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PRJNA207719: Tissue specific transcriptome profiling
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Results for fosaa+fosab+fosl1a
Z-value: 1.62
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Transcription factors associated with fosaa+fosab+fosl1a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| fosab | dr11_v1_chr20_-_46554440_46554440 | 0.28 | 6.5e-01 | Click! |
| fosl1a | dr11_v1_chr14_-_30747686_30747686 | -0.02 | 9.7e-01 | Click! |
| fosaa | dr11_v1_chr17_-_50233493_50233493 | -0.01 | 9.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_6514962 Show fit | 0.99 |
ENSDART00000163514
|
DnaJ (Hsp40) homolog, subfamily C, member 5 gamma b |
|
| chr3_-_25377163 Show fit | 0.72 |
ENSDART00000055490
|
karyopherin alpha 2 (RAG cohort 1, importin alpha 1) |
|
| chr16_+_26012569 Show fit | 0.63 |
ENSDART00000148846
|
protease, serine, 59, tandem duplicate 1 |
|
| chr17_+_20923691 Show fit | 0.58 |
ENSDART00000122407
|
cyclin-dependent kinase 1 |
|
| chr7_+_34794829 Show fit | 0.58 |
ENSDART00000009698
ENSDART00000075089 ENSDART00000173456 |
epithelial splicing regulatory protein 2 |
|
| chr6_-_55297274 Show fit | 0.57 |
ENSDART00000184283
|
ubiquitin-conjugating enzyme E2C |
|
| chr20_-_2641233 Show fit | 0.54 |
ENSDART00000145335
ENSDART00000133121 |
BUB1 mitotic checkpoint serine/threonine kinase |
|
| chr21_-_5077715 Show fit | 0.50 |
ENSDART00000081954
|
HAUS augmin-like complex, subunit 1 |
|
| chr6_+_56147812 Show fit | 0.50 |
ENSDART00000150219
|
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) |
|
| chr11_+_29537756 Show fit | 0.49 |
ENSDART00000103388
|
wu:fi42e03 |
Network of associatons between targets according to the STRING database.
First level regulatory network of fosaa+fosab+fosl1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | GO:1902653 | cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653) |
| 0.1 | 1.2 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
| 0.0 | 1.2 | GO:1904029 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029) |
| 0.0 | 1.0 | GO:0051225 | spindle assembly(GO:0051225) |
| 0.2 | 0.8 | GO:0009794 | regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448) |
| 0.1 | 0.8 | GO:0042989 | sequestering of actin monomers(GO:0042989) |
| 0.0 | 0.8 | GO:0090307 | mitotic spindle assembly(GO:0090307) microtubule cytoskeleton organization involved in mitosis(GO:1902850) |
| 0.1 | 0.7 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.1 | 0.7 | GO:0014034 | neural crest cell fate commitment(GO:0014034) neural crest cell fate specification(GO:0014036) |
| 0.0 | 0.7 | GO:0030968 | endoplasmic reticulum unfolded protein response(GO:0030968) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 1.1 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 0.9 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.1 | 0.8 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.0 | 0.7 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 0.6 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.2 | 0.5 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.0 | 0.5 | GO:0000780 | condensed nuclear chromosome kinetochore(GO:0000778) condensed nuclear chromosome, centromeric region(GO:0000780) |
| 0.0 | 0.4 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.0 | 0.4 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 0.9 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.0 | 0.8 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 0.8 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.1 | 0.6 | GO:0019136 | deoxynucleoside kinase activity(GO:0019136) |
| 0.0 | 0.6 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.0 | 0.6 | GO:0061608 | nuclear import signal receptor activity(GO:0061608) |
| 0.0 | 0.6 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 0.5 | GO:0035173 | histone kinase activity(GO:0035173) |
| 0.1 | 0.5 | GO:0004051 | arachidonate 5-lipoxygenase activity(GO:0004051) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.0 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 1.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.2 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 0.7 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.6 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 0.6 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.0 | 0.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 0.5 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.5 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.5 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 1.5 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.0 | 1.4 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 1.3 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 0.9 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.0 | 0.8 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.0 | 0.8 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.1 | 0.7 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.1 | 0.7 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 0.7 | REACTOME PERK REGULATED GENE EXPRESSION | Genes involved in PERK regulated gene expression |