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PRJNA207719: Tissue specific transcriptome profiling
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Results for egr1
Z-value: 0.81
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Transcription factors associated with egr1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| egr1 | dr11_v1_chr14_-_21336385_21336385 | 0.29 | 6.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_22535 Show fit | 1.74 |
ENSDART00000157877
|
|
|
| chr20_-_54462551 Show fit | 0.96 |
ENSDART00000171769
ENSDART00000169692 |
Enah/Vasp-like b |
|
| chr2_-_48753873 Show fit | 0.82 |
ENSDART00000189556
|
|
|
| chr23_+_37323962 Show fit | 0.67 |
ENSDART00000102881
|
family with sequence similarity 43, member B |
|
| chr2_+_47582681 Show fit | 0.65 |
ENSDART00000187579
|
secretogranin II (chromogranin C), b |
|
| chr2_+_47582488 Show fit | 0.63 |
ENSDART00000149967
|
secretogranin II (chromogranin C), b |
|
| chr24_+_24923166 Show fit | 0.61 |
ENSDART00000065288
|
phosphate cytidylyltransferase 1, choline, beta a |
|
| chr2_+_38924975 Show fit | 0.59 |
ENSDART00000109219
|
RAS (RAD and GEM)-like GTP binding 2 |
|
| chr25_+_34984333 Show fit | 0.53 |
ENSDART00000154760
|
coiled-coil domain containing 136b |
|
| chr9_-_18877597 Show fit | 0.51 |
ENSDART00000099446
|
potassium channel tetramerization domain containing 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of egr1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0051289 | protein homotetramerization(GO:0051289) |
| 0.0 | 0.7 | GO:0033173 | calcineurin-NFAT signaling cascade(GO:0033173) |
| 0.0 | 0.7 | GO:1903670 | regulation of sprouting angiogenesis(GO:1903670) |
| 0.1 | 0.6 | GO:0048790 | maintenance of presynaptic active zone structure(GO:0048790) maintenance of synapse structure(GO:0099558) |
| 0.0 | 0.6 | GO:0071542 | dopaminergic neuron differentiation(GO:0071542) |
| 0.1 | 0.5 | GO:0033206 | meiotic cytokinesis(GO:0033206) polar body extrusion after meiotic divisions(GO:0040038) |
| 0.1 | 0.5 | GO:0097374 | sensory neuron axon guidance(GO:0097374) |
| 0.0 | 0.5 | GO:2000054 | negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054) |
| 0.1 | 0.4 | GO:0015824 | proline transport(GO:0015824) |
| 0.1 | 0.4 | GO:0010807 | regulation of synaptic vesicle priming(GO:0010807) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0030141 | secretory granule(GO:0030141) |
| 0.1 | 0.7 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.0 | 0.7 | GO:0043679 | axon terminus(GO:0043679) |
| 0.0 | 0.6 | GO:0048788 | cytoskeleton of presynaptic active zone(GO:0048788) |
| 0.1 | 0.4 | GO:0070044 | synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044) |
| 0.1 | 0.3 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.1 | 0.3 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.0 | 0.3 | GO:0016234 | inclusion body(GO:0016234) |
| 0.0 | 0.3 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 0.3 | GO:0043209 | myelin sheath(GO:0043209) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | GO:0005522 | profilin binding(GO:0005522) |
| 0.1 | 0.7 | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.1 | 0.7 | GO:0031628 | opioid receptor binding(GO:0031628) |
| 0.1 | 0.6 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.0 | 0.6 | GO:0098882 | structural constituent of presynaptic active zone(GO:0098882) |
| 0.0 | 0.6 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.1 | 0.5 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
| 0.1 | 0.4 | GO:0005483 | soluble NSF attachment protein activity(GO:0005483) |
| 0.1 | 0.4 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.0 | 0.4 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.6 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.0 | 0.3 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 0.2 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 0.6 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.1 | 0.5 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 0.4 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.2 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.0 | 0.2 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 0.1 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 0.1 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |