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PRJNA207719: Tissue specific transcriptome profiling
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Results for egr4
Z-value: 0.83
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Transcription factors associated with egr4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| egr4 | dr11_v1_chr23_+_45579497_45579497 | -0.33 | 5.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_44963154 Show fit | 1.02 |
ENSDART00000073735
|
Ras-related associated with diabetes |
|
| chr24_+_24831727 Show fit | 0.89 |
ENSDART00000080969
|
tripartite motif containing 55b |
|
| chr25_+_30298377 Show fit | 0.80 |
ENSDART00000153622
|
chromosome 11 open reading frame 96 |
|
| chr2_-_48753873 Show fit | 0.76 |
ENSDART00000189556
|
|
|
| chr17_+_15297398 Show fit | 0.56 |
ENSDART00000156574
|
si:ch211-270g19.5 |
|
| chr1_-_47431453 Show fit | 0.47 |
ENSDART00000101104
|
gap junction protein, alpha 5b |
|
| chr17_-_10025234 Show fit | 0.41 |
ENSDART00000008355
|
cofilin 2 (muscle) |
|
| chr22_-_16180849 Show fit | 0.40 |
ENSDART00000090390
|
vascular cell adhesion molecule 1b |
|
| chr19_+_390298 Show fit | 0.32 |
ENSDART00000136361
|
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D |
|
| chr2_+_35880600 Show fit | 0.31 |
ENSDART00000004277
|
laminin, gamma 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of egr4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.0 | GO:1901842 | regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842) |
| 0.0 | 0.6 | GO:0043462 | regulation of ATPase activity(GO:0043462) |
| 0.0 | 0.5 | GO:0030534 | adult behavior(GO:0030534) |
| 0.1 | 0.4 | GO:0030043 | actin filament fragmentation(GO:0030043) |
| 0.0 | 0.3 | GO:0097107 | postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463) |
| 0.0 | 0.3 | GO:0050962 | detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) |
| 0.0 | 0.3 | GO:0006516 | glycoprotein catabolic process(GO:0006516) |
| 0.0 | 0.2 | GO:0070650 | actin filament bundle distribution(GO:0070650) |
| 0.0 | 0.2 | GO:0006552 | leucine catabolic process(GO:0006552) |
| 0.0 | 0.1 | GO:1904357 | negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 0.5 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 0.1 | GO:1990879 | CST complex(GO:1990879) |
| 0.0 | 0.1 | GO:1902636 | kinociliary basal body(GO:1902636) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.1 | 0.6 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.1 | 0.5 | GO:0055077 | gap junction hemi-channel activity(GO:0055077) |
| 0.1 | 0.3 | GO:0004373 | glycogen (starch) synthase activity(GO:0004373) |
| 0.0 | 0.3 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.1 | 0.2 | GO:0004485 | methylcrotonoyl-CoA carboxylase activity(GO:0004485) |
| 0.0 | 0.1 | GO:0031956 | medium-chain fatty acid-CoA ligase activity(GO:0031956) butyrate-CoA ligase activity(GO:0047760) |
| 0.0 | 0.1 | GO:0004082 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) |
| 0.0 | 0.1 | GO:0010521 | telomerase inhibitor activity(GO:0010521) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.3 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.3 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.3 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 0.2 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |