ISMARA results: egr3

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PRJNA207719: Tissue specific transcriptome profiling

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Results for egr3

Z-value: 0.75

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Transcription factors associated with egr3

Gene Symbol	Gene ID	Gene Info
egr3 NCBI UniProt	ENSDARG00000089156	early growth response 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
egr3	dr11_v1_chr8_+_50727220_50727220	-0.33	5.9e-01	Click!

Activity profile of egr3 motif

Sorted Z-values of egr3 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_+_56422311 Show fit	0.61	ENSDART00000171958	gpr39 NCBI UniProt Show fit	G protein-coupled receptor 39
chr17_-_2584423 Show fit	0.60	ENSDART00000013506	zp3.2 NCBI UniProt Show fit	zona pellucida glycoprotein 3, tandem duplicate 2
chr9_+_56422517 Show fit	0.52	ENSDART00000168620	gpr39 NCBI UniProt Show fit	G protein-coupled receptor 39
chr23_-_29556844 Show fit	0.37	ENSDART00000138021	rbp7a NCBI UniProt Show fit	retinol binding protein 7a, cellular
chr7_+_46019780 Show fit	0.35	ENSDART00000163991	ccne1 NCBI UniProt Show fit	cyclin E1
chr15_+_9294620 Show fit	0.34	ENSDART00000133588 ENSDART00000140009	slc37a4a NCBI UniProt Show fit	solute carrier family 37 (glucose-6-phosphate transporter), member 4a
chr8_+_6576940 Show fit	0.33	ENSDART00000138135	vsig8b NCBI UniProt Show fit	V-set and immunoglobulin domain containing 8b
chr14_+_29769336 Show fit	0.31	ENSDART00000105898	si:dkey-34l15.1 NCBI UniProt Show fit	si:dkey-34l15.1
chr22_-_10591876 Show fit	0.31	ENSDART00000105846	si:dkey-42i9.8 NCBI UniProt Show fit	si:dkey-42i9.8
chr7_-_46019756 Show fit	0.26	ENSDART00000162583	zgc:162297 NCBI UniProt Show fit	zgc:162297

Showing 1 to 10 of 71 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of egr3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.6	GO:0007339	binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.0	0.4	GO:0060972	left/right pattern formation(GO:0060972)
0.1	0.3	GO:1990359	detoxification of zinc ion(GO:0010312) stress response to zinc ion(GO:1990359)
0.0	0.2	GO:0006621	protein retention in ER lumen(GO:0006621)
0.0	0.2	GO:0071322	cellular response to carbohydrate stimulus(GO:0071322) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.0	0.2	GO:0050892	intestinal absorption(GO:0050892)
0.0	0.2	GO:0000076	DNA replication checkpoint(GO:0000076)

Showing 1 to 7 of 7 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0097134	cyclin E1-CDK2 complex(GO:0097134)
0.0	0.2	GO:0001669	acrosomal vesicle(GO:0001669)
0.0	0.2	GO:0030663	COPI-coated vesicle membrane(GO:0030663)
0.0	0.2	GO:0031680	G-protein beta/gamma-subunit complex(GO:0031680)

Showing 1 to 4 of 4 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0035804	structural constituent of egg coat(GO:0035804)
0.1	0.2	GO:0046923	ER retention sequence binding(GO:0046923)
0.1	0.2	GO:0008761	UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761) N-acylmannosamine kinase activity(GO:0009384)
0.0	0.2	GO:0070182	DNA polymerase binding(GO:0070182)
0.0	0.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.2	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.2	GO:0004679	AMP-activated protein kinase activity(GO:0004679)
0.0	0.1	GO:0031956	medium-chain fatty acid-CoA ligase activity(GO:0031956) butyrate-CoA ligase activity(GO:0047760)

Showing 1 to 8 of 8 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Showing 1 to 1 of 1 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.5	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.0	0.2	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline

Showing 1 to 2 of 2 entries

Results for egr3

Z-value: 0.75

Motif logo

Transcription factors associated with egr3

Activity-expression correlation:

Activity profile of egr3 motif

Sorted Z-values of egr3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of egr3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: