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PRJNA207719: Tissue specific transcriptome profiling
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Results for fli1b
Z-value: 2.03
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Transcription factors associated with fli1b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| fli1b | dr11_v1_chr16_+_42018367_42018367 | 0.87 | 5.3e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_38285671 Show fit | 2.38 |
ENSDART00000061432
|
chemokine (C-C motif) ligand 38, duplicate 4 |
|
| chr22_+_5687615 Show fit | 1.65 |
ENSDART00000133241
ENSDART00000019854 ENSDART00000138102 |
deoxyribonuclease 1 like 4, tandem duplicate 2 |
|
| chr5_-_42272517 Show fit | 1.57 |
ENSDART00000137692
ENSDART00000164363 |
si:ch211-207c6.2 |
|
| chr23_-_10175898 Show fit | 1.56 |
ENSDART00000146185
|
keratin 5 |
|
| chr14_-_9128919 Show fit | 1.52 |
ENSDART00000108641
|
SH2 domain containing 1A duplicate b |
|
| chr14_-_40797117 Show fit | 1.18 |
ENSDART00000122369
|
E74-like ETS transcription factor 1 |
|
| chr9_+_2499627 Show fit | 1.18 |
ENSDART00000160782
|
WAS/WASL interacting protein family, member 1a |
|
| chr19_-_19442983 Show fit | 1.11 |
ENSDART00000052649
|
sb:cb649 |
|
| chr16_-_51299061 Show fit | 1.10 |
ENSDART00000148677
|
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 4 |
|
| chr6_-_29195642 Show fit | 1.08 |
ENSDART00000078625
|
dermatopontin |
Network of associatons between targets according to the STRING database.
First level regulatory network of fli1b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.4 | GO:0002548 | monocyte chemotaxis(GO:0002548) |
| 0.0 | 2.9 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 0.0 | 2.2 | GO:0030041 | actin filament polymerization(GO:0030041) |
| 0.0 | 1.9 | GO:0050852 | T cell receptor signaling pathway(GO:0050852) |
| 0.0 | 1.9 | GO:0030834 | regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) |
| 0.1 | 1.8 | GO:0000737 | DNA catabolic process, endonucleolytic(GO:0000737) |
| 0.0 | 1.8 | GO:0071560 | transforming growth factor beta receptor signaling pathway(GO:0007179) response to transforming growth factor beta(GO:0071559) cellular response to transforming growth factor beta stimulus(GO:0071560) |
| 0.0 | 1.6 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 0.0 | 1.5 | GO:0030048 | actin filament-based movement(GO:0030048) |
| 0.3 | 1.4 | GO:0051148 | negative regulation of muscle cell differentiation(GO:0051148) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | GO:0005884 | actin filament(GO:0005884) |
| 0.2 | 2.5 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 2.5 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.0 | 1.6 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.2 | 1.3 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 0.1 | 1.2 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.0 | 1.1 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.0 | 1.0 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 0.8 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.0 | 0.8 | GO:0000118 | histone deacetylase complex(GO:0000118) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 4.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 3.4 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.0 | 2.1 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.2 | 1.8 | GO:0004530 | deoxyribonuclease I activity(GO:0004530) |
| 0.2 | 1.6 | GO:0036042 | long-chain fatty acyl-CoA binding(GO:0036042) |
| 0.1 | 1.4 | GO:0019211 | phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542) |
| 0.0 | 1.3 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.1 | 1.2 | GO:0004046 | aminoacylase activity(GO:0004046) |
| 0.3 | 1.1 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.8 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.6 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 1.4 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.1 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 0.9 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 0.7 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.7 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.7 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.7 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 1.3 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.1 | 1.0 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 0.8 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 0.8 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 0.7 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 0.7 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 0.7 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 0.7 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 0.6 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |