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PRJNA207719: Tissue specific transcriptome profiling
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Results for foxb1a
Z-value: 0.66
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Transcription factors associated with foxb1a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| foxb1a | dr11_v1_chr25_-_34156152_34156152 | 0.93 | 2.4e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_35446110 Show fit | 0.70 |
ENSDART00000058773
|
regulator of G protein signaling 16 |
|
| chr18_-_39702327 Show fit | 0.65 |
ENSDART00000149158
|
Dmx-like 2 |
|
| chr22_+_20195280 Show fit | 0.59 |
ENSDART00000088603
ENSDART00000135692 |
si:dkey-110c1.7 |
|
| chr23_-_27633730 Show fit | 0.56 |
ENSDART00000103639
|
ADP-ribosylation factor 3a |
|
| chr19_-_31522625 Show fit | 0.55 |
ENSDART00000158438
ENSDART00000035049 |
N-terminal EF-hand calcium binding protein 1 |
|
| chr16_-_43025885 Show fit | 0.55 |
ENSDART00000193146
ENSDART00000157302 |
si:dkey-7j14.5 |
|
| chr12_+_48480632 Show fit | 0.53 |
ENSDART00000158157
|
Rho GTPase activating protein 44 |
|
| chr7_+_30875273 Show fit | 0.53 |
ENSDART00000173693
|
amyloid beta (A4) precursor protein-binding, family A, member 2b |
|
| chr6_-_51101834 Show fit | 0.51 |
ENSDART00000092493
|
protein tyrosine phosphatase, receptor type, t |
|
| chr11_-_29082175 Show fit | 0.48 |
ENSDART00000123245
|
immunoglobin superfamily, member 21a |
Network of associatons between targets according to the STRING database.
First level regulatory network of foxb1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.2 | 0.6 | GO:0032847 | regulation of cellular pH reduction(GO:0032847) synaptic vesicle lumen acidification(GO:0097401) regulation of synaptic vesicle lumen acidification(GO:1901546) |
| 0.1 | 0.6 | GO:0016081 | synaptic vesicle docking(GO:0016081) presynaptic dense core granule exocytosis(GO:0099525) |
| 0.1 | 0.5 | GO:0099548 | trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by nitric oxide(GO:0099548) |
| 0.1 | 0.5 | GO:0042984 | amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984) |
| 0.0 | 0.5 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 0.0 | 0.5 | GO:0051923 | sulfation(GO:0051923) |
| 0.0 | 0.5 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.0 | 0.4 | GO:0001964 | startle response(GO:0001964) |
| 0.0 | 0.4 | GO:0015693 | magnesium ion transport(GO:0015693) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | GO:0098831 | presynaptic active zone cytoplasmic component(GO:0098831) |
| 0.2 | 0.6 | GO:0043291 | RAVE complex(GO:0043291) |
| 0.1 | 0.4 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 0.4 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.0 | 0.4 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 0.3 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 0.2 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.0 | 0.1 | GO:0034271 | phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272) |
| 0.0 | 0.1 | GO:0005673 | transcription factor TFIIE complex(GO:0005673) |
| 0.0 | 0.1 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 0.5 | GO:0005165 | nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165) |
| 0.0 | 0.5 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 0.5 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 0.4 | GO:0000340 | RNA 7-methylguanosine cap binding(GO:0000340) |
| 0.0 | 0.4 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472) |
| 0.1 | 0.3 | GO:0004419 | hydroxymethylglutaryl-CoA lyase activity(GO:0004419) |
| 0.0 | 0.3 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.0 | 0.3 | GO:0098882 | structural constituent of presynaptic active zone(GO:0098882) |
| 0.0 | 0.3 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 0.4 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.3 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.3 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.2 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.2 | PID CONE PATHWAY | Visual signal transduction: Cones |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.5 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 0.3 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.2 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 0.1 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.1 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |