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PRJNA207719: Tissue specific transcriptome profiling
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Results for foxd3
Z-value: 1.75
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Transcription factors associated with foxd3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| foxd3 | dr11_v1_chr6_-_32093830_32093830 | -0.03 | 9.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_30839763 Show fit | 1.44 |
ENSDART00000154228
|
SH3-domain GRB2-like (endophilin) interacting protein 1a |
|
| chr7_+_21787507 Show fit | 0.80 |
ENSDART00000100936
|
transmembrane protein 88 b |
|
| chr22_+_24559947 Show fit | 0.75 |
ENSDART00000169847
|
WD repeat domain 47b |
|
| chr4_-_6567355 Show fit | 0.74 |
ENSDART00000134820
ENSDART00000142087 |
forkhead box P2 |
|
| chr5_+_36768674 Show fit | 0.73 |
ENSDART00000146854
|
MAP/microtubule affinity-regulating kinase 4a |
|
| chr18_-_23875370 Show fit | 0.64 |
ENSDART00000130163
|
nuclear receptor subfamily 2, group F, member 2 |
|
| chr1_+_2190714 Show fit | 0.63 |
ENSDART00000132126
|
muscleblind-like splicing regulator 2 |
|
| chr3_-_56924654 Show fit | 0.62 |
ENSDART00000157038
|
HID1 domain containing a |
|
| chr11_-_3646793 Show fit | 0.60 |
ENSDART00000077344
|
inter-alpha-trypsin inhibitor heavy chain 1 |
|
| chr4_+_7391400 Show fit | 0.59 |
ENSDART00000169111
ENSDART00000186395 |
troponin I4a |
Network of associatons between targets according to the STRING database.
First level regulatory network of foxd3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 1.8 | GO:0046883 | regulation of hormone secretion(GO:0046883) |
| 0.1 | 1.6 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.5 | 1.4 | GO:0060838 | lymphatic endothelial cell fate commitment(GO:0060838) venous endothelial cell differentiation(GO:0060843) venous endothelial cell fate commitment(GO:0060845) |
| 0.0 | 1.2 | GO:0090090 | negative regulation of canonical Wnt signaling pathway(GO:0090090) |
| 0.0 | 1.2 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.1 | 1.1 | GO:0045471 | response to ethanol(GO:0045471) |
| 0.0 | 1.1 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.0 | 1.0 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.1 | 0.9 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | GO:0030141 | secretory granule(GO:0030141) |
| 0.0 | 1.4 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 1.2 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 1.2 | GO:0030427 | site of polarized growth(GO:0030427) |
| 0.0 | 0.8 | GO:0031680 | G-protein beta/gamma-subunit complex(GO:0031680) |
| 0.0 | 0.7 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 0.7 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.1 | 0.6 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.0 | 0.6 | GO:0008305 | integrin complex(GO:0008305) |
| 0.0 | 0.5 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.4 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 1.4 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.1 | 1.2 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.0 | 1.0 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.0 | 1.0 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 0.9 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 0.8 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.1 | 0.7 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.0 | 0.7 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 0.7 | GO:0005178 | integrin binding(GO:0005178) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 1.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.9 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 0.7 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.0 | 0.6 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 0.6 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 0.5 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.4 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 0.4 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 0.4 | PID MTOR 4PATHWAY | mTOR signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.9 | REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR | Genes involved in Prostacyclin signalling through prostacyclin receptor |
| 0.0 | 0.7 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 0.5 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 0.5 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.4 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 0.3 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 0.3 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.0 | 0.3 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |