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PRJNA207719: Tissue specific transcriptome profiling
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Results for gcm2
Z-value: 1.14
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Transcription factors associated with gcm2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| gcm2 | dr11_v1_chr24_-_8831866_8831912 | -0.42 | 4.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr24_-_6158933 Show fit | 1.51 |
ENSDART00000021609
|
glutamate decarboxylase 2 |
|
| chr10_+_7182168 Show fit | 1.28 |
ENSDART00000172766
|
pleckstrin and Sec7 domain containing 3, like |
|
| chr16_+_45571956 Show fit | 1.13 |
ENSDART00000143867
|
synaptic Ras GTPase activating protein 1b |
|
| chr5_-_23317477 Show fit | 1.09 |
ENSDART00000090171
|
neuroligin 3b |
|
| chr10_+_7182423 Show fit | 1.04 |
ENSDART00000186788
|
pleckstrin and Sec7 domain containing 3, like |
|
| chr3_-_30061985 Show fit | 1.01 |
ENSDART00000189583
|
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 |
|
| chr2_-_42871286 Show fit | 1.01 |
ENSDART00000087823
|
adenylate cyclase 8 (brain) |
|
| chr18_-_21218851 Show fit | 0.92 |
ENSDART00000060160
|
calbindin 2a |
|
| chr19_-_8604429 Show fit | 0.90 |
ENSDART00000151165
|
tripartite motif containing 46b |
|
| chr1_-_20911297 Show fit | 0.89 |
ENSDART00000078271
|
carboxypeptidase E |
Network of associatons between targets according to the STRING database.
First level regulatory network of gcm2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.8 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 2.0 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.0 | 1.6 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.5 | 1.5 | GO:0009449 | gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 0.1 | 1.1 | GO:0097104 | presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105) |
| 0.0 | 1.1 | GO:0036269 | swimming behavior(GO:0036269) |
| 0.1 | 1.0 | GO:0016199 | axon midline choice point recognition(GO:0016199) |
| 0.2 | 0.9 | GO:0099509 | regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271) |
| 0.0 | 0.9 | GO:0006493 | protein O-linked glycosylation(GO:0006493) |
| 0.0 | 0.9 | GO:1902668 | negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.3 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 1.8 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 1.6 | GO:1902710 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
| 0.0 | 0.9 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 0.8 | GO:0098839 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.1 | 0.6 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.0 | 0.6 | GO:0034706 | voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706) |
| 0.0 | 0.5 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 0.4 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.0 | 0.4 | GO:0071565 | nBAF complex(GO:0071565) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.5 | 1.5 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.0 | 1.5 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.0 | 1.3 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 1.1 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 1.0 | GO:0004016 | adenylate cyclase activity(GO:0004016) |
| 0.1 | 0.9 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) protein O-GlcNAc transferase activity(GO:0097363) |
| 0.1 | 0.8 | GO:0099530 | G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530) |
| 0.1 | 0.8 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.0 | 0.8 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 0.9 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 0.7 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 0.4 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 0.2 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.5 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 1.0 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.0 | 0.9 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 0.9 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.5 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 0.4 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.0 | 0.4 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.2 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |