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PRJNA207719: Tissue specific transcriptome profiling
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Results for emx2+emx3
Z-value: 0.99
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Transcription factors associated with emx2+emx3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| emx2 | dr11_v1_chr13_+_19322686_19322686 | -0.90 | 3.9e-02 | Click! |
| emx3 | dr11_v1_chr14_-_26377044_26377044 | -0.75 | 1.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_2815021 Show fit | 0.91 |
ENSDART00000020472
|
4-hydroxyphenylpyruvate dioxygenase a |
|
| chr5_+_35458190 Show fit | 0.90 |
ENSDART00000051313
|
fructose-1,6-bisphosphatase 1b |
|
| chr4_+_25654686 Show fit | 0.78 |
ENSDART00000100714
|
acyl-CoA thioesterase 16 |
|
| chr2_+_41926707 Show fit | 0.71 |
ENSDART00000023208
|
zgc:110183 |
|
| chr20_-_40755614 Show fit | 0.61 |
ENSDART00000061247
|
connexin 32.3 |
|
| chr6_+_49926115 Show fit | 0.60 |
ENSDART00000018523
|
adenosylhomocysteinase |
|
| chr20_+_54309148 Show fit | 0.55 |
ENSDART00000099360
|
zona pellucida glycoprotein 2, tandem duplicate 1 |
|
| chr25_+_22320738 Show fit | 0.54 |
ENSDART00000073566
|
cytochrome P450, family 11, subfamily A, polypeptide 1 |
|
| chr1_-_18811517 Show fit | 0.54 |
ENSDART00000142026
|
si:dkey-167i21.2 |
|
| chr8_-_23780334 Show fit | 0.54 |
ENSDART00000145179
ENSDART00000145894 |
zgc:195245 |
Network of associatons between targets according to the STRING database.
First level regulatory network of emx2+emx3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0071222 | cellular response to molecule of bacterial origin(GO:0071219) cellular response to lipopolysaccharide(GO:0071222) |
| 0.3 | 0.9 | GO:0005985 | sucrose metabolic process(GO:0005985) sucrose biosynthetic process(GO:0005986) disaccharide biosynthetic process(GO:0046351) |
| 0.2 | 0.9 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
| 0.2 | 0.9 | GO:0060967 | negative regulation of posttranscriptional gene silencing(GO:0060149) negative regulation of gene silencing by miRNA(GO:0060965) negative regulation of gene silencing by RNA(GO:0060967) |
| 0.0 | 0.7 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.1 | 0.6 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.1 | 0.5 | GO:0006700 | C21-steroid hormone biosynthetic process(GO:0006700) |
| 0.0 | 0.5 | GO:0050727 | regulation of inflammatory response(GO:0050727) |
| 0.1 | 0.4 | GO:0006526 | arginine biosynthetic process(GO:0006526) |
| 0.1 | 0.4 | GO:0072512 | ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 0.4 | GO:0043540 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540) |
| 0.1 | 0.3 | GO:0031429 | box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) |
| 0.0 | 0.3 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 0.3 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.0 | 0.3 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 0.3 | GO:0032040 | small-subunit processome(GO:0032040) |
| 0.1 | 0.2 | GO:1990604 | IRE1-TRAF2-ASK1 complex(GO:1990604) |
| 0.1 | 0.2 | GO:0097124 | cyclin A2-CDK2 complex(GO:0097124) |
| 0.1 | 0.2 | GO:0030689 | Noc complex(GO:0030689) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.3 | 0.9 | GO:0003868 | 4-hydroxyphenylpyruvate dioxygenase activity(GO:0003868) |
| 0.3 | 0.9 | GO:0042132 | fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132) |
| 0.1 | 0.9 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.0 | 0.8 | GO:0047617 | acyl-CoA hydrolase activity(GO:0047617) |
| 0.2 | 0.6 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.0 | 0.6 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.2 | 0.5 | GO:0008386 | cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713) |
| 0.1 | 0.5 | GO:0008118 | N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118) |
| 0.0 | 0.5 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.5 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.3 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 0.2 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.1 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.1 | PID ALK2 PATHWAY | ALK2 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.1 | 0.5 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 0.0 | 0.5 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 0.4 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.0 | 0.4 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 0.4 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.2 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 0.2 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.2 | REACTOME FGFR LIGAND BINDING AND ACTIVATION | Genes involved in FGFR ligand binding and activation |
| 0.0 | 0.2 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |