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PRJNA207719: Tissue specific transcriptome profiling
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Results for foxf1+foxf2a+foxf2b
Z-value: 0.80
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Transcription factors associated with foxf1+foxf2a+foxf2b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| foxf2b | dr11_v1_chr20_+_26690036_26690036 | 0.30 | 6.2e-01 | Click! |
| foxf1 | dr11_v1_chr18_+_30847237_30847237 | -0.14 | 8.2e-01 | Click! |
| foxf2a | dr11_v1_chr2_-_716426_716426 | 0.04 | 9.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr25_+_31276842 Show fit | 0.58 |
ENSDART00000187238
|
troponin I type 2a (skeletal, fast), tandem duplicate 4 |
|
| chr5_+_32222303 Show fit | 0.51 |
ENSDART00000051362
|
myosin heavy chain 4 |
|
| chr12_-_17712393 Show fit | 0.47 |
ENSDART00000143534
ENSDART00000010144 |
parvalbumin 2 |
|
| chr10_+_36650222 Show fit | 0.39 |
ENSDART00000126963
|
uncoupling protein 3 |
|
| chr5_+_37837245 Show fit | 0.38 |
ENSDART00000171617
|
ependymin |
|
| chr25_+_31277415 Show fit | 0.38 |
ENSDART00000036275
|
troponin I type 2a (skeletal, fast), tandem duplicate 4 |
|
| chr14_+_51098036 Show fit | 0.37 |
ENSDART00000184118
|
|
|
| chr15_-_20933574 Show fit | 0.37 |
ENSDART00000152648
ENSDART00000152448 ENSDART00000152244 |
ubiquitin specific peptidase 2a |
|
| chr1_+_41849152 Show fit | 0.34 |
ENSDART00000053685
|
spermine oxidase |
|
| chr25_+_29160102 Show fit | 0.33 |
ENSDART00000162854
|
pyruvate kinase M1/2b |
Network of associatons between targets according to the STRING database.
First level regulatory network of foxf1+foxf2a+foxf2b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.0 | 0.7 | GO:0046883 | regulation of hormone secretion(GO:0046883) |
| 0.0 | 0.4 | GO:1990845 | adaptive thermogenesis(GO:1990845) |
| 0.0 | 0.4 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
| 0.1 | 0.3 | GO:0016322 | neuron remodeling(GO:0016322) |
| 0.0 | 0.3 | GO:0044211 | CTP salvage(GO:0044211) |
| 0.0 | 0.3 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.1 | 0.2 | GO:0002074 | extraocular skeletal muscle development(GO:0002074) |
| 0.1 | 0.2 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 0.0 | 0.2 | GO:1900619 | acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 0.8 | GO:0030141 | secretory granule(GO:0030141) |
| 0.0 | 0.5 | GO:1902710 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
| 0.0 | 0.5 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 0.3 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.0 | 0.3 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.0 | 0.2 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 0.2 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.0 | 0.2 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 0.1 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.1 | 0.4 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 0.1 | 0.3 | GO:0033857 | inositol heptakisphosphate kinase activity(GO:0000829) diphosphoinositol-pentakisphosphate kinase activity(GO:0033857) |
| 0.1 | 0.3 | GO:0046592 | polyamine oxidase activity(GO:0046592) |
| 0.1 | 0.3 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.0 | 0.3 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.0 | 0.3 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.1 | 0.2 | GO:0070643 | vitamin D 25-hydroxylase activity(GO:0070643) |
| 0.0 | 0.2 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.0 | 0.2 | GO:0008427 | calcium-dependent protein kinase inhibitor activity(GO:0008427) calcium-dependent protein kinase regulator activity(GO:0010858) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.1 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 0.3 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 0.3 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 0.2 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 0.1 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |