ISMARA results: en1b_en2a+en2b_gbx1

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PRJNA207719: Tissue specific transcriptome profiling

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Results for en1b_en2a+en2b_gbx1_emx1

Z-value: 1.14

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Transcription factors associated with en1b_en2a+en2b_gbx1_emx1

Gene Symbol	Gene ID	Gene Info
en1b NCBI UniProt	ENSDARG00000098730	engrailed homeobox 1b
en2a NCBI UniProt	ENSDARG00000026599	engrailed homeobox 2a
en2b NCBI UniProt	ENSDARG00000038868	engrailed homeobox 2b
en2a NCBI UniProt	ENSDARG00000115233	engrailed homeobox 2a
gbx1 NCBI UniProt	ENSDARG00000071418	gastrulation brain homeobox 1
emx1 NCBI UniProt	ENSDARG00000039569	empty spiracles homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
en2a	dr11_v1_chr7_-_40993456_40993456	0.99	5.9e-04	Click!
en2b	dr11_v1_chr2_+_29976419_29976419	0.99	1.3e-03	Click!
en1b	dr11_v1_chr1_+_7679328_7679328	0.97	6.3e-03	Click!
emx1	dr11_v1_chr13_+_15004398_15004398	0.95	1.3e-02	Click!
gbx1	dr11_v1_chr24_+_34113424_34113424	0.88	5.2e-02	Click!

Activity profile of en1b_en2a+en2b_gbx1_emx1 motif

Sorted Z-values of en1b_en2a+en2b_gbx1_emx1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_+_64732036 Show fit	2.10	ENSDART00000073950	olfm1a NCBI UniProt Show fit	olfactomedin 1a
chr5_+_64732270 Show fit	2.04	ENSDART00000134241	olfm1a NCBI UniProt Show fit	olfactomedin 1a
chr6_+_39232245 Show fit	1.79	ENSDART00000187351	b4galnt1b NCBI UniProt Show fit	beta-1,4-N-acetyl-galactosaminyl transferase 1b
chr11_-_42554290 Show fit	1.66	ENSDART00000130573	atp6ap1la NCBI UniProt Show fit	ATPase H+ transporting accessory protein 1 like a
chr23_+_40460333 Show fit	1.65	ENSDART00000184658	soga3b NCBI UniProt Show fit	SOGA family member 3b
chr19_+_5543072 Show fit	1.57	ENSDART00000082080	jupb NCBI UniProt Show fit	junction plakoglobin b
chr23_+_44741500 Show fit	1.53	ENSDART00000166421	atp1b2a NCBI UniProt Show fit	ATPase Na+/K+ transporting subunit beta 2a
chr7_+_30787903 Show fit	1.48	ENSDART00000174000	apba2b NCBI UniProt Show fit	amyloid beta (A4) precursor protein-binding, family A, member 2b
chr2_+_50608099 Show fit	1.47	ENSDART00000185805 ENSDART00000111135	neurod6b NCBI UniProt Show fit	neuronal differentiation 6b
chr7_+_13418812 Show fit	1.39	ENSDART00000191905 ENSDART00000091567	dagla NCBI UniProt Show fit	diacylglycerol lipase, alpha

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of en1b_en2a+en2b_gbx1_emx1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	4.1	GO:0061075	positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
0.0	2.2	GO:1902600	hydrogen ion transmembrane transport(GO:1902600)
0.0	1.9	GO:0070588	calcium ion transmembrane transport(GO:0070588)
0.1	1.8	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	1.8	GO:0046513	ceramide biosynthetic process(GO:0046513)
0.3	1.6	GO:0002159	desmosome assembly(GO:0002159)
0.0	1.6	GO:0010506	regulation of autophagy(GO:0010506)
0.2	1.5	GO:1904071	presynaptic active zone assembly(GO:1904071)
0.1	1.5	GO:0071436	cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.0	1.5	GO:0035249	synaptic transmission, glutamatergic(GO:0035249)

Showing 1 to 10 of 185 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.2	GO:0045202	synapse(GO:0045202)
0.0	3.9	GO:0008021	synaptic vesicle(GO:0008021)
0.0	2.7	GO:0030424	axon(GO:0030424)
0.0	2.4	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	2.0	GO:0005905	clathrin-coated pit(GO:0005905)
0.3	1.7	GO:0033181	plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.1	1.7	GO:0031209	SCAR complex(GO:0031209)
0.2	1.5	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.2	1.5	GO:0098982	GABA-ergic synapse(GO:0098982)
0.1	1.4	GO:0032591	dendritic spine membrane(GO:0032591)

Showing 1 to 10 of 65 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.1	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.1	2.1	GO:0017075	syntaxin-1 binding(GO:0017075)
0.1	2.0	GO:0001540	beta-amyloid binding(GO:0001540)
0.1	1.8	GO:0050291	sphingosine N-acyltransferase activity(GO:0050291)
0.0	1.8	GO:0008376	acetylgalactosaminyltransferase activity(GO:0008376)
0.2	1.6	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	1.6	GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0	1.6	GO:0030215	semaphorin receptor binding(GO:0030215)
0.1	1.5	GO:0098882	structural constituent of presynaptic active zone(GO:0098882)
0.1	1.4	GO:0001671	ATPase activator activity(GO:0001671)

Showing 1 to 10 of 118 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.6	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.1	1.4	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	1.0	PID REELIN PATHWAY	Reelin signaling pathway
0.0	1.0	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	1.0	PID MTOR 4PATHWAY	mTOR signaling pathway
0.0	0.9	PID RAS PATHWAY	Regulation of Ras family activation
0.0	0.9	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	0.8	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	0.8	PID RAC1 PATHWAY	RAC1 signaling pathway
0.1	0.7	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway

Showing 1 to 10 of 17 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.9	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.1	1.7	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.1	1.5	REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	Genes involved in Nitric oxide stimulates guanylate cyclase
0.1	1.2	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.2	1.1	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1	1.0	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.1	0.9	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.1	0.9	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.8	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.0	0.5	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)

Showing 1 to 10 of 26 entries

Results for en1b_en2a+en2b_gbx1_emx1

Z-value: 1.14

Motif logo

Transcription factors associated with en1b_en2a+en2b_gbx1_emx1

Activity-expression correlation:

Activity profile of en1b_en2a+en2b_gbx1_emx1 motif

Sorted Z-values of en1b_en2a+en2b_gbx1_emx1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of en1b_en2a+en2b_gbx1_emx1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: