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PRJNA207719: Tissue specific transcriptome profiling

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Results for gbx2

Z-value: 0.49

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Transcription factors associated with gbx2

Gene Symbol Gene ID Gene Info
gbx2
ENSDARG00000002933 gastrulation brain homeobox 2
gbx2
ENSDARG00000116377 gastrulation brain homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
gbx2dr11_v1_chr6_+_16031189_160311890.692.0e-01Click!

Activity profile of gbx2 motif

Sorted Z-values of gbx2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_21037840 0.26 ENSDART00000002393
rundc3aa
RUN domain containing 3Aa
chr18_+_26895994 0.25 ENSDART00000098347
ch25hl1.2
cholesterol 25-hydroxylase like 1, tandem duplicate 2
chr8_+_31821396 0.22 ENSDART00000077053
plcxd3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr11_+_24620742 0.22 ENSDART00000182471
ENSDART00000048365
syt6b
synaptotagmin VIb
chr12_-_35386910 0.22 ENSDART00000153453
camk2g1
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1
chr10_-_34741738 0.21 ENSDART00000163072
dclk1a
doublecortin-like kinase 1a
chr18_+_17537344 0.20 ENSDART00000025782
nup93
nucleoporin 93
chr17_+_51499789 0.19 ENSDART00000187701
CABZ01067581.1

chr5_+_30624183 0.18 ENSDART00000141444
abcg4a
ATP-binding cassette, sub-family G (WHITE), member 4a
chr4_-_5019113 0.18 ENSDART00000189321
ENSDART00000081990
strip2
striatin interacting protein 2
chr17_-_37214196 0.18 ENSDART00000128715
kif3cb
kinesin family member 3Cb
chr8_+_20140321 0.18 ENSDART00000012120
acsbg2
acyl-CoA synthetase bubblegum family member 2
chr2_-_36918709 0.17 ENSDART00000084876
zgc:153654
zgc:153654
chr22_+_24157807 0.17 ENSDART00000159165
b3galt2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr17_+_24318753 0.16 ENSDART00000064083
otx1
orthodenticle homeobox 1
chr15_-_10341048 0.16 ENSDART00000171013
tenm4
teneurin transmembrane protein 4
chr1_+_18811679 0.16 ENSDART00000078610
slc25a51a
solute carrier family 25, member 51a
chr21_-_43606502 0.16 ENSDART00000151030
si:ch73-362m14.4
si:ch73-362m14.4
chr17_+_10593398 0.15 ENSDART00000168897
ENSDART00000193989
ENSDART00000191664
ENSDART00000167188
mapkbp1
mitogen-activated protein kinase binding protein 1
chr15_-_11956981 0.15 ENSDART00000164163
si:dkey-202l22.3
si:dkey-202l22.3
chr5_+_57773222 0.14 ENSDART00000135344
ppp2r1ba
protein phosphatase 2, regulatory subunit A, beta a
chr23_-_333457 0.14 ENSDART00000114486
uhrf1bp1
UHRF1 binding protein 1
chr18_+_8833251 0.14 ENSDART00000143519
impdh1a
IMP (inosine 5'-monophosphate) dehydrogenase 1a
chr18_+_7639401 0.14 ENSDART00000092416
rabl2
RAB, member of RAS oncogene family-like 2
chr23_+_4253957 0.13 ENSDART00000008761
arl6ip5b
ADP-ribosylation factor-like 6 interacting protein 5b
chr10_+_43797130 0.13 ENSDART00000027242
nr2f1b
nuclear receptor subfamily 2, group F, member 1b
chr7_-_33684632 0.13 ENSDART00000130553
tle3b
transducin-like enhancer of split 3b
chr4_-_5018705 0.13 ENSDART00000154025
strip2
striatin interacting protein 2
chr4_+_11384891 0.13 ENSDART00000092381
ENSDART00000186577
ENSDART00000191054
ENSDART00000191584
pcloa
piccolo presynaptic cytomatrix protein a
chr5_-_69923241 0.13 ENSDART00000187389
fktn
fukutin
chr24_-_25364775 0.13 ENSDART00000151915
ptchd1
patched domain containing 1
chr16_+_5678071 0.12 ENSDART00000011166
ENSDART00000134198
ENSDART00000131575
zgc:158689
zgc:158689
chr20_-_18382708 0.12 ENSDART00000170864
ENSDART00000166762
ENSDART00000191333
vipas39
VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
chr22_-_619711 0.12 ENSDART00000192778
srsf3b
serine/arginine-rich splicing factor 3b
chr11_-_422484 0.12 ENSDART00000122253
znf831
zinc finger protein 831
chr15_-_45110011 0.11 ENSDART00000182047
ENSDART00000188662
CABZ01072607.1

chr1_+_40023640 0.11 ENSDART00000101623
lgi2b
leucine-rich repeat LGI family, member 2b
chr8_+_18010568 0.11 ENSDART00000121984
ssbp3b
single stranded DNA binding protein 3b
chr8_+_23105117 0.11 ENSDART00000025171
ythdf1
YTH N(6)-methyladenosine RNA binding protein 1
chr2_+_35240485 0.10 ENSDART00000179804
tnr
tenascin R (restrictin, janusin)
chr1_-_18803919 0.10 ENSDART00000020970
pgm2
phosphoglucomutase 2
chr18_+_31057143 0.10 ENSDART00000164585
mvda
mevalonate (diphospho) decarboxylase a
chr1_-_8000428 0.10 ENSDART00000133098
si:dkey-79f11.5
si:dkey-79f11.5
chr13_+_733027 0.10 ENSDART00000149547
nrxn1b
neurexin 1b
chr1_-_22512063 0.10 ENSDART00000031546
ENSDART00000190987
chrna6
cholinergic receptor, nicotinic, alpha 6
chr2_-_23004286 0.10 ENSDART00000134664
ENSDART00000110373
ENSDART00000185833
ENSDART00000187235
znf414
mllt1b
zinc finger protein 414
MLLT1, super elongation complex subunit b
chr10_-_14929630 0.10 ENSDART00000121892
ENSDART00000044756
ENSDART00000128579
ENSDART00000147653
smad2
SMAD family member 2
chr14_-_14643190 0.09 ENSDART00000167119
znf185
zinc finger protein 185 with LIM domain
chr3_-_61336841 0.09 ENSDART00000155414
tecpr1b
tectonin beta-propeller repeat containing 1b
chr10_-_32920690 0.09 ENSDART00000136245
cux1a
cut-like homeobox 1a
chr18_-_15932704 0.08 ENSDART00000127769
plekhg7
pleckstrin homology domain containing, family G (with RhoGef domain) member 7
chr14_+_25816874 0.08 ENSDART00000005499
glra1
glycine receptor, alpha 1
chr16_-_7379328 0.08 ENSDART00000060447
med18
mediator of RNA polymerase II transcription, subunit 18 homolog (yeast)
chr12_+_5977777 0.08 ENSDART00000152302
si:ch211-131k2.2
si:ch211-131k2.2
chr9_-_9671244 0.08 ENSDART00000018228
gsk3b
glycogen synthase kinase 3 beta
chr3_+_28581397 0.08 ENSDART00000150893
sept12
septin 12
chr7_-_58098814 0.08 ENSDART00000147287
ENSDART00000043984
ank2b
ankyrin 2b, neuronal
chr8_+_23826985 0.07 ENSDART00000187430
mapk14a
mitogen-activated protein kinase 14a
chr23_+_42254960 0.07 ENSDART00000102980
zcchc11
zinc finger, CCHC domain containing 11
chr18_-_16937008 0.07 ENSDART00000100117
ENSDART00000022640
ENSDART00000136541
znf143b
zinc finger protein 143b
chr14_+_35464994 0.07 ENSDART00000115307
si:ch211-203d1.3
si:ch211-203d1.3
chr7_+_59677273 0.07 ENSDART00000039535
ENSDART00000132044
trmt44
tRNA methyltransferase 44 homolog
chr17_+_1496107 0.07 ENSDART00000187804
LO018430.1

chr11_-_2632747 0.07 ENSDART00000008133
si:ch211-160o17.2
si:ch211-160o17.2
chr11_-_12158412 0.07 ENSDART00000147670
npepps
aminopeptidase puromycin sensitive
chr19_-_20430892 0.07 ENSDART00000111409
tbc1d5
TBC1 domain family, member 5
chr18_+_16750080 0.07 ENSDART00000136320
rnf141
ring finger protein 141
chr20_+_18741089 0.06 ENSDART00000183218
fam167ab
family with sequence similarity 167, member Ab
chr3_-_26921475 0.06 ENSDART00000130281
ciita
class II, major histocompatibility complex, transactivator
chr8_+_21229718 0.05 ENSDART00000100222
cry1ba
cryptochrome circadian clock 1ba
chr15_-_16177603 0.05 ENSDART00000156352
si:ch211-259g3.4
si:ch211-259g3.4
chr20_-_7069612 0.05 ENSDART00000040793
sirt5
sirtuin 5
chr20_-_7128612 0.05 ENSDART00000146755
ENSDART00000036871
si:ch211-121a2.4
si:ch211-121a2.4
chr14_-_3180841 0.05 ENSDART00000184370
ENSDART00000183810
csf1ra
colony stimulating factor 1 receptor, a
chr24_+_35881124 0.05 ENSDART00000143015
klhl14
kelch-like family member 14
chr7_+_53755054 0.04 ENSDART00000181629
neo1a
neogenin 1a
chr11_+_6819050 0.04 ENSDART00000104289
rab3ab
RAB3A, member RAS oncogene family, b
chr22_-_36530902 0.04 ENSDART00000056188
polr2h
info polymerase (RNA) II (DNA directed) polypeptide H
chr13_-_33654931 0.04 ENSDART00000020350
snx5
sorting nexin 5
chr22_+_2417105 0.04 ENSDART00000106415
zgc:113220
zgc:113220
chr19_+_21820144 0.04 ENSDART00000181996
CU856623.1

chr16_-_36093776 0.04 ENSDART00000159134
OSCP1
organic solute carrier partner 1
chr9_+_55154414 0.03 ENSDART00000182924
ANOS1
anosmin 1
chr9_-_30555725 0.03 ENSDART00000079222
chaf1b
chromatin assembly factor 1, subunit B
chr9_+_711822 0.03 ENSDART00000136627
ybey
ybeY metallopeptidase
chr11_+_31323746 0.03 ENSDART00000180220
ENSDART00000189937
sipa1l2
signal-induced proliferation-associated 1 like 2
chr8_-_25729542 0.02 ENSDART00000078149
ENSDART00000085779
foxp3a
forkhead box P3a
chr1_+_54655160 0.02 ENSDART00000190319
si:ch211-202h22.7
si:ch211-202h22.7
chr24_-_33801668 0.02 ENSDART00000079202
abcb8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
chr6_-_42369186 0.02 ENSDART00000039868
usp4
ubiquitin specific peptidase 4 (proto-oncogene)
chr2_-_26720854 0.02 ENSDART00000148110
si:dkey-181m9.8
si:dkey-181m9.8
chr17_+_41302660 0.02 ENSDART00000059480
fosl2
fos-like antigen 2
chr22_+_980290 0.01 ENSDART00000065377
def6b
differentially expressed in FDCP 6b homolog (mouse)
chr20_-_49889111 0.01 ENSDART00000058858
kif13bb
kinesin family member 13Bb
chr5_+_27897504 0.01 ENSDART00000130936
adam28
ADAM metallopeptidase domain 28
chr5_-_20123002 0.01 ENSDART00000026516
pxmp2
peroxisomal membrane protein 2
chr19_-_27336092 0.01 ENSDART00000176885
gtf2h4
general transcription factor IIH, polypeptide 4
chr3_+_32118670 0.01 ENSDART00000055287
ENSDART00000111688
zgc:109934
zgc:109934
chr16_-_26296477 0.01 ENSDART00000157553
erfl1
Ets2 repressor factor like 1
chr6_-_39218609 0.01 ENSDART00000133305
os9
osteosarcoma amplified 9, endoplasmic reticulum lectin
chr21_-_22827548 0.01 ENSDART00000079161
angptl5
angiopoietin-like 5
chr11_+_2855430 0.01 ENSDART00000172837
kif21b
kinesin family member 21B
chr10_-_11761927 0.01 ENSDART00000138748
adamts6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr11_+_24340166 0.01 ENSDART00000188719
rbm39a
RNA binding motif protein 39a

Network of associatons between targets according to the STRING database.

First level regulatory network of gbx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752)
0.0 0.2 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.0 0.2 GO:0032289 central nervous system myelin formation(GO:0032289)
0.0 0.1 GO:0071361 cellular response to ethanol(GO:0071361)
0.0 0.4 GO:0055117 regulation of cardiac muscle contraction(GO:0055117)
0.0 0.1 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.0 0.1 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.0 0.1 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.0 0.1 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.1 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.0 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.0 0.1 GO:0046037 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.0 0.1 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.0 0.0 GO:0071675 regulation of macrophage chemotaxis(GO:0010758) positive regulation of macrophage chemotaxis(GO:0010759) regulation of odontogenesis(GO:0042481) mononuclear cell migration(GO:0071674) regulation of mononuclear cell migration(GO:0071675)
0.0 0.2 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.1 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.1 GO:0040016 embryonic cleavage(GO:0040016) positive regulation of myoblast fusion(GO:1901741)
0.0 0.2 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0098982 GABA-ergic synapse(GO:0098982)
0.0 0.1 GO:0070847 core mediator complex(GO:0070847)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
0.0 0.1 GO:0031835 neurokinin receptor binding(GO:0031834) substance P receptor binding(GO:0031835)
0.0 0.1 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.1 GO:0000035 acyl binding(GO:0000035)
0.0 0.2 GO:0016405 CoA-ligase activity(GO:0016405)
0.0 0.2 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.1 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors