ISMARA results: egr2a+egr2b

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PRJNA207719: Tissue specific transcriptome profiling

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Results for egr2a+egr2b

Z-value: 1.78

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Transcription factors associated with egr2a+egr2b

Gene Symbol	Gene ID	Gene Info
egr2b NCBI UniProt	ENSDARG00000042826	early growth response 2b
egr2a NCBI UniProt	ENSDARG00000044098	early growth response 2a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
egr2b	dr11_v1_chr12_-_8486330_8486330	0.77	1.3e-01	Click!
egr2a	dr11_v1_chr17_-_43665366_43665366	0.48	4.1e-01	Click!

Activity profile of egr2a+egr2b motif

Sorted Z-values of egr2a+egr2b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_22535 Show fit	3.19	ENSDART00000157877	CABZ01092282.1 NCBI UniProt Show fit
chr20_-_54462551 Show fit	2.36	ENSDART00000171769 ENSDART00000169692	evlb NCBI UniProt Show fit	Enah/Vasp-like b
chr19_+_342094 Show fit	1.45	ENSDART00000151013 ENSDART00000187622	ensaa NCBI UniProt Show fit	endosulfine alpha a
chr12_+_18606140 Show fit	1.34	ENSDART00000161128	grid2ipb NCBI UniProt Show fit	glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein, b
chr23_-_637347 Show fit	1.23	ENSDART00000132175	l1camb NCBI UniProt Show fit	L1 cell adhesion molecule, paralog b
chr21_-_43949208 Show fit	1.20	ENSDART00000150983	camk2a NCBI UniProt Show fit	calcium/calmodulin-dependent protein kinase II alpha
chr10_-_32851847 Show fit	1.17	ENSDART00000134255	trim37 NCBI UniProt Show fit	tripartite motif containing 37
chr11_+_77526 Show fit	1.15	ENSDART00000193521	CABZ01072242.1 NCBI UniProt Show fit
chr25_-_12906872 Show fit	1.12	ENSDART00000165156 ENSDART00000167449	sept15 NCBI UniProt Show fit	septin 15
chr2_+_47582681 Show fit	1.10	ENSDART00000187579	scg2b NCBI UniProt Show fit	secretogranin II (chromogranin C), b

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of egr2a+egr2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.4	GO:0051289	protein homotetramerization(GO:0051289)
0.1	2.0	GO:0035308	negative regulation of dephosphorylation(GO:0035305) negative regulation of protein dephosphorylation(GO:0035308)
0.0	1.8	GO:1903670	regulation of sprouting angiogenesis(GO:1903670)
0.0	1.8	GO:0016579	protein deubiquitination(GO:0016579)
0.1	1.6	GO:0045773	positive regulation of axon extension(GO:0045773)
0.1	1.5	GO:0055003	cardiac myofibril assembly(GO:0055003)
0.0	1.4	GO:0003146	heart jogging(GO:0003146)
0.1	1.3	GO:0051965	positive regulation of synapse assembly(GO:0051965)
0.2	1.2	GO:0048011	neurotrophin TRK receptor signaling pathway(GO:0048011)
0.2	1.2	GO:0046600	negative regulation of centriole replication(GO:0046600)

Showing 1 to 10 of 130 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.5	GO:0045211	postsynaptic membrane(GO:0045211)
0.0	2.3	GO:0031225	anchored component of membrane(GO:0031225)
0.0	2.3	GO:0030141	secretory granule(GO:0030141)
0.0	2.0	GO:0030027	lamellipodium(GO:0030027)
0.1	1.7	GO:0044295	axonal growth cone(GO:0044295)
0.0	1.7	GO:0005940	septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.2	1.2	GO:0016234	inclusion body(GO:0016234)
0.0	1.2	GO:0043025	neuronal cell body(GO:0043025)
0.2	1.1	GO:0005955	calcineurin complex(GO:0005955)
0.0	0.9	GO:0043197	dendritic spine(GO:0043197) neuron spine(GO:0044309)

Showing 1 to 10 of 56 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.6	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.2	2.4	GO:0005522	profilin binding(GO:0005522)
0.0	2.0	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1	1.6	GO:0051721	protein phosphatase 2A binding(GO:0051721)
0.0	1.2	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	1.2	GO:0031625	ubiquitin protein ligase binding(GO:0031625)
0.2	1.1	GO:0033192	calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1	1.1	GO:0015026	coreceptor activity(GO:0015026)
0.0	1.0	GO:0019003	GDP binding(GO:0019003)
0.0	1.0	GO:0051087	chaperone binding(GO:0051087)

Showing 1 to 10 of 95 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.9	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.0	1.1	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	1.0	PID BMP PATHWAY	BMP receptor signaling
0.0	0.9	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	0.8	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	0.7	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	0.7	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	0.6	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	0.5	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0	0.5	PID NCADHERIN PATHWAY	N-cadherin signaling events

Showing 1 to 10 of 23 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	1.9	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.0	0.9	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.1	0.8	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	0.8	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.1	0.7	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	0.7	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0	0.7	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.0	0.6	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.6	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
0.0	0.5	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules

Showing 1 to 10 of 29 entries

Results for egr2a+egr2b

Z-value: 1.78

Motif logo

Transcription factors associated with egr2a+egr2b

Activity-expression correlation:

Activity profile of egr2a+egr2b motif

Sorted Z-values of egr2a+egr2b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of egr2a+egr2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: