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PRJNA207719: Tissue specific transcriptome profiling
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Results for foxj1a+foxj1b
Z-value: 1.22
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Transcription factors associated with foxj1a+foxj1b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| foxj1b | dr11_v1_chr12_+_20149305_20149311 | -0.92 | 2.6e-02 | Click! |
| foxj1a | dr11_v1_chr3_+_60721342_60721342 | -0.90 | 3.9e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_7391400 Show fit | 1.60 |
ENSDART00000169111
ENSDART00000186395 |
troponin I4a |
|
| chr4_+_7391110 Show fit | 1.48 |
ENSDART00000160708
ENSDART00000187823 |
troponin I4a |
|
| chr1_+_53945934 Show fit | 1.39 |
ENSDART00000052838
|
actin, alpha 1a, skeletal muscle |
|
| chr23_-_5683147 Show fit | 0.94 |
ENSDART00000102766
ENSDART00000067351 |
troponin T type 2a (cardiac) |
|
| chr21_-_22951604 Show fit | 0.89 |
ENSDART00000083449
ENSDART00000180129 |
duboraya |
|
| chr21_+_10577527 Show fit | 0.84 |
ENSDART00000165070
ENSDART00000127963 |
collagen and calcium binding EGF domains 1 |
|
| chr25_-_13188678 Show fit | 0.72 |
ENSDART00000125754
|
si:ch211-147m6.1 |
|
| chr22_+_19553390 Show fit | 0.68 |
ENSDART00000061739
|
hydroxysteroid (11-beta) dehydrogenase 1-like a |
|
| chr12_+_17100021 Show fit | 0.63 |
ENSDART00000177923
|
actin, alpha 2, smooth muscle, aorta |
|
| chr18_+_35842933 Show fit | 0.58 |
ENSDART00000151587
ENSDART00000131121 |
protein phosphatase 1, regulatory subunit 13 like |
Network of associatons between targets according to the STRING database.
First level regulatory network of foxj1a+foxj1b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.1 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.7 | 2.0 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 0.3 | 0.9 | GO:0061341 | non-canonical Wnt signaling pathway involved in heart development(GO:0061341) |
| 0.2 | 0.9 | GO:0003228 | atrial cardiac muscle tissue development(GO:0003228) |
| 0.0 | 0.9 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 0.1 | 0.8 | GO:0060855 | venous endothelial cell migration involved in lymph vessel development(GO:0060855) |
| 0.1 | 0.7 | GO:0045824 | negative regulation of toll-like receptor signaling pathway(GO:0034122) negative regulation of innate immune response(GO:0045824) |
| 0.0 | 0.7 | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) |
| 0.0 | 0.7 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.0 | 0.6 | GO:1904263 | positive regulation of TORC1 signaling(GO:1904263) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.0 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 2.0 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.0 | 0.8 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 0.7 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 0.7 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 0.7 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 0.5 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.1 | 0.4 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 0.0 | 0.4 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.0 | 0.4 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:0030172 | troponin C binding(GO:0030172) troponin I binding(GO:0031013) |
| 0.0 | 0.9 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 0.8 | GO:0003724 | RNA helicase activity(GO:0003724) |
| 0.0 | 0.7 | GO:0016229 | steroid dehydrogenase activity(GO:0016229) |
| 0.1 | 0.5 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.1 | 0.5 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 0.1 | 0.5 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 0.0 | 0.5 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.1 | 0.4 | GO:0004736 | pyruvate carboxylase activity(GO:0004736) |
| 0.1 | 0.4 | GO:0070643 | vitamin D 25-hydroxylase activity(GO:0070643) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 0.6 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 0.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.4 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 0.3 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 0.2 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.2 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.0 | 0.6 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.5 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.0 | 0.4 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 0.4 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.0 | 0.4 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 0.3 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.3 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 0.3 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 0.2 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |