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PRJNA207719: Tissue specific transcriptome profiling
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Results for figla
Z-value: 2.27
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Transcription factors associated with figla
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| figla | dr11_v1_chr5_-_13848296_13848296 | -0.30 | 6.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_30404096 Show fit | 4.07 |
ENSDART00000103475
|
anterior gradient 2 |
|
| chr19_-_30403922 Show fit | 3.23 |
ENSDART00000181841
|
anterior gradient 2 |
|
| chr7_-_35066457 Show fit | 2.43 |
ENSDART00000058067
|
zgc:112160 |
|
| chr22_-_17677947 Show fit | 2.17 |
ENSDART00000139911
|
tight junction protein 3 |
|
| chr2_+_15612755 Show fit | 2.06 |
ENSDART00000003035
|
amylase, alpha 2A (pancreatic) |
|
| chr23_-_29824146 Show fit | 2.05 |
ENSDART00000020616
|
zgc:194189 |
|
| chr20_-_21672970 Show fit | 2.01 |
ENSDART00000133286
|
si:ch211-207i1.2 |
|
| chr4_+_5537101 Show fit | 1.99 |
ENSDART00000008692
|
si:dkey-14d8.7 |
|
| chr7_+_2455344 Show fit | 1.98 |
ENSDART00000172942
|
si:dkey-125e8.4 |
|
| chr5_-_29531948 Show fit | 1.94 |
ENSDART00000098360
|
arrestin domain containing 1a |
Network of associatons between targets according to the STRING database.
First level regulatory network of figla
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 7.3 | GO:0060575 | intestinal epithelial cell differentiation(GO:0060575) |
| 0.1 | 3.8 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 0.6 | 2.3 | GO:0009957 | epidermal cell fate specification(GO:0009957) |
| 0.2 | 2.2 | GO:0030104 | water homeostasis(GO:0030104) |
| 0.1 | 2.1 | GO:0060046 | binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
| 0.2 | 1.9 | GO:0051256 | mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231) mitotic spindle midzone assembly(GO:0051256) |
| 0.1 | 1.9 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.1 | 1.9 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.6 | 1.7 | GO:0030043 | actin filament fragmentation(GO:0030043) |
| 0.2 | 1.7 | GO:0001973 | adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.8 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.0 | 3.2 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 2.4 | GO:0034992 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 2.0 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 1.9 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.0 | 1.9 | GO:0030141 | secretory granule(GO:0030141) |
| 0.0 | 1.7 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.1 | 1.5 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.1 | 1.4 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.1 | 1.3 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.7 | GO:0042803 | protein homodimerization activity(GO:0042803) |
| 0.0 | 4.7 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 4.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 3.4 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.1 | 3.2 | GO:0031683 | G-protein beta/gamma-subunit complex binding(GO:0031683) |
| 0.0 | 2.4 | GO:0003823 | antigen binding(GO:0003823) |
| 0.1 | 2.1 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.4 | 1.9 | GO:1990756 | protein binding, bridging involved in substrate recognition for ubiquitination(GO:1990756) |
| 0.0 | 1.9 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) |
| 0.0 | 1.9 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 1.5 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.0 | 1.0 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.2 | 0.8 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 0.8 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 0.7 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.7 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 0.6 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 0.6 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | REACTOME G PROTEIN ACTIVATION | Genes involved in G-protein activation |
| 0.4 | 2.1 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.0 | 2.0 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 2.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 1.7 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 1.6 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 1.5 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.9 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 0.9 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 0.8 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |