0.0 | 0.5 | GO:0061056 | sclerotome development(GO:0061056) |
| 0.0 | 0.5 | GO:0009134 | nucleoside diphosphate catabolic process(GO:0009134) |
| 0.1 | 0.4 | GO:1903428 | regulation of nitric oxide biosynthetic process(GO:0045428) positive regulation of nitric oxide biosynthetic process(GO:0045429) positive regulation of reactive oxygen species biosynthetic process(GO:1903428) positive regulation of nitric oxide metabolic process(GO:1904407) |
| 0.1 | 0.3 | GO:1903587 | regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587) positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903589) |
| 0.1 | 0.3 | GO:0032218 | riboflavin transport(GO:0032218) |
| 0.1 | 0.3 | GO:0003210 | cardiac atrium formation(GO:0003210) |
| 0.0 | 0.3 | GO:0015810 | acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 1.3 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 0.6 | GO:0045277 | respiratory chain complex IV(GO:0045277) |
| 0.0 | 0.4 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 0.3 | GO:0001405 | presequence translocase-associated import motor(GO:0001405) |
| 0.0 | 0.2 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
| 0.0 | 0.1 | GO:0005749 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | GO:0042803 | protein homodimerization activity(GO:0042803) |
| 0.0 | 1.3 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.3 | 1.0 | GO:0016652 | NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652) |
| 0.0 | 0.6 | GO:0016675 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.5 | GO:0004382 | guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134) |
| 0.1 | 0.3 | GO:0032217 | riboflavin transporter activity(GO:0032217) |
| 0.1 | 0.3 | GO:0060182 | apelin receptor activity(GO:0060182) |
| 0.0 | 0.3 | GO:0004960 | thromboxane receptor activity(GO:0004960) |
| 0.0 | 0.3 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.9 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 0.3 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |
| 0.0 | 0.3 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.2 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |