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PRJNA207719: Tissue specific transcriptome profiling
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Results for foxb1b+foxb2
Z-value: 1.51
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Transcription factors associated with foxb1b+foxb2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| foxb2 | dr11_v1_chr8_-_38506339_38506339 | 0.84 | 7.6e-02 | Click! |
| foxb1b | dr11_v1_chr7_+_29461060_29461060 | 0.45 | 4.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr23_-_19953089 Show fit | 1.57 |
ENSDART00000153828
|
ATPase plasma membrane Ca2+ transporting 3b |
|
| chr2_-_8017579 Show fit | 1.28 |
ENSDART00000040209
|
eph receptor B3a |
|
| chr6_+_40671336 Show fit | 1.20 |
ENSDART00000111639
ENSDART00000186617 |
arginine-glutamic acid dipeptide (RE) repeats b |
|
| chr12_+_28367557 Show fit | 1.18 |
ENSDART00000066294
|
cyclin-dependent kinase 5, regulatory subunit 1b (p35) |
|
| chr21_+_11684830 Show fit | 1.08 |
ENSDART00000147473
|
proprotein convertase subtilisin/kexin type 1 |
|
| chr23_-_29502287 Show fit | 1.03 |
ENSDART00000141075
ENSDART00000053807 |
kinesin family member 1B |
|
| chr21_+_11685009 Show fit | 1.02 |
ENSDART00000014668
|
proprotein convertase subtilisin/kexin type 1 |
|
| chr7_+_22823889 Show fit | 1.01 |
ENSDART00000127467
ENSDART00000148576 ENSDART00000149993 |
phosphorylase, glycogen, muscle b |
|
| chr1_+_16127825 Show fit | 0.96 |
ENSDART00000122503
|
tumor suppressor candidate 3 |
|
| chr23_-_3703569 Show fit | 0.95 |
ENSDART00000143731
|
protein kinase C and casein kinase substrate in neurons 1a |
Network of associatons between targets according to the STRING database.
First level regulatory network of foxb1b+foxb2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.1 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.7 | 2.1 | GO:0048917 | posterior lateral line ganglion development(GO:0048917) |
| 0.1 | 2.1 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.3 | 1.8 | GO:0035881 | amacrine cell differentiation(GO:0035881) |
| 0.0 | 1.7 | GO:0021854 | hypothalamus development(GO:0021854) |
| 0.0 | 1.6 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.0 | 1.4 | GO:0034446 | substrate adhesion-dependent cell spreading(GO:0034446) |
| 0.0 | 1.3 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
| 0.0 | 1.3 | GO:0016358 | dendrite development(GO:0016358) |
| 0.0 | 1.2 | GO:0035622 | intrahepatic bile duct development(GO:0035622) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.5 | GO:0043005 | neuron projection(GO:0043005) |
| 0.0 | 3.0 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 2.5 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 2.3 | GO:0030133 | transport vesicle(GO:0030133) |
| 0.0 | 2.2 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.4 | 2.0 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.0 | 1.6 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.0 | 1.1 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 1.0 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.1 | 0.9 | GO:0005955 | calcineurin complex(GO:0005955) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.1 | 2.1 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.2 | 2.0 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 0.1 | 1.9 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.1 | 1.6 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.1 | 1.5 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 1.5 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.0 | 1.1 | GO:0005178 | integrin binding(GO:0005178) |
| 0.2 | 1.0 | GO:0004645 | phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184) |
| 0.0 | 1.0 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 0.9 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.9 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 0.8 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 0.7 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 0.6 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 0.6 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 0.6 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 0.5 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 0.5 | PID ARF6 PATHWAY | Arf6 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.1 | REACTOME PEPTIDE HORMONE BIOSYNTHESIS | Genes involved in Peptide hormone biosynthesis |
| 0.1 | 1.0 | REACTOME SIGNALLING TO P38 VIA RIT AND RIN | Genes involved in Signalling to p38 via RIT and RIN |
| 0.1 | 0.9 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.2 | 0.8 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 0.6 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.1 | 0.6 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.1 | 0.6 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.6 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 0.6 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.5 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |