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PRJNA207719: Tissue specific transcriptome profiling
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Results for esr1+esr2a+esr2b
Z-value: 1.42
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Transcription factors associated with esr1+esr2a+esr2b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| esr2a | dr11_v1_chr20_+_21583639_21583639 | 0.70 | 1.8e-01 | Click! |
| esr2b | dr11_v1_chr13_+_37022601_37022632 | 0.54 | 3.5e-01 | Click! |
| esr1 | dr11_v1_chr20_-_26382284_26382284 | 0.51 | 3.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_1317290 Show fit | 1.05 |
ENSDART00000047094
|
|
|
| chr12_+_7491690 Show fit | 1.04 |
ENSDART00000152564
|
phytanoyl-CoA 2-hydroxylase interacting protein-like b |
|
| chr4_+_17280868 Show fit | 1.01 |
ENSDART00000145349
|
branched chain amino-acid transaminase 1, cytosolic |
|
| chr1_-_59176949 Show fit | 0.99 |
ENSDART00000128742
|
|
|
| chr17_-_6738538 Show fit | 0.94 |
ENSDART00000157125
|
visinin-like 1b |
|
| chr24_-_38374744 Show fit | 0.90 |
ENSDART00000007208
|
leucine rich repeat containing 4Bb |
|
| chr5_-_23280098 Show fit | 0.89 |
ENSDART00000126540
ENSDART00000051533 |
proteolipid protein 1b |
|
| chr20_+_5564042 Show fit | 0.84 |
ENSDART00000090934
ENSDART00000127050 |
neurexin 3b |
|
| chr5_-_55395964 Show fit | 0.83 |
ENSDART00000145791
|
prune homolog 2 (Drosophila) |
|
| chr25_-_19374710 Show fit | 0.80 |
ENSDART00000184483
ENSDART00000188706 |
microtubule-associated protein 1Ab |
Network of associatons between targets according to the STRING database.
First level regulatory network of esr1+esr2a+esr2b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | GO:0071804 | cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805) |
| 0.0 | 1.6 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.1 | 1.3 | GO:0031114 | regulation of microtubule depolymerization(GO:0031114) |
| 0.0 | 1.2 | GO:0007586 | digestion(GO:0007586) |
| 0.0 | 1.2 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.3 | 1.1 | GO:0015803 | branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820) |
| 0.1 | 1.1 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
| 0.1 | 1.1 | GO:0022010 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
| 0.2 | 1.0 | GO:0009098 | leucine biosynthetic process(GO:0009098) |
| 0.1 | 1.0 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | GO:0030424 | axon(GO:0030424) |
| 0.0 | 1.9 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.0 | 1.3 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 1.2 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 1.1 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.0 | 1.0 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.0 | 0.9 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 0.8 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 0.7 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.0 | 0.7 | GO:0098844 | postsynaptic endocytic zone membrane(GO:0098844) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.0 | 1.6 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.3 | 1.0 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.2 | 1.0 | GO:0052656 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
| 0.1 | 1.0 | GO:0004309 | exopolyphosphatase activity(GO:0004309) |
| 0.0 | 1.0 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.1 | 0.9 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.1 | 0.9 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.1 | 0.9 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.0 | 0.9 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.8 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.6 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.0 | 0.6 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 0.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.5 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.5 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 0.4 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 0.4 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.8 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.6 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 0.6 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.0 | 0.6 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.6 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 0.5 | REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors |
| 0.0 | 0.5 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 0.5 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.5 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |