PRJNA207719: Tissue specific transcriptome profiling


Results for eomesa

Z-value: 1.44

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Transcription factors associated with eomesa

Gene Symbol Gene ID Gene Info
ENSDARG00000006640 eomesodermin homolog a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of eomesa motif

Sorted Z-values of eomesa motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_21877726 1.11 ENSDART00000127819
chr2_-_32637592 1.09 ENSDART00000136353
chr10_+_19596214 0.83 ENSDART00000183110

chr7_+_27691647 0.77 ENSDART00000079091
cytochrome P450, family 2, subfamily R, polypeptide 1
chr16_+_23947196 0.73 ENSDART00000103190
apolipoprotein A-IV b, tandem duplicate 2
chr22_+_25352530 0.72 ENSDART00000176742
chr22_+_25693295 0.72 ENSDART00000123888
chr22_+_25715925 0.70 ENSDART00000150650
chr20_-_40755614 0.70 ENSDART00000061247
connexin 32.3
chr22_+_25687525 0.69 ENSDART00000135717
chr22_+_25681911 0.69 ENSDART00000113381
chr22_+_25704430 0.67 ENSDART00000143776
chr21_-_1742159 0.66 ENSDART00000151049
one cut homeobox 2
chr23_-_31647793 0.66 ENSDART00000145621
serum/glucocorticoid regulated kinase 1
chr23_-_31648026 0.64 ENSDART00000133569
serum/glucocorticoid regulated kinase 1
chr1_+_29741843 0.64 ENSDART00000136066
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1b
chr11_-_40504170 0.64 ENSDART00000165394
chr10_+_19595009 0.57 ENSDART00000112276
chr19_-_27564458 0.51 ENSDART00000123155
chr10_-_25217347 0.51 ENSDART00000036906
karyopherin alpha 7 (importin alpha 8)
chr22_+_25753972 0.50 ENSDART00000188417

chr16_+_44314097 0.48 ENSDART00000148684
chr13_-_9318891 0.48 ENSDART00000137364
chr17_+_36588281 0.43 ENSDART00000076115
5-hydroxytryptamine (serotonin) receptor 1B
chr3_+_59051503 0.42 ENSDART00000160767
rasd family member 4
chr1_+_45323142 0.42 ENSDART00000132210
epithelial membrane protein 1
chr25_-_13703826 0.41 ENSDART00000163398
phospholipase A2, group XV
chr13_-_51952020 0.34 ENSDART00000181079

chr11_-_1550709 0.32 ENSDART00000110097
chr25_+_24250247 0.32 ENSDART00000064646
transmembrane protein 86A
chr14_-_2361692 0.31 ENSDART00000167696
chr7_+_73332486 0.31 ENSDART00000174119

chr22_+_25274712 0.28 ENSDART00000137341

chr5_+_31036911 0.28 ENSDART00000141463
zinc finger, ZZ-type with EF hand domain 1
chr10_-_5847904 0.27 ENSDART00000161096
ankyrin repeat domain 55
chr5_+_62319217 0.26 ENSDART00000050879
chr22_-_36690742 0.26 ENSDART00000017188
chr9_-_12885201 0.26 ENSDART00000124957
ankyrin repeat and zinc finger domain containing 1
chr3_+_16449490 0.25 ENSDART00000141467
potassium inwardly-rectifying channel, subfamily J, member 12b
chr1_-_45042210 0.25 ENSDART00000073694
SMU1, DNA replication regulator and spliceosomal factor b
chr10_-_28193642 0.25 ENSDART00000019050
ribosomal protein S6 kinase b, polypeptide 1a
chr10_+_35953068 0.25 ENSDART00000015279
reticulon 4 receptor-like 1a
chr2_-_57469115 0.24 ENSDART00000192201
protein inhibitor of activated STAT, 4b
chr10_-_5847655 0.24 ENSDART00000192773
ankyrin repeat domain 55
chr1_+_45323400 0.24 ENSDART00000148906
epithelial membrane protein 1
chr7_+_23907692 0.23 ENSDART00000045479
synaptotagmin IV
chr22_-_5252005 0.23 ENSDART00000132942
chr16_+_14812585 0.23 ENSDART00000134087
collagen, type XIV, alpha 1a
chr18_+_6641542 0.23 ENSDART00000160379
C2 calcium-dependent domain containing 5
chr19_-_867071 0.23 ENSDART00000122257
eomesodermin homolog a
chr2_-_13216269 0.22 ENSDART00000149947
BCL2, apoptosis regulator b
chr20_-_46773258 0.21 ENSDART00000060653
chr5_+_32007627 0.21 ENSDART00000183061
suppressor of cancer cell invasion
chr22_+_19111444 0.21 ENSDART00000109655
fibroblast growth factor 22
chr22_-_6066867 0.21 ENSDART00000142383
chr13_-_280827 0.21 ENSDART00000144819
solute carrier family 30 (zinc transporter), member 6
chr5_-_45877387 0.20 ENSDART00000183714
solute carrier family 4 (sodium bicarbonate cotransporter), member 4a
chr2_-_34555945 0.19 ENSDART00000056671
bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr12_-_48960308 0.17 ENSDART00000176247

chr23_+_4362463 0.16 ENSDART00000039829
chr1_+_5576151 0.16 ENSDART00000109756
carboxypeptidase O
chr6_+_54538948 0.16 ENSDART00000149270
tubby like protein 1b
chr11_+_14622379 0.15 ENSDART00000112589
chr14_-_2602445 0.14 ENSDART00000166910
eukaryotic translation termination factor 1a
chr15_-_35112937 0.13 ENSDART00000154565
chr25_-_17367578 0.12 ENSDART00000064591
cytochrome P450, family 2, subfamily X, polypeptide 6
chr11_-_40728380 0.12 ENSDART00000023745
coiled-coil domain containing 114
chr3_-_60827402 0.12 ENSDART00000053494
ankyrin repeat and sterile alpha motif domain containing 4B
chr20_-_32007209 0.12 ENSDART00000021575
chr1_+_57142509 0.11 ENSDART00000146799
chr22_+_26263290 0.11 ENSDART00000184840

chr1_-_55750208 0.10 ENSDART00000142244
DnaJ (Hsp40) homolog, subfamily B, member 1b
chr21_-_27010796 0.10 ENSDART00000065398
protein phosphatase 1, regulatory (inhibitor) subunit 14Ba
chr24_-_24060460 0.10 ENSDART00000142813
ATP-binding cassette, sub-family C (CFTR/MRP), member 13
chr18_+_33779440 0.09 ENSDART00000133349
chr10_+_26612321 0.09 ENSDART00000134322
four and a half LIM domains 1b
chr8_+_45003659 0.09 ENSDART00000132663
chr7_+_9981757 0.09 ENSDART00000113429
ADAM metallopeptidase with thrombospondin type 1 motif, 17
chr7_+_21275152 0.09 ENSDART00000173612
serine (or cysteine) peptidase inhibitor, clade H, member 2
chr5_-_67762434 0.09 ENSDART00000167301
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
chr2_+_42177113 0.09 ENSDART00000056441
transmembrane protein with EGF-like and two follistatin-like domains 1a
chr10_-_8956973 0.09 ENSDART00000189564
molybdenum cofactor synthesis 2
chr1_-_57129179 0.09 ENSDART00000157226
chr19_+_2275019 0.09 ENSDART00000136138
integrin, beta 8
chr7_-_69983462 0.09 ENSDART00000123380
potassium voltage-gated channel interacting protein 4
chr17_-_29312506 0.07 ENSDART00000133668
tectonin beta-propeller repeat containing 2
chr15_+_28940352 0.07 ENSDART00000154085
gastric inhibitory polypeptide receptor
chr11_-_13341051 0.07 ENSDART00000121872
microtubule associated serine/threonine kinase 3b
chr4_-_77624155 0.07 ENSDART00000099761
chr2_+_35240485 0.07 ENSDART00000179804
tenascin R (restrictin, janusin)
chr15_-_45538773 0.06 ENSDART00000113494
Mab-21 domain containing 2
chr4_-_51460013 0.06 ENSDART00000193382

chr18_-_20444296 0.06 ENSDART00000132993
kinesin family member 23
chr10_-_9115383 0.06 ENSDART00000139324
chr20_-_35052464 0.06 ENSDART00000037195
kinesin family member 26Bb
chr22_-_14475927 0.06 ENSDART00000135768
low density lipoprotein receptor-related protein 1Ba
chr12_+_5129245 0.05 ENSDART00000169073
phosphodiesterase 6C, cGMP-specific, cone, alpha prime
chr2_-_10896745 0.05 ENSDART00000114609
CUB domain containing protein 2
chr22_+_25774750 0.05 ENSDART00000174421

chr5_-_41645058 0.05 ENSDART00000051092
RIO kinase 2 (yeast)
chr4_-_72555545 0.05 ENSDART00000172315
chr12_-_10421955 0.04 ENSDART00000052004
chr22_-_9896180 0.04 ENSDART00000138343
zinc finger protein 990
chr7_+_30493684 0.04 ENSDART00000027466
MINDY lysine 48 deubiquitinase 2
chr22_+_10010292 0.04 ENSDART00000180096

chr10_+_16092671 0.04 ENSDART00000182761
multiple EGF-like-domains 10
chr7_-_1101694 0.04 ENSDART00000183017
dynactin 1a
chr8_+_25267903 0.04 ENSDART00000093090
adenosine monophosphate deaminase 2b
chr24_-_36196077 0.03 ENSDART00000154395
establishment of sister chromatid cohesion N-acetyltransferase 1
chr5_-_16475374 0.03 ENSDART00000134274
piwi-like RNA-mediated gene silencing 2
chr22_-_18544701 0.03 ENSDART00000132156
cold inducible RNA binding protein b
chr25_+_32071558 0.03 ENSDART00000155992
tight junction protein 1b
chr9_-_23824290 0.02 ENSDART00000059209
WD repeat and FYVE domain containing 2
chr7_-_61845282 0.02 ENSDART00000182586
HtrA serine peptidase 3
chr5_+_45000597 0.02 ENSDART00000051146
doublesex and mab-3 related transcription factor 3a
chr21_-_14815952 0.01 ENSDART00000134278
phosphohistidine phosphatase 1
chr25_-_23583101 0.01 ENSDART00000149107
nucleosome assembly protein 1-like 4a
chr15_-_35126632 0.01 ENSDART00000187324
chr3_+_37083765 0.00 ENSDART00000125611
reticulophagy regulator family member 3

Network of associatons between targets according to the STRING database.

First level regulatory network of eomesa

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0010873 regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873)
0.1 0.8 GO:0071305 vitamin D3 metabolic process(GO:0070640) cellular response to vitamin D(GO:0071305)
0.1 0.2 GO:0055109 invagination involved in gastrulation with mouth forming second(GO:0055109) morphogenesis of an epithelial fold(GO:0060571)
0.0 0.2 GO:0038107 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.0 0.2 GO:0010828 positive regulation of glucose transport(GO:0010828)
0.0 0.5 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.2 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.0 0.1 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.0 0.5 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.0 0.4 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 0.3 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.2 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.5 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.3 GO:1990399 sensory epithelium regeneration(GO:0070654) epithelium regeneration(GO:1990399)
0.0 0.1 GO:1990798 pancreas regeneration(GO:1990798)
0.0 0.0 GO:0034421 post-translational protein acetylation(GO:0034421)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0042627 chylomicron(GO:0042627)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0018444 translation release factor complex(GO:0018444)
0.0 0.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.1 GO:0019008 molybdopterin synthase complex(GO:0019008)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0 0.1 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.5 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.3 GO:0016803 ether hydrolase activity(GO:0016803)
0.0 1.3 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.5 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.0 0.4 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.2 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.2 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 4.7 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.1 GO:0030366 molybdopterin synthase activity(GO:0030366)
0.0 0.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0016519 gastric inhibitory peptide receptor activity(GO:0016519)
0.0 0.9 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.4 GO:0019003 GDP binding(GO:0019003)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID FOXO PATHWAY FoxO family signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.1 0.5 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.8 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.2 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation