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PRJNA207719: Tissue specific transcriptome profiling
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Results for gfi1aa+gfi1ab
Z-value: 2.56
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Transcription factors associated with gfi1aa+gfi1ab
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000020746 | growth factor independent 1A transcription repressor a | |
| ENSDARG00000044457 | growth factor independent 1A transcription repressor b | |
| ENSDARG00000114140 | growth factor independent 1A transcription repressor b |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| gfi1ab | dr11_v1_chr6_-_29007493_29007493 | -0.55 | 3.3e-01 | Click! |
| gfi1aa | dr11_v1_chr2_+_10771787_10771787 | 0.50 | 3.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_+_35806605 Show fit | 3.00 |
ENSDART00000173093
|
glutamate receptor, ionotropic, AMPA 2b |
|
| chr9_-_18877597 Show fit | 2.80 |
ENSDART00000099446
|
potassium channel tetramerization domain containing 4 |
|
| chr17_+_15433518 Show fit | 2.32 |
ENSDART00000026180
|
fatty acid binding protein 7, brain, a |
|
| chr17_+_15433671 Show fit | 2.30 |
ENSDART00000149568
|
fatty acid binding protein 7, brain, a |
|
| chr5_+_64732270 Show fit | 2.14 |
ENSDART00000134241
|
olfactomedin 1a |
|
| chr18_-_1185772 Show fit | 2.02 |
ENSDART00000143245
|
neuroplastin b |
|
| chr24_+_39137001 Show fit | 1.96 |
ENSDART00000181086
ENSDART00000183724 ENSDART00000193466 |
TBC1 domain family, member 24 |
|
| chr18_+_22793465 Show fit | 1.95 |
ENSDART00000149685
|
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a |
|
| chr7_-_22132265 Show fit | 1.83 |
ENSDART00000125284
ENSDART00000112978 |
neuroligin 2a |
|
| chr21_+_26697536 Show fit | 1.71 |
ENSDART00000004109
|
guanine nucleotide binding protein (G protein), gamma 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of gfi1aa+gfi1ab
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.3 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.2 | 4.0 | GO:0048936 | peripheral nervous system neuron axonogenesis(GO:0048936) |
| 0.1 | 3.9 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 0.4 | 3.6 | GO:1902868 | positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) |
| 0.1 | 3.3 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 0.0 | 2.9 | GO:0051260 | protein homooligomerization(GO:0051260) |
| 0.2 | 2.5 | GO:0006208 | pyrimidine nucleobase catabolic process(GO:0006208) |
| 0.1 | 2.4 | GO:0048854 | brain morphogenesis(GO:0048854) |
| 0.0 | 2.3 | GO:0070588 | calcium ion transmembrane transport(GO:0070588) |
| 0.0 | 2.2 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.1 | GO:0030424 | axon(GO:0030424) |
| 0.2 | 5.1 | GO:0048788 | cytoskeleton of presynaptic active zone(GO:0048788) |
| 0.0 | 5.0 | GO:0043005 | neuron projection(GO:0043005) |
| 0.0 | 5.0 | GO:0045202 | synapse(GO:0045202) |
| 0.0 | 4.9 | GO:0030425 | dendrite(GO:0030425) |
| 0.1 | 4.7 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 4.3 | GO:0099634 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.1 | 4.2 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 3.4 | GO:0005911 | cell-cell junction(GO:0005911) |
| 0.1 | 2.4 | GO:0031680 | G-protein beta/gamma-subunit complex(GO:0031680) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.6 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.3 | 3.8 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.1 | 3.5 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 3.4 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.5 | 2.6 | GO:0051430 | mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.2 | 2.5 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
| 0.1 | 2.4 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.1 | 2.3 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.1 | 2.2 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.3 | 2.1 | GO:0099530 | G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.0 | 1.3 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 1.1 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 1.0 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 0.9 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 0.8 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.0 | 0.8 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.7 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 0.7 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.0 | 0.6 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.4 | REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | Genes involved in Thromboxane signalling through TP receptor |
| 0.0 | 1.5 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.2 | 1.4 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 1.4 | REACTOME CIRCADIAN CLOCK | Genes involved in Circadian Clock |
| 0.1 | 1.3 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.1 | 1.2 | REACTOME G PROTEIN ACTIVATION | Genes involved in G-protein activation |
| 0.1 | 1.2 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 1.0 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.0 | 1.0 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 0.9 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |