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PRJNA207719: Tissue specific transcriptome profiling
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Results for foxm1
Z-value: 1.65
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Transcription factors associated with foxm1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| foxm1 | dr11_v1_chr4_-_5826320_5826320 | 0.77 | 1.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_+_23770666 Show fit | 1.13 |
ENSDART00000182493
|
si:ch211-219a4.3 |
|
| chr25_-_22187397 Show fit | 1.09 |
ENSDART00000123211
ENSDART00000139110 |
plakophilin 3a |
|
| chr19_+_48164242 Show fit | 1.09 |
ENSDART00000186574
|
PR domain containing 1b, with ZNF domain |
|
| chr15_-_41762530 Show fit | 0.89 |
ENSDART00000187125
ENSDART00000154971 |
finTRIM family, member 91 |
|
| chr3_-_19561058 Show fit | 0.87 |
ENSDART00000079323
|
zgc:163079 |
|
| chr22_+_835728 Show fit | 0.84 |
ENSDART00000003325
|
DENN/MADD domain containing 2Db |
|
| chr16_+_21801277 Show fit | 0.78 |
ENSDART00000088407
|
tripartite motif containing 108 |
|
| chr3_+_1167026 Show fit | 0.74 |
ENSDART00000031823
ENSDART00000155340 |
TRIO and F-actin binding protein b |
|
| chr5_-_38197080 Show fit | 0.71 |
ENSDART00000140708
|
si:ch211-284e13.9 |
|
| chr22_-_17671348 Show fit | 0.71 |
ENSDART00000137995
|
tight junction protein 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of foxm1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | GO:0040016 | embryonic cleavage(GO:0040016) |
| 0.2 | 0.7 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
| 0.1 | 0.7 | GO:1900407 | regulation of cellular response to oxidative stress(GO:1900407) |
| 0.1 | 0.7 | GO:0030104 | water homeostasis(GO:0030104) |
| 0.0 | 0.7 | GO:0045880 | positive regulation of smoothened signaling pathway(GO:0045880) |
| 0.0 | 0.7 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.1 | 0.6 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
| 0.0 | 0.6 | GO:0031297 | replication fork processing(GO:0031297) |
| 0.0 | 0.6 | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092) |
| 0.0 | 0.6 | GO:0030261 | chromosome condensation(GO:0030261) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | GO:0035101 | FACT complex(GO:0035101) |
| 0.1 | 1.1 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 1.1 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 0.7 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 0.6 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 0.6 | GO:0000779 | condensed chromosome, centromeric region(GO:0000779) |
| 0.0 | 0.5 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 0.5 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.1 | 0.4 | GO:0033186 | CAF-1 complex(GO:0033186) |
| 0.0 | 0.4 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.0 | 1.2 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 1.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.2 | 0.7 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.0 | 0.7 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 0.6 | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
| 0.0 | 0.6 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.1 | 0.5 | GO:0004373 | glycogen (starch) synthase activity(GO:0004373) |
| 0.1 | 0.5 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.0 | 0.5 | GO:0034062 | DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.1 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.0 | 0.7 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 0.4 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 0.3 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.2 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.2 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
| 0.0 | 0.1 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 0.7 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 0.6 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.0 | 0.6 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 0.5 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.1 | 0.4 | REACTOME ACYL CHAIN REMODELLING OF PI | Genes involved in Acyl chain remodelling of PI |
| 0.0 | 0.4 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 0.4 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.0 | 0.4 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.0 | 0.3 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |