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PRJNA207719: Tissue specific transcriptome profiling
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Results for foxo3a
Z-value: 0.57
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Transcription factors associated with foxo3a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| foxo3a | dr11_v1_chr17_+_6793001_6793001 | 0.38 | 5.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_36378494 Show fit | 0.62 |
ENSDART00000058503
|
glycoprotein M6Aa |
|
| chr19_+_2275019 Show fit | 0.50 |
ENSDART00000136138
|
integrin, beta 8 |
|
| chr12_-_13886952 Show fit | 0.39 |
ENSDART00000110503
|
ADAM metallopeptidase domain 11 |
|
| chr15_+_8043751 Show fit | 0.39 |
ENSDART00000193701
|
cell adhesion molecule 2b |
|
| chr5_+_36611128 Show fit | 0.38 |
ENSDART00000097684
|
neuro-oncological ventral antigen 1 |
|
| chr11_-_44409856 Show fit | 0.33 |
ENSDART00000162886
|
interleukin 1 receptor accessory protein-like 1b |
|
| chr19_-_28367413 Show fit | 0.32 |
ENSDART00000079092
|
si:dkey-261i16.5 |
|
| chr3_-_28258462 Show fit | 0.32 |
ENSDART00000191573
|
RNA binding fox-1 homolog 1 |
|
| chr13_+_1100197 Show fit | 0.32 |
ENSDART00000139560
|
protein phosphatase 3, regulatory subunit B, alpha a |
|
| chr8_-_25011157 Show fit | 0.32 |
ENSDART00000078795
|
adenosylhomocysteinase-like 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of foxo3a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:0033627 | cell adhesion mediated by integrin(GO:0033627) |
| 0.1 | 0.3 | GO:0016322 | neuron remodeling(GO:0016322) |
| 0.1 | 0.3 | GO:0035313 | wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028) |
| 0.1 | 0.3 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.0 | 0.3 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 0.0 | 0.3 | GO:0060079 | excitatory postsynaptic potential(GO:0060079) |
| 0.0 | 0.3 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.1 | 0.2 | GO:0008582 | regulation of synaptic growth at neuromuscular junction(GO:0008582) axon regeneration at neuromuscular junction(GO:0014814) positive regulation of synaptic growth at neuromuscular junction(GO:0045887) |
| 0.1 | 0.2 | GO:0018406 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.0 | 0.2 | GO:0006844 | acyl carnitine transport(GO:0006844) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.6 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 0.5 | GO:0008305 | integrin complex(GO:0008305) |
| 0.0 | 0.4 | GO:0042583 | chromaffin granule(GO:0042583) |
| 0.0 | 0.3 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 0.2 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 0.1 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 0.0 | 0.1 | GO:0034271 | phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272) |
| 0.0 | 0.1 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 0.1 | GO:0034451 | centriolar satellite(GO:0034451) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.1 | 0.3 | GO:0050135 | NAD(P)+ nucleosidase activity(GO:0050135) |
| 0.1 | 0.3 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.0 | 0.3 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.1 | 0.2 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.0 | 0.2 | GO:0044736 | acid-sensing ion channel activity(GO:0044736) |
| 0.0 | 0.2 | GO:0015227 | acyl carnitine transmembrane transporter activity(GO:0015227) |
| 0.0 | 0.2 | GO:0000340 | RNA 7-methylguanosine cap binding(GO:0000340) |
| 0.0 | 0.2 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.0 | 0.1 | GO:0008545 | JUN kinase kinase activity(GO:0008545) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.2 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 0.1 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.0 | 0.2 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 0.1 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |