ISMARA results: foxd2

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PRJNA207719: Tissue specific transcriptome profiling

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Results for foxd2_foxd5

Z-value: 1.94

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Transcription factors associated with foxd2_foxd5

Gene Symbol	Gene ID	Gene Info
foxd2 NCBI UniProt	ENSDARG00000058133	forkhead box D2
foxd5 NCBI UniProt	ENSDARG00000042485	forkhead box D5
foxd5 NCBI UniProt	ENSDARG00000109712	forkhead box D5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
foxd2	dr11_v1_chr8_+_19674369_19674369	-0.71	1.8e-01	Click!
foxd5	dr11_v1_chr8_+_30452945_30452945	-0.70	1.9e-01	Click!

Activity profile of foxd2_foxd5 motif

Sorted Z-values of foxd2_foxd5 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_+_34127005 Show fit	2.89	ENSDART00000167384 ENSDART00000078065	f5 NCBI UniProt Show fit	coagulation factor V
chr14_+_21107032 Show fit	2.66	ENSDART00000138319 ENSDART00000139103 ENSDART00000184735	aldob NCBI UniProt Show fit	aldolase b, fructose-bisphosphate
chr4_-_25215968 Show fit	2.37	ENSDART00000066932 ENSDART00000066933	itih2 NCBI UniProt Show fit	inter-alpha-trypsin inhibitor heavy chain 2
chr14_+_11458044 Show fit	2.31	ENSDART00000186425	si:ch211-153b23.5 NCBI UniProt Show fit	si:ch211-153b23.5
chr18_-_46354269 Show fit	2.15	ENSDART00000010813	foxa3 NCBI UniProt Show fit	forkhead box A3
chr14_+_11457500 Show fit	2.13	ENSDART00000169202	si:ch211-153b23.5 NCBI UniProt Show fit	si:ch211-153b23.5
chr12_-_22524388 Show fit	2.02	ENSDART00000020942	shbg NCBI UniProt Show fit	sex hormone-binding globulin
chr21_+_40092301 Show fit	1.90	ENSDART00000145150	serpinf2a NCBI UniProt Show fit	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2a
chr18_-_6803424 Show fit	1.77	ENSDART00000142647	si:dkey-266m15.5 NCBI UniProt Show fit	si:dkey-266m15.5
chr13_-_4707018 Show fit	1.69	ENSDART00000128422	oit3 NCBI UniProt Show fit	oncoprotein induced transcript 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of foxd2_foxd5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.7	GO:0010951	negative regulation of endopeptidase activity(GO:0010951)
0.0	3.0	GO:0007599	hemostasis(GO:0007599)
0.0	3.0	GO:0006914	autophagy(GO:0006914)
0.7	2.2	GO:0048785	hatching gland development(GO:0048785)
0.1	2.0	GO:0071222	cellular response to molecule of bacterial origin(GO:0071219) cellular response to lipopolysaccharide(GO:0071222)
0.1	1.8	GO:0030212	hyaluronan metabolic process(GO:0030212)
0.1	1.8	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1	1.5	GO:0035622	intrahepatic bile duct development(GO:0035622)
0.2	1.4	GO:0071305	vitamin D3 metabolic process(GO:0070640) cellular response to vitamin D(GO:0071305)
0.0	1.3	GO:0006956	complement activation(GO:0006956) protein activation cascade(GO:0072376)

Showing 1 to 10 of 64 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.5	GO:0005923	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.3	1.4	GO:0005797	Golgi medial cisterna(GO:0005797)
0.1	1.2	GO:0042555	MCM complex(GO:0042555)
0.1	1.0	GO:0032019	mitochondrial cloud(GO:0032019)
0.1	0.9	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.1	0.9	GO:0031680	G-protein beta/gamma-subunit complex(GO:0031680)
0.0	0.9	GO:0016342	catenin complex(GO:0016342)
0.2	0.8	GO:0071540	eukaryotic translation initiation factor 3 complex, eIF3e(GO:0071540)
0.1	0.7	GO:0001772	immunological synapse(GO:0001772)
0.0	0.7	GO:0000792	heterochromatin(GO:0000792)

Showing 1 to 10 of 21 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.7	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	2.9	GO:0005507	copper ion binding(GO:0005507)
0.0	2.6	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	2.3	GO:0005125	cytokine activity(GO:0005125)
0.3	2.2	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	1.9	GO:0008395	steroid hydroxylase activity(GO:0008395)
0.0	1.6	GO:0019904	protein domain specific binding(GO:0019904)
0.0	1.3	GO:0042562	hormone binding(GO:0042562)
0.3	1.2	GO:0070643	vitamin D 25-hydroxylase activity(GO:0070643)
0.0	1.2	GO:0003688	DNA replication origin binding(GO:0003688)

Showing 1 to 10 of 51 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.8	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	3.9	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	2.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	1.9	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	1.3	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	0.5	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	0.5	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	0.4	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.4	PID AURORA B PATHWAY	Aurora B signaling
0.0	0.3	PID ALK1 PATHWAY	ALK1 signaling events

Showing 1 to 10 of 12 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.1	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.3	2.9	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.3	2.7	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	2.7	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.6	2.5	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.1	2.2	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.1	2.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.1	1.2	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1	1.0	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.0	0.5	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex

Showing 1 to 10 of 20 entries

Results for foxd2_foxd5

Z-value: 1.94

Motif logo

Transcription factors associated with foxd2_foxd5

Activity-expression correlation:

Activity profile of foxd2_foxd5 motif

Sorted Z-values of foxd2_foxd5 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of foxd2_foxd5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: