ISMARA results: esrrd+esrrga_esrrb

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PRJNA207719: Tissue specific transcriptome profiling

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Results for esrrd+esrrga_esrrb_esrra+esrrgb

Z-value: 1.16

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Transcription factors associated with esrrd+esrrga_esrrb_esrra+esrrgb

Gene Symbol	Gene ID	Gene Info
esrrga NCBI UniProt	ENSDARG00000004861	estrogen-related receptor gamma a
esrrd NCBI UniProt	ENSDARG00000015064	estrogen-related receptor delta
esrrb NCBI UniProt	ENSDARG00000100847	estrogen-related receptor beta
esrrgb NCBI UniProt	ENSDARG00000011696	estrogen-related receptor gamma b
esrra NCBI UniProt	ENSDARG00000069266	estrogen-related receptor alpha

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
esrra	dr11_v1_chr21_+_26620867_26620867	0.93	2.4e-02	Click!
esrrb	dr11_v1_chr17_-_29877336_29877336	0.84	7.6e-02	Click!
esrrgb	dr11_v1_chr20_-_46817223_46817223	0.58	3.1e-01	Click!
esrrd	dr11_v1_chr18_-_48992363_48992363	0.08	8.9e-01	Click!

Activity profile of esrrd+esrrga_esrrb_esrra+esrrgb motif

Sorted Z-values of esrrd+esrrga_esrrb_esrra+esrrgb motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_+_2620751 Show fit	1.39	ENSDART00000013924	gpr22a NCBI UniProt Show fit	G protein-coupled receptor 22a
chr18_-_226800 Show fit	1.11	ENSDART00000165180	tarsl2 NCBI UniProt Show fit	threonyl-tRNA synthetase-like 2
chr2_-_24289641 Show fit	0.98	ENSDART00000128784 ENSDART00000123565 ENSDART00000141922 ENSDART00000184550 ENSDART00000191469	myh7l NCBI UniProt Show fit	myosin heavy chain 7-like
chr19_-_32487469 Show fit	0.92	ENSDART00000050130	gmpr NCBI UniProt Show fit	guanosine monophosphate reductase
chr14_-_33454595 Show fit	0.91	ENSDART00000109615 ENSDART00000173267 ENSDART00000185737 ENSDART00000190989	tmem255a NCBI UniProt Show fit	transmembrane protein 255A
chr3_+_39568290 Show fit	0.88	ENSDART00000020741	aldoaa NCBI UniProt Show fit	aldolase a, fructose-bisphosphate, a
chr7_+_67494107 Show fit	0.84	ENSDART00000185653	cpne7 NCBI UniProt Show fit	copine VII
chr11_+_30513656 Show fit	0.83	ENSDART00000008594	tmem178 NCBI UniProt Show fit	transmembrane protein 178
chr10_+_45128375 Show fit	0.83	ENSDART00000164805	camk2b2 NCBI UniProt Show fit	calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2
chr21_-_32487061 Show fit	0.83	ENSDART00000114359 ENSDART00000131591 ENSDART00000131477	si:dkeyp-72g9.4 NCBI UniProt Show fit	si:dkeyp-72g9.4

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of esrrd+esrrga_esrrb_esrra+esrrgb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.7	GO:0071277	cellular response to calcium ion(GO:0071277)
0.1	1.4	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	1.4	GO:0071907	determination of digestive tract left/right asymmetry(GO:0071907)
0.0	1.4	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.0	1.1	GO:0016185	synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0	1.1	GO:0071391	cellular response to estrogen stimulus(GO:0071391)
0.3	0.8	GO:0045671	negative regulation of osteoclast differentiation(GO:0045671)
0.1	0.8	GO:0006086	acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.1	0.8	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.8	GO:0030168	platelet activation(GO:0030168)

Showing 1 to 10 of 124 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.1	GO:0016459	myosin complex(GO:0016459)
0.1	0.9	GO:0098835	presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.3	0.8	GO:0098753	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) anchored component of the cytoplasmic side of the plasma membrane(GO:0098753)
0.3	0.8	GO:1902560	GMP reductase complex(GO:1902560)
0.1	0.8	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1	0.8	GO:0005967	mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1	0.8	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	0.8	GO:0005746	mitochondrial respiratory chain(GO:0005746)
0.0	0.7	GO:0031594	neuromuscular junction(GO:0031594)
0.1	0.5	GO:0045257	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)

Showing 1 to 10 of 41 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.1	0.9	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.9	GO:0030165	PDZ domain binding(GO:0030165)
0.0	0.9	GO:0001786	phosphatidylserine binding(GO:0001786)
0.3	0.8	GO:0003920	GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.2	0.8	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.1	0.8	GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0	0.8	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	0.8	GO:0008013	beta-catenin binding(GO:0008013)
0.0	0.8	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)

Showing 1 to 10 of 99 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
0.7	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.5	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.5	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.4	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.4	PID REELIN PATHWAY	Reelin signaling pathway
0.4	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.3	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.2	PID TRAIL PATHWAY	TRAIL signaling pathway
0.1	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.

Showing 1 to 9 of 9 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.9	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.1	0.8	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.6	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.0	0.5	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.0	0.5	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	0.5	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	0.5	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels
0.0	0.5	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.0	0.4	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	0.3	REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)

Showing 1 to 10 of 21 entries

Results for esrrd+esrrga_esrrb_esrra+esrrgb

Z-value: 1.16

Motif logo

Transcription factors associated with esrrd+esrrga_esrrb_esrra+esrrgb

Activity-expression correlation:

Activity profile of esrrd+esrrga_esrrb_esrra+esrrgb motif

Sorted Z-values of esrrd+esrrga_esrrb_esrra+esrrgb motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of esrrd+esrrga_esrrb_esrra+esrrgb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: