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PRJNA207719: Tissue specific transcriptome profiling
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Results for gfi1b
Z-value: 1.52
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Transcription factors associated with gfi1b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| gfi1b | dr11_v1_chr21_-_17290941_17290941 | -0.50 | 3.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr25_+_19999623 Show fit | 2.28 |
ENSDART00000026401
|
zgc:194665 |
|
| chr20_+_50852356 Show fit | 2.25 |
ENSDART00000167517
ENSDART00000168396 |
gephyrin b |
|
| chr17_-_12389259 Show fit | 2.02 |
ENSDART00000185724
|
synaptosomal-associated protein, 25b |
|
| chr23_-_35694461 Show fit | 1.84 |
ENSDART00000185884
|
tubulin, alpha 1c |
|
| chr23_-_35694171 Show fit | 1.81 |
ENSDART00000077539
|
tubulin, alpha 1c |
|
| chr17_-_12385308 Show fit | 1.71 |
ENSDART00000080927
|
synaptosomal-associated protein, 25b |
|
| chr17_+_15433518 Show fit | 1.62 |
ENSDART00000026180
|
fatty acid binding protein 7, brain, a |
|
| chr17_+_15433671 Show fit | 1.60 |
ENSDART00000149568
|
fatty acid binding protein 7, brain, a |
|
| chr1_+_12763461 Show fit | 1.46 |
ENSDART00000159226
ENSDART00000180121 |
protocadherin 10a |
|
| chr21_+_9628854 Show fit | 1.39 |
ENSDART00000161753
ENSDART00000160711 |
mitogen-activated protein kinase 10 |
Network of associatons between targets according to the STRING database.
First level regulatory network of gfi1b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.7 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.8 | 2.3 | GO:0018315 | establishment of synaptic specificity at neuromuscular junction(GO:0007529) molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579) |
| 0.2 | 2.0 | GO:0044805 | late nucleophagy(GO:0044805) |
| 0.6 | 1.7 | GO:0048917 | posterior lateral line ganglion development(GO:0048917) |
| 0.1 | 1.5 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
| 0.1 | 1.5 | GO:0097324 | melanocyte migration(GO:0097324) |
| 0.0 | 1.4 | GO:1903052 | positive regulation of proteolysis involved in cellular protein catabolic process(GO:1903052) |
| 0.0 | 1.4 | GO:0048484 | enteric nervous system development(GO:0048484) |
| 0.1 | 1.3 | GO:0043217 | myelin maintenance(GO:0043217) |
| 0.0 | 1.3 | GO:0070831 | basement membrane assembly(GO:0070831) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.7 | GO:0005874 | microtubule(GO:0005874) |
| 0.6 | 3.7 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.0 | 2.3 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.1 | 2.0 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.0 | 2.0 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.3 | 1.4 | GO:0043291 | RAVE complex(GO:0043291) |
| 0.1 | 1.2 | GO:0043256 | basal lamina(GO:0005605) laminin complex(GO:0043256) |
| 0.0 | 1.1 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 0.9 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 0.9 | GO:0034707 | chloride channel complex(GO:0034707) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.5 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 3.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.2 | 3.2 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.8 | 2.3 | GO:0061598 | molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599) |
| 0.0 | 2.0 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 1.7 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.1 | 1.4 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.0 | 1.4 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 1.3 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.1 | 1.0 | GO:0001733 | galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 1.0 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.0 | 0.8 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 0.4 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 0.4 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.3 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.2 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.1 | PID IGF1 PATHWAY | IGF1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.0 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 1.7 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 1.4 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 1.1 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.0 | 0.6 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.0 | 0.6 | REACTOME G ALPHA1213 SIGNALLING EVENTS | Genes involved in G alpha (12/13) signalling events |
| 0.0 | 0.3 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 0.3 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.2 | REACTOME ACYL CHAIN REMODELLING OF PG | Genes involved in Acyl chain remodelling of PG |
| 0.0 | 0.2 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |