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PRJNA207719: Tissue specific transcriptome profiling
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Results for gata3
Z-value: 2.99
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Transcription factors associated with gata3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| gata3 | dr11_v1_chr4_-_25064510_25064510 | 0.16 | 8.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_49159207 Show fit | 5.43 |
ENSDART00000041942
|
tetraspanin 2a |
|
| chr7_-_72067475 Show fit | 5.01 |
ENSDART00000017763
|
|
|
| chr7_+_13382852 Show fit | 4.99 |
ENSDART00000166318
|
diacylglycerol lipase, alpha |
|
| chr21_+_24287403 Show fit | 4.60 |
ENSDART00000111169
|
cell adhesion molecule 1a |
|
| chr22_+_635813 Show fit | 4.16 |
ENSDART00000179067
|
|
|
| chr12_+_5189776 Show fit | 3.67 |
ENSDART00000081298
|
leucine-rich, glioma inactivated 1b |
|
| chr21_-_43079161 Show fit | 3.47 |
ENSDART00000144151
|
janus kinase and microtubule interacting protein 2 |
|
| chr20_+_9828769 Show fit | 3.44 |
ENSDART00000160480
ENSDART00000053844 ENSDART00000080691 |
syntaxin binding protein 6 (amisyn), like |
|
| chr9_-_35557397 Show fit | 3.39 |
ENSDART00000100681
|
neural cell adhesion molecule 2 |
|
| chr19_+_12444943 Show fit | 3.27 |
ENSDART00000135706
|
low density lipoprotein receptor class A domain containing 4a |
Network of associatons between targets according to the STRING database.
First level regulatory network of gata3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 5.1 | GO:0098920 | endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921) |
| 0.1 | 4.1 | GO:0048843 | negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668) |
| 0.0 | 3.9 | GO:0021782 | glial cell development(GO:0021782) |
| 0.1 | 3.6 | GO:0048854 | brain morphogenesis(GO:0048854) |
| 0.1 | 3.5 | GO:0006893 | Golgi to plasma membrane transport(GO:0006893) |
| 0.0 | 3.4 | GO:0021549 | cerebellum development(GO:0021549) |
| 0.5 | 3.3 | GO:0060394 | negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394) |
| 0.0 | 3.1 | GO:0001666 | response to hypoxia(GO:0001666) |
| 0.0 | 3.0 | GO:0007018 | microtubule-based movement(GO:0007018) |
| 0.7 | 2.9 | GO:0006867 | asparagine transport(GO:0006867) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.6 | GO:0043005 | neuron projection(GO:0043005) |
| 0.0 | 11.2 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 5.4 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.2 | 3.7 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 3.7 | GO:0043679 | axon terminus(GO:0043679) |
| 0.0 | 3.7 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 3.5 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 3.5 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 3.3 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 3.1 | GO:0043204 | perikaryon(GO:0043204) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 5.1 | GO:0004465 | lipoprotein lipase activity(GO:0004465) |
| 0.0 | 5.0 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 4.3 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 0.1 | 4.2 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 3.6 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 3.5 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.7 | 3.3 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 3.0 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.5 | 2.9 | GO:0005290 | L-histidine transmembrane transporter activity(GO:0005290) L-asparagine transmembrane transporter activity(GO:0015182) |
| 0.2 | 2.5 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 2.5 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.1 | 2.4 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 2.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 2.2 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.1 | 1.2 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 1.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.9 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 0.7 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.0 | 0.7 | PID BMP PATHWAY | BMP receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.1 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.3 | 2.5 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 2.1 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.2 | 2.0 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 1.5 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 1.4 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 1.2 | REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 0.0 | 1.2 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 1.1 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 1.0 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |