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PRJNA207719: Tissue specific transcriptome profiling
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Results for fev+fli1a_erg_etv2
Z-value: 1.22
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Transcription factors associated with fev+fli1a_erg_etv2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000009242 | FEV transcription factor, ETS family member | |
| ENSDARG00000054632 | Fli-1 proto-oncogene, ETS transcription factor a | |
| ENSDARG00000077304 | ETS transcription factor ERG | |
| ENSDARG00000053868 | ETS variant transcription factor 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| fli1a | dr11_v1_chr18_+_48428713_48428713 | -0.47 | 4.2e-01 | Click! |
| etv2 | dr11_v1_chr16_-_42013858_42013858 | -0.29 | 6.4e-01 | Click! |
| fev | dr11_v1_chr9_-_11549379_11549379 | 0.24 | 7.0e-01 | Click! |
| erg | dr11_v1_chr10_-_167782_167782 | -0.21 | 7.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of fev+fli1a_erg_etv2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.1 | 2.6 | GO:0002548 | monocyte chemotaxis(GO:0002548) |
| 0.0 | 2.5 | GO:0050852 | T cell receptor signaling pathway(GO:0050852) |
| 0.0 | 2.3 | GO:0009617 | response to bacterium(GO:0009617) |
| 0.2 | 1.7 | GO:2001045 | negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 0.1 | 1.7 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.0 | 1.6 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.0 | 1.5 | GO:0043297 | apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830) |
| 0.0 | 1.4 | GO:0051607 | defense response to virus(GO:0051607) |
| 0.0 | 1.3 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 4.7 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 4.4 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.4 | 2.3 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 0.0 | 2.2 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 1.7 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.0 | 1.6 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.0 | 1.3 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 1.2 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 1.1 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 3.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 2.8 | GO:0017171 | serine-type peptidase activity(GO:0008236) serine hydrolase activity(GO:0017171) |
| 0.0 | 2.5 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.1 | 2.4 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.0 | 2.4 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.1 | 2.2 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.0 | 1.8 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.1 | 1.5 | GO:0072542 | phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542) |
| 0.0 | 1.4 | GO:0051082 | unfolded protein binding(GO:0051082) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.0 | 1.1 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 1.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 1.0 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 1.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 0.9 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 0.9 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 0.8 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.8 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.8 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.0 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 4.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 2.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 1.3 | REACTOME MEIOSIS | Genes involved in Meiosis |
| 0.1 | 1.2 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.3 | 1.1 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 0.9 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
| 0.3 | 0.8 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 0.8 | REACTOME HORMONE LIGAND BINDING RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.0 | 0.8 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |