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PRJNA207719: Tissue specific transcriptome profiling

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Results for esr1+esr2a+esr2b

Z-value: 1.42

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Transcription factors associated with esr1+esr2a+esr2b

Gene Symbol Gene ID Gene Info
ENSDARG00000004111 estrogen receptor 1
ENSDARG00000016454 estrogen receptor 2a
ENSDARG00000034181 estrogen receptor 2b
ENSDARG00000112357 estrogen receptor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
esr2adr11_v1_chr20_+_21583639_215836390.701.8e-01Click!
esr2bdr11_v1_chr13_+_37022601_370226320.543.5e-01Click!
esr1dr11_v1_chr20_-_26382284_263822840.513.8e-01Click!

Activity profile of esr1+esr2a+esr2b motif

Sorted Z-values of esr1+esr2a+esr2b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_1317290 1.05 ENSDART00000047094

chr12_+_7491690 1.04 ENSDART00000152564
phytanoyl-CoA 2-hydroxylase interacting protein-like b
chr4_+_17280868 1.01 ENSDART00000145349
branched chain amino-acid transaminase 1, cytosolic
chr1_-_59176949 0.99 ENSDART00000128742

chr17_-_6738538 0.94 ENSDART00000157125
visinin-like 1b
chr24_-_38374744 0.90 ENSDART00000007208
leucine rich repeat containing 4Bb
chr5_-_23280098 0.89 ENSDART00000126540
ENSDART00000051533
proteolipid protein 1b
chr20_+_5564042 0.84 ENSDART00000090934
ENSDART00000127050
neurexin 3b
chr5_-_55395964 0.83 ENSDART00000145791
prune homolog 2 (Drosophila)
chr25_-_19374710 0.80 ENSDART00000184483
ENSDART00000188706
microtubule-associated protein 1Ab
chr6_+_36942966 0.78 ENSDART00000028895
neuronal growth regulator 1
chr2_+_34767171 0.77 ENSDART00000145451
astrotactin 1
chr15_+_19544052 0.76 ENSDART00000062560
zgc:77784
chr5_-_46980651 0.72 ENSDART00000181022
ENSDART00000168038
EGF-like repeats and discoidin I-like domains 3a
chr7_+_40228422 0.69 ENSDART00000052222
protein tyrosine phosphatase, receptor type, N polypeptide 2
chr12_+_35119762 0.68 ENSDART00000085774
si:ch73-127m5.1
chr6_-_11768198 0.68 ENSDART00000183463
membrane-associated ring finger (C3HC4) 7
chr2_+_18988407 0.67 ENSDART00000170216
glutamate-ammonia ligase (glutamine synthase) a
chr17_-_12385308 0.65 ENSDART00000080927
synaptosomal-associated protein, 25b
chr5_+_1278092 0.65 ENSDART00000147972
ENSDART00000159783
dynamin 1a
chr4_-_191736 0.63 ENSDART00000169187
ENSDART00000192054
protein tyrosine phosphatase, receptor type, O
chr6_+_48618512 0.62 ENSDART00000111190
si:dkey-238f9.1
chr12_+_9320783 0.62 ENSDART00000152526
potassium voltage-gated channel, subfamily H (eag-related), member 6b
chr9_+_4429593 0.59 ENSDART00000184855

chr9_+_4306122 0.58 ENSDART00000193722
ENSDART00000190521
kalirin RhoGEF kinase a
chr16_+_5774977 0.57 ENSDART00000134202
cholecystokinin a
chr7_+_20017211 0.57 ENSDART00000100808
B-cell CLL/lymphoma 6, member B
chr20_+_54738210 0.56 ENSDART00000151399
p21 protein (Cdc42/Rac)-activated kinase 7
chr6_-_60031693 0.55 ENSDART00000160275

chr9_-_31747106 0.55 ENSDART00000048469
ENSDART00000145204
ENSDART00000186889
sodium leak channel, non-selective
chr6_+_42587637 0.55 ENSDART00000179964
CaM kinase-like vesicle-associated a
chr3_+_17547532 0.54 ENSDART00000175485
ENSDART00000153763
potassium voltage-gated channel, subfamily H (eag-related), member 4a
chr4_+_15981096 0.54 ENSDART00000122493
urocortin 3, like
chr21_+_20901505 0.54 ENSDART00000132741
complement component 7b
chr6_+_3828560 0.53 ENSDART00000185273
ENSDART00000179091
glutamate decarboxylase 1b
chr2_-_30460293 0.53 ENSDART00000113193
cerebellin 2a precursor
chr6_+_12853655 0.52 ENSDART00000156341
family with sequence similarity 117, member Ba
chr8_-_49431939 0.52 ENSDART00000011453
ENSDART00000088240
ENSDART00000114173
synaptophysin b
chr2_-_31302615 0.52 ENSDART00000034784
ENSDART00000060812
adenylate cyclase activating polypeptide 1b
chr20_-_40717900 0.52 ENSDART00000181663
connexin 43
chr13_+_35746440 0.52 ENSDART00000187859
G protein-coupled receptor 75
chr6_+_10450000 0.52 ENSDART00000151288
ENSDART00000187431
ENSDART00000192474
ENSDART00000188214
ENSDART00000184766
ENSDART00000190082
potassium channel, voltage gated eag related subfamily H, member 7
chr6_-_9792004 0.51 ENSDART00000081129
cyclin-dependent kinase 15
chr5_+_23624684 0.51 ENSDART00000051539
connexin 27.5
chr18_-_226800 0.50 ENSDART00000165180
threonyl-tRNA synthetase-like 2
chr12_+_26670778 0.50 ENSDART00000144355
Rho GTPase activating protein 12b
chr16_+_52771199 0.50 ENSDART00000111383
brain and acute leukemia, cytoplasmic a
chr8_+_49778486 0.50 ENSDART00000131732
neurotrophic tyrosine kinase, receptor, type 2a
chr20_+_30490682 0.50 ENSDART00000184871
myelin transcription factor 1-like, a
chr5_+_64319590 0.50 ENSDART00000192652

chr19_-_9712530 0.49 ENSDART00000134816
solute carrier family 2 (facilitated glucose transporter), member 3a
chr18_-_14937211 0.49 ENSDART00000141893
megalencephalic leukoencephalopathy with subcortical cysts 1
chr12_-_48992527 0.49 ENSDART00000169696
cadherin related family member 1
chr7_+_34297271 0.49 ENSDART00000180342
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr5_+_70155935 0.49 ENSDART00000165570
regulator of G protein signaling 3a
chr15_+_47386939 0.49 ENSDART00000128224

chr3_-_6767440 0.48 ENSDART00000156174
microtubule associated serine/threonine kinase 1b
chr2_-_44720551 0.48 ENSDART00000146380
MAP6 domain containing 1
chr15_-_25518084 0.48 ENSDART00000158594
hypoxia-inducible factor 1, alpha subunit, like
chr5_-_31901468 0.47 ENSDART00000147814
ENSDART00000141446
coronin, actin binding protein, 1Cb
chr25_-_19420949 0.47 ENSDART00000181338
microtubule-associated protein 1Ab
chr1_-_30039331 0.47 ENSDART00000086935
ENSDART00000143800
zgc:153256
chr7_+_34296789 0.47 ENSDART00000052471
ENSDART00000173798
ENSDART00000173778
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr10_-_17103651 0.46 ENSDART00000108959
ring finger protein 208
chr21_-_1972236 0.46 ENSDART00000192858
ENSDART00000189962
ENSDART00000182461
ENSDART00000165547
WD repeat domain 7
chr7_+_26132665 0.46 ENSDART00000129834
N-acetyltransferase 16
chr3_-_30061985 0.46 ENSDART00000189583
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr10_+_10636237 0.46 ENSDART00000136853
family with sequence similarity 163, member B
chr13_-_31435137 0.46 ENSDART00000057441
reticulon 1a
chr14_-_42997145 0.46 ENSDART00000172801
protocadherin 10b
chr3_+_40170216 0.45 ENSDART00000011568
synaptogyrin 3a
chr1_-_44704261 0.45 ENSDART00000133210
si:dkey-28b4.8
chr13_-_33022372 0.44 ENSDART00000147165
RNA binding motif protein 25a
chr3_-_46811611 0.44 ENSDART00000134092
ELAV like neuron-specific RNA binding protein 3
chr23_+_44741500 0.44 ENSDART00000166421
ATPase Na+/K+ transporting subunit beta 2a
chr24_+_39186940 0.44 ENSDART00000155817
splA/ryanodine receptor domain and SOCS box containing 3b
chr22_-_13857729 0.44 ENSDART00000177971
S100 calcium binding protein, beta (neural)
chr5_+_29784172 0.43 ENSDART00000139035
si:ch211-215c18.3
chr23_-_15216654 0.43 ENSDART00000131649
sulfatase 2b
chr18_-_42313798 0.43 ENSDART00000098639
contactin 5
chr10_-_31782616 0.43 ENSDART00000128839
fasciculation and elongation protein zeta 1 (zygin I)
chr18_+_16330025 0.43 ENSDART00000142353
neurotensin
chr1_-_12278522 0.42 ENSDART00000142122
ENSDART00000003825
complexin 2, like
chr23_-_11870962 0.42 ENSDART00000143481
si:dkey-178k16.1
chr17_+_30448452 0.42 ENSDART00000153939
lipin 1
chr6_-_31348999 0.41 ENSDART00000153734
DnaJ (Hsp40) homolog, subfamily C, member 6
chr12_-_16084835 0.41 ENSDART00000090881
potassium voltage-gated channel, subfamily J, member 19b
chr19_-_32783373 0.41 ENSDART00000145790
5'-nucleotidase, cytosolic IAa
chr23_+_43954809 0.41 ENSDART00000164080
corin, serine peptidase
chr8_+_31821396 0.41 ENSDART00000077053
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr3_-_50124413 0.41 ENSDART00000189920
claudin k
chr3_-_27868183 0.41 ENSDART00000185812
4-aminobutyrate aminotransferase
chr6_+_13806466 0.41 ENSDART00000043522
transmembrane protein 198b
chr17_-_44968177 0.41 ENSDART00000075510
neuroglobin
chr8_+_24861264 0.40 ENSDART00000099607
solute carrier family 6 (neutral amino acid transporter), member 17
chr19_+_30662529 0.40 ENSDART00000175662
family with sequence similarity 49, member A-like
chr7_-_51476276 0.40 ENSDART00000082464
NHS-like 2
chr9_+_42095220 0.40 ENSDART00000148317
ENSDART00000134431
poly(rC) binding protein 3
chr2_-_38000276 0.40 ENSDART00000034790
Purkinje cell protein 4 like 1
chr11_+_25111846 0.39 ENSDART00000128705
ENSDART00000190058
ndrg family member 3a
chr18_+_45571378 0.39 ENSDART00000077251
kinesin family member C3
chr3_+_34821327 0.39 ENSDART00000055262
cyclin-dependent kinase 5, regulatory subunit 1a (p35)
chr9_+_29643036 0.38 ENSDART00000023210
ENSDART00000175160
tripartite motif containing 13
chr23_+_27912079 0.38 ENSDART00000171859

chr14_-_9982603 0.38 ENSDART00000054687
interleukin 1 receptor accessory protein-like 2
chr4_+_4849789 0.38 ENSDART00000130818
ENSDART00000127751
protein tyrosine phosphatase, receptor-type, Z polypeptide 1b
chr5_-_10768258 0.38 ENSDART00000157043
reticulon 4 receptor
chr3_-_36260102 0.38 ENSDART00000126588
Rac family small GTPase 3a
chr4_+_10366532 0.38 ENSDART00000189901
potassium voltage-gated channel, Shal-related subfamily, member 2
chr4_-_1360495 0.38 ENSDART00000164623
pleiotrophin
chr16_-_55028740 0.38 ENSDART00000156368
ENSDART00000161704
zgc:114181
chr23_-_21471022 0.38 ENSDART00000104206
hairy-related 4, tandem duplicate 2
chr3_+_23488652 0.37 ENSDART00000126282
nuclear receptor subfamily 1, group d, member 1
chr23_+_6232895 0.37 ENSDART00000139795
synaptotagmin IIa
chr3_-_27880229 0.37 ENSDART00000151404
4-aminobutyrate aminotransferase
chr8_+_14792830 0.37 ENSDART00000139972
calcium channel, voltage-dependent, R type, alpha 1E subunit a
chr18_-_16179129 0.37 ENSDART00000125353
solute carrier family 6 (neutral amino acid transporter), member 15
chr19_+_37701450 0.36 ENSDART00000087694
thrombospondin, type I, domain containing 7Aa
chr4_-_8152746 0.36 ENSDART00000012928
ENSDART00000177482
WNK lysine deficient protein kinase 1b
chr7_+_67494107 0.36 ENSDART00000185653
copine VII
chr3_+_13440900 0.36 ENSDART00000143715
si:dkey-117i10.1
chr3_-_18710009 0.35 ENSDART00000142478
glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein, a
chr2_-_44038698 0.35 ENSDART00000079582
ENSDART00000146804
kirre like nephrin family adhesion molecule 1b
chr3_+_33367954 0.35 ENSDART00000103161
membrane protein, palmitoylated 2a (MAGUK p55 subfamily member 2)
chr7_+_568819 0.35 ENSDART00000173716
neurexin 2b
chr9_-_20372977 0.35 ENSDART00000113418
immunoglobulin superfamily, member 3
chr21_+_10076203 0.34 ENSDART00000190383

chr18_+_38807239 0.34 ENSDART00000184332
family with sequence similarity 214, member A
chr18_+_8340886 0.34 ENSDART00000081132
carnitine palmitoyltransferase 1B (muscle)
chr5_-_29643381 0.34 ENSDART00000034849
glutamate receptor, ionotropic, N-methyl D-aspartate 1b
chr11_-_29650930 0.34 ENSDART00000166969
chromodomain helicase DNA binding protein 5
chr2_-_10062575 0.33 ENSDART00000091726
family with sequence similarity 78, member B a
chr1_-_17650223 0.33 ENSDART00000043484
si:dkey-256e7.5
chr24_-_31843173 0.33 ENSDART00000185782
STEAP family member 2, metalloreductase
chr19_-_874888 0.33 ENSDART00000007206
eomesodermin homolog a
chr20_-_25709247 0.33 ENSDART00000146711
si:dkeyp-117h8.2
chr4_-_7212875 0.32 ENSDART00000161297
leucine rich repeat neuronal 3b
chr20_-_29864390 0.32 ENSDART00000161834
ENSDART00000132278
ring finger protein 144ab
chr24_+_684924 0.32 ENSDART00000186103
si:ch211-188f17.1
chr16_+_5678071 0.32 ENSDART00000011166
ENSDART00000134198
ENSDART00000131575
zgc:158689
chr21_+_1119046 0.32 ENSDART00000184678

chr20_+_3108597 0.32 ENSDART00000133435
si:ch73-212j7.1
chr7_-_22132265 0.32 ENSDART00000125284
ENSDART00000112978
neuroligin 2a
chr1_-_38813679 0.32 ENSDART00000148917
ankyrin repeat and SOCS box containing 5b
chr13_-_31452516 0.32 ENSDART00000193268
reticulon 1a
chr20_-_42100932 0.32 ENSDART00000191930
solute carrier family 35, member F1
chr10_+_7563755 0.32 ENSDART00000165877
purine-rich element binding protein G
chr6_-_42112191 0.32 ENSDART00000085472
glutamate receptor, metabotropic 2a
chr6_-_47246948 0.32 ENSDART00000162435
glutamate receptor, metabotropic 4
chr11_+_30162407 0.32 ENSDART00000190333
ENSDART00000127502
cyclin-dependent kinase-like 5
chr1_-_23110740 0.31 ENSDART00000171848
ENSDART00000086797
ENSDART00000189344
ENSDART00000190858
adhesion G protein-coupled receptor L3.1
chr15_-_47838391 0.31 ENSDART00000180337
kelch repeat and BTB (POZ) domain containing 3
chr1_-_45920632 0.31 ENSDART00000140890
patatin-like phospholipase domain containing 6
chr8_+_24745041 0.31 ENSDART00000148872
solute carrier family 16, member 4
chr18_+_2837563 0.31 ENSDART00000171495
ENSDART00000160228
family with sequence similarity 168, member A
chr5_+_38276582 0.31 ENSDART00000158532
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr1_+_52563298 0.31 ENSDART00000142465
ATP-binding cassette, sub-family A (ABC1), member 1A
chr2_-_30611389 0.31 ENSDART00000142500
catenin (cadherin-associated protein), delta 2b
chr18_+_27515640 0.31 ENSDART00000181593
tumor protein p53 inducible protein 11b
chr22_-_7400471 0.31 ENSDART00000161215
si:dkey-57c15.1
chr1_+_59154521 0.31 ENSDART00000130089
ENSDART00000152456
heme-binding protein soul5, like
chr6_-_13308813 0.31 ENSDART00000065372
potassium inwardly-rectifying channel, subfamily J, member 3b
chr14_-_31465905 0.30 ENSDART00000173108
glypican 3
chr16_+_23923746 0.30 ENSDART00000137962
si:dkey-7f3.14
chr12_-_10220036 0.30 ENSDART00000134619
membrane protein, palmitoylated 2b (MAGUK p55 subfamily member 2)
chr5_+_43470544 0.30 ENSDART00000111587
Rho-related BTB domain containing 2a
chr12_-_3756405 0.30 ENSDART00000150839
family with sequence similarity 57, member Bb
chr20_-_39273987 0.30 ENSDART00000127173
clusterin
chr17_-_40397752 0.30 ENSDART00000178483

chr16_-_27138478 0.30 ENSDART00000147438
transmembrane protein 245
chr5_-_2282256 0.30 ENSDART00000064012
carbonic anhydrase IV a
chr5_-_25072607 0.30 ENSDART00000145061
patatin-like phospholipase domain containing 7b
chr25_+_16945348 0.30 ENSDART00000016591
fibroblast growth factor 6a
chr8_+_24854600 0.30 ENSDART00000156570
solute carrier family 6 (neutral amino acid transporter), member 17
chr22_+_18816662 0.29 ENSDART00000132476
calcium channel, voltage-dependent, beta subunit associated regulatory protein b
chr21_-_10446405 0.29 ENSDART00000167948
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
chr24_+_16393302 0.29 ENSDART00000188670
ENSDART00000081759
ENSDART00000177790
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr9_-_37613792 0.29 ENSDART00000138345
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Ba
chr8_+_25254435 0.29 ENSDART00000143554
adenosine monophosphate deaminase 2b
chr9_-_22821901 0.29 ENSDART00000101711
nebulin
chr18_-_15373620 0.29 ENSDART00000031752
regulatory factor X, 4
chr25_+_1591964 0.29 ENSDART00000093277
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr5_+_483965 0.29 ENSDART00000150007
TEK tyrosine kinase, endothelial
chr6_-_957830 0.29 ENSDART00000090019
ENSDART00000184286
zinc finger E-box binding homeobox 2b
chr13_-_9525527 0.29 ENSDART00000190618

chr22_-_18022416 0.29 ENSDART00000141563
neurocan b
chr10_+_37145007 0.29 ENSDART00000131777
CUE domain containing 1a
chr5_+_65491390 0.29 ENSDART00000159921
si:dkey-21e5.1
chr19_+_4916233 0.29 ENSDART00000159512
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr20_-_28638871 0.29 ENSDART00000184779
regulator of G protein signaling 6
chr21_-_131236 0.28 ENSDART00000160005
si:ch1073-398f15.1
chr16_-_27149202 0.28 ENSDART00000179726
transmembrane protein 245
chr5_+_24156170 0.28 ENSDART00000136570
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15b
chr6_-_31325400 0.28 ENSDART00000188869
DnaJ (Hsp40) homolog, subfamily C, member 6
chr6_+_49412754 0.28 ENSDART00000027398
potassium voltage-gated channel, shaker-related subfamily, member 2a
chr20_-_28768109 0.28 ENSDART00000114611
ENSDART00000182443
signal-induced proliferation-associated 1 like 1
chr1_-_55810730 0.28 ENSDART00000100551
zgc:136908
chr12_-_37653685 0.28 ENSDART00000085121
sidekick cell adhesion molecule 2b
chr18_-_40508528 0.28 ENSDART00000185249
cholinergic receptor, nicotinic, alpha 5
chr21_-_25756119 0.28 ENSDART00000002341
claudin c

Network of associatons between targets according to the STRING database.

First level regulatory network of esr1+esr2a+esr2b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.3 GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910)
0.3 1.1 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.2 1.0 GO:0009098 leucine biosynthetic process(GO:0009098)
0.2 0.5 GO:0055109 invagination involved in gastrulation with mouth forming second(GO:0055109) morphogenesis of an epithelial fold(GO:0060571)
0.2 0.5 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.2 0.5 GO:0099551 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.2 0.5 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823)
0.2 0.8 GO:0009450 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
0.1 0.7 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.1 1.0 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 0.4 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 0.5 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 0.3 GO:0000066 mitochondrial ornithine transport(GO:0000066) mitochondrial L-ornithine transmembrane transport(GO:1990575)
0.1 1.0 GO:0006797 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.1 0.3 GO:0051230 mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
0.1 0.5 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
0.1 0.3 GO:0015677 copper ion import(GO:0015677)
0.1 0.6 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.1 0.3 GO:0010874 regulation of cholesterol efflux(GO:0010874)
0.1 0.3 GO:0061031 endodermal digestive tract morphogenesis(GO:0061031)
0.1 0.5 GO:0035777 pronephric distal tubule development(GO:0035777)
0.1 0.9 GO:0014846 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.1 1.1 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.1 0.6 GO:0009437 carnitine metabolic process(GO:0009437)
0.1 0.5 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 1.1 GO:0022010 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.1 1.3 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.1 0.2 GO:0034036 sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.1 0.5 GO:0021794 thalamus development(GO:0021794)
0.0 0.2 GO:0048618 post-embryonic foregut morphogenesis(GO:0048618)
0.0 0.2 GO:0032615 interleukin-12 production(GO:0032615) regulation of interleukin-12 production(GO:0032655)
0.0 0.7 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.3 GO:0060251 regulation of glial cell proliferation(GO:0060251)
0.0 0.2 GO:0098957 anterograde axonal transport of mitochondrion(GO:0098957)
0.0 0.3 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.2 GO:0017185 peptidyl-lysine hydroxylation(GO:0017185)
0.0 0.3 GO:0045955 negative regulation of calcium ion-dependent exocytosis(GO:0045955) negative regulation of regulated secretory pathway(GO:1903306)
0.0 0.1 GO:0044406 virion attachment to host cell(GO:0019062) adhesion of symbiont to host(GO:0044406) adhesion of symbiont to host cell(GO:0044650)
0.0 0.5 GO:0034394 protein localization to cell surface(GO:0034394)
0.0 0.2 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 0.3 GO:1902306 negative regulation of sodium ion transmembrane transport(GO:1902306) negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.0 0.3 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.1 GO:0035046 pronuclear migration(GO:0035046)
0.0 0.1 GO:0045117 azole transport(GO:0045117)
0.0 0.2 GO:1900744 regulation of p38MAPK cascade(GO:1900744)
0.0 0.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.3 GO:0050975 sensory perception of touch(GO:0050975)
0.0 0.7 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.7 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.0 0.1 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0 0.3 GO:0060976 coronary vasculature development(GO:0060976)
0.0 0.1 GO:1990869 response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869) negative regulation of lymphocyte migration(GO:2000402) negative regulation of T cell migration(GO:2000405)
0.0 0.1 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.0 0.9 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 0.8 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.0 0.1 GO:0046184 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166) aldehyde biosynthetic process(GO:0046184)
0.0 0.8 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.0 0.1 GO:0090141 positive regulation of mitochondrial fission(GO:0090141)
0.0 0.5 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.5 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.0 0.4 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.1 GO:1905072 cardiac jelly development(GO:1905072)
0.0 0.2 GO:2000316 regulation of T-helper 17 type immune response(GO:2000316) negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320) regulation of T-helper 17 cell lineage commitment(GO:2000328) negative regulation of T-helper 17 cell lineage commitment(GO:2000329)
0.0 0.1 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.0 0.1 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.1 GO:0009191 ribonucleoside diphosphate catabolic process(GO:0009191)
0.0 0.2 GO:0048011 neurotrophin TRK receptor signaling pathway(GO:0048011)
0.0 0.1 GO:0051660 establishment of centrosome localization(GO:0051660)
0.0 0.3 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.0 0.1 GO:0071305 cellular response to vitamin D(GO:0071305)
0.0 0.3 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.2 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.3 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.1 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.0 0.2 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.3 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.0 0.1 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.0 0.2 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 0.4 GO:1902307 positive regulation of sodium ion transport(GO:0010765) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0 0.1 GO:0030328 prenylated protein catabolic process(GO:0030327) prenylcysteine catabolic process(GO:0030328) prenylcysteine metabolic process(GO:0030329)
0.0 0.3 GO:0006868 glutamine transport(GO:0006868)
0.0 1.6 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.1 GO:0070131 regulation of mitochondrial translation(GO:0070129) positive regulation of mitochondrial translation(GO:0070131)
0.0 1.2 GO:0007586 digestion(GO:0007586)
0.0 0.1 GO:0007414 axonal defasciculation(GO:0007414)
0.0 0.2 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.2 GO:0032228 regulation of synaptic transmission, GABAergic(GO:0032228)
0.0 0.9 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.3 GO:0035094 response to nicotine(GO:0035094)
0.0 0.1 GO:0003418 chondrocyte differentiation involved in endochondral bone morphogenesis(GO:0003413) growth plate cartilage chondrocyte differentiation(GO:0003418)
0.0 0.1 GO:0021519 optic cup formation involved in camera-type eye development(GO:0003408) spinal cord association neuron specification(GO:0021519)
0.0 0.8 GO:0072015 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 0.1 GO:0099563 modification of synaptic structure(GO:0099563)
0.0 0.1 GO:0002164 larval development(GO:0002164) larval heart development(GO:0007508)
0.0 0.1 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0 0.5 GO:0014823 response to activity(GO:0014823)
0.0 0.5 GO:0048168 regulation of neuronal synaptic plasticity(GO:0048168)
0.0 0.3 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.0 0.9 GO:0021587 cerebellum morphogenesis(GO:0021587)
0.0 0.3 GO:0030431 sleep(GO:0030431)
0.0 0.4 GO:0071436 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.0 0.1 GO:0072314 glomerular visceral epithelial cell fate commitment(GO:0072149) glomerular epithelial cell fate commitment(GO:0072314)
0.0 0.4 GO:0015671 oxygen transport(GO:0015671)
0.0 0.2 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.0 0.1 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.0 0.1 GO:0015990 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) electron transport coupled proton transport(GO:0015990)
0.0 0.1 GO:2000178 negative regulation of neural precursor cell proliferation(GO:2000178)
0.0 0.2 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.1 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.1 GO:0045724 positive regulation of cilium assembly(GO:0045724)
0.0 0.3 GO:0010996 response to auditory stimulus(GO:0010996)
0.0 0.1 GO:0006545 glycine biosynthetic process(GO:0006545)
0.0 0.3 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.0 0.2 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.1 GO:0002082 regulation of oxidative phosphorylation(GO:0002082)
0.0 0.8 GO:0060840 artery development(GO:0060840)
0.0 0.1 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.0 0.2 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.2 GO:0035188 hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0 0.2 GO:0090148 membrane fission(GO:0090148)
0.0 0.2 GO:0001964 startle response(GO:0001964)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.1 GO:0090243 fibroblast growth factor receptor signaling pathway involved in somitogenesis(GO:0090243)
0.0 0.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.1 GO:0044003 modification by symbiont of host morphology or physiology(GO:0044003) modulation by symbiont of host cellular process(GO:0044068)
0.0 0.2 GO:0043981 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.0 0.3 GO:0042551 neuron maturation(GO:0042551)
0.0 0.2 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.3 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.2 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.1 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.0 0.1 GO:0015860 intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
0.0 0.2 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.1 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.0 0.3 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.0 GO:1905048 regulation of metallopeptidase activity(GO:1905048)
0.0 0.1 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.0 0.1 GO:0045730 respiratory burst(GO:0045730)
0.0 0.1 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 0.3 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0034982 mitochondrial protein processing(GO:0034982)
0.0 0.1 GO:0070272 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0 0.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.1 GO:0043114 regulation of vascular permeability(GO:0043114)
0.0 2.6 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 0.1 GO:0051877 pigment granule aggregation in cell center(GO:0051877)
0.0 0.1 GO:0001919 regulation of receptor recycling(GO:0001919)
0.0 0.3 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 0.2 GO:0043550 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.6 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 1.0 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.2 GO:0042119 granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.0 1.2 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.1 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.1 GO:0016121 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.0 0.2 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.1 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 0.1 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.0 0.2 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.0 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.2 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.1 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 0.1 GO:0002063 chondrocyte development(GO:0002063)
0.0 0.2 GO:0033555 multicellular organismal response to stress(GO:0033555)
0.0 0.1 GO:2000479 regulation of cAMP-dependent protein kinase activity(GO:2000479)
0.0 0.1 GO:0071501 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.1 GO:0072576 liver morphogenesis(GO:0072576)
0.0 0.0 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 0.1 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.0 0.5 GO:0031638 zymogen activation(GO:0031638)
0.0 0.4 GO:0045739 positive regulation of DNA repair(GO:0045739)
0.0 0.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 0.7 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1 0.3 GO:0060077 inhibitory synapse(GO:0060077)
0.1 0.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 0.4 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 0.4 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 0.3 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 0.3 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.9 GO:0043209 myelin sheath(GO:0043209)
0.0 0.1 GO:0005592 collagen type XI trimer(GO:0005592)
0.0 0.2 GO:1990071 TRAPPII protein complex(GO:1990071)
0.0 0.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.0 0.2 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.2 GO:0097224 sperm connecting piece(GO:0097224)
0.0 0.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.3 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.7 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.0 0.1 GO:0070578 RISC-loading complex(GO:0070578)
0.0 0.2 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.2 GO:0001650 fibrillar center(GO:0001650)
0.0 0.1 GO:1904949 ATP-binding cassette (ABC) transporter complex(GO:0043190) ATPase dependent transmembrane transport complex(GO:0098533) ATPase complex(GO:1904949)
0.0 0.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.2 GO:0043204 perikaryon(GO:0043204)
0.0 0.2 GO:0071914 prominosome(GO:0071914)
0.0 0.5 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.1 GO:0060171 stereocilium membrane(GO:0060171)
0.0 0.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.5 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.4 GO:0043195 terminal bouton(GO:0043195)
0.0 1.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.1 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.0 0.1 GO:1902636 kinociliary basal body(GO:1902636)
0.0 0.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.3 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.1 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.5 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.9 GO:0014069 postsynaptic density(GO:0014069)
0.0 0.3 GO:0005579 membrane attack complex(GO:0005579)
0.0 1.1 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.1 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.0 2.5 GO:0030424 axon(GO:0030424)
0.0 0.1 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.3 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 0.3 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.5 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)
0.0 0.1 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.1 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 1.0 GO:0005795 Golgi stack(GO:0005795)
0.0 0.1 GO:0097431 mitotic spindle pole(GO:0097431)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.2 1.0 GO:0052656 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.2 0.5 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.2 0.5 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403) brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.1 0.5 GO:0016521 pituitary adenylate cyclase activating polypeptide activity(GO:0016521)
0.1 0.4 GO:0044548 S100 protein binding(GO:0044548)
0.1 0.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.0 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.1 0.6 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 0.3 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.1 0.6 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 0.6 GO:0016880 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.1 0.5 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.1 0.4 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.1 0.4 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429)
0.1 0.4 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.1 0.3 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.1 0.4 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.4 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.1 0.9 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.2 GO:0008517 folic acid transporter activity(GO:0008517)
0.1 0.4 GO:0098809 nitrite reductase activity(GO:0098809)
0.1 0.2 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.1 0.2 GO:0072591 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590) citrate-L-glutamate ligase activity(GO:0072591)
0.1 0.2 GO:0004779 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.1 0.5 GO:0030332 cyclin binding(GO:0030332)
0.1 0.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.1 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.0 0.2 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.0 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.0 0.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.5 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 1.0 GO:0008483 transaminase activity(GO:0008483)
0.0 0.2 GO:0004925 prolactin receptor activity(GO:0004925)
0.0 0.1 GO:0031704 apelin receptor binding(GO:0031704)
0.0 0.2 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0045118 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0 0.2 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.4 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.1 GO:0004133 glycogen debranching enzyme activity(GO:0004133) 4-alpha-glucanotransferase activity(GO:0004134) amylo-alpha-1,6-glucosidase activity(GO:0004135)
0.0 0.2 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.6 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.7 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.1 GO:0008929 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.0 0.2 GO:0016531 copper chaperone activity(GO:0016531)
0.0 0.2 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.6 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.3 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.3 GO:0005113 patched binding(GO:0005113)
0.0 0.4 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 0.1 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.0 0.2 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.5 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.1 GO:0070738 protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
0.0 0.2 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.4 GO:0019870 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.0 0.1 GO:0001735 prenylcysteine oxidase activity(GO:0001735)
0.0 0.2 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.1 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296) pre-miRNA binding(GO:0070883)
0.0 0.1 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.2 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.4 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.3 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.0 0.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.2 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.4 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.1 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.1 GO:0043621 protein self-association(GO:0043621)
0.0 0.1 GO:0004960 thromboxane receptor activity(GO:0004960)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.3 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.0 0.4 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.2 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.2 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.4 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.1 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
0.0 0.1 GO:0043531 ADP binding(GO:0043531)
0.0 0.3 GO:0098988 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.0 0.1 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 0.1 GO:0004361 glutaryl-CoA dehydrogenase activity(GO:0004361)
0.0 0.3 GO:0048018 receptor activator activity(GO:0030546) receptor agonist activity(GO:0048018)
0.0 0.4 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.3 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.2 GO:0031994 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:2001070 starch binding(GO:2001070)
0.0 0.3 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:1903924 estradiol binding(GO:1903924)
0.0 0.6 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.3 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.1 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.1 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.0 0.2 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.1 GO:0004743 pyruvate kinase activity(GO:0004743)
0.0 0.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 0.8 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.2 GO:0030552 cAMP binding(GO:0030552)
0.0 0.5 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.0 0.1 GO:0005471 ATP:ADP antiporter activity(GO:0005471)
0.0 0.1 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.8 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0004997 thyrotropin-releasing hormone receptor activity(GO:0004997)
0.0 0.2 GO:0005158 insulin receptor binding(GO:0005158)
0.0 1.9 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 0.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.3 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.2 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.2 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.1 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.3 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.1 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.3 GO:0010181 FMN binding(GO:0010181)
0.0 0.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.1 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.2 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.1 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 0.5 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0003834 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.0 0.6 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.6 GO:0005178 integrin binding(GO:0005178)
0.0 0.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.2 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.1 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.1 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.1 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.0 GO:0008117 sphinganine-1-phosphate aldolase activity(GO:0008117)
0.0 0.1 GO:0015232 heme transporter activity(GO:0015232)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.4 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.6 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.8 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.3 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.1 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.6 PID SHP2 PATHWAY SHP2 signaling
0.0 1.0 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.6 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.2 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.5 PID INSULIN PATHWAY Insulin Pathway
0.0 0.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.1 PID MYC PATHWAY C-MYC pathway
0.0 0.2 PID WNT SIGNALING PATHWAY Wnt signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.5 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0 0.6 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.8 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.6 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.3 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.2 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.5 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 1.3 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.3 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.6 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.3 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.3 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.6 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.2 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.4 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.1 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.2 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.2 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.3 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 0.5 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.2 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.4 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.3 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.2 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.2 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.1 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.2 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.3 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.3 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.1 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.1 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism