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PRJNA207719: Tissue specific transcriptome profiling
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Results for ebf3a-2+ebf3b
Z-value: 1.03
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Transcription factors associated with ebf3a-2+ebf3b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ebf3a | dr11_v1_chr12_+_42436920_42436920 | 0.82 | 8.6e-02 | Click! |
| ebf3b | dr11_v1_chr17_-_20229812_20229812 | 0.75 | 1.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr23_-_21471022 Show fit | 0.92 |
ENSDART00000104206
|
hairy-related 4, tandem duplicate 2 |
|
| chr20_+_34933183 Show fit | 0.79 |
ENSDART00000062738
|
synaptosomal-associated protein, 25a |
|
| chr1_-_21409877 Show fit | 0.78 |
ENSDART00000102782
|
glutamate receptor, ionotropic, AMPA 2a |
|
| chr8_+_31821396 Show fit | 0.75 |
ENSDART00000077053
|
phosphatidylinositol-specific phospholipase C, X domain containing 3 |
|
| chr15_+_1372343 Show fit | 0.66 |
ENSDART00000152285
|
schwannomin interacting protein 1 |
|
| chr21_-_24632778 Show fit | 0.60 |
ENSDART00000132533
ENSDART00000058370 |
Rho GTPase activating protein 32b |
|
| chr23_+_21455152 Show fit | 0.59 |
ENSDART00000158511
ENSDART00000161321 ENSDART00000160731 ENSDART00000137573 |
hairy-related 4, tandem duplicate 2 |
|
| chr9_-_31278048 Show fit | 0.57 |
ENSDART00000022204
|
zic family member 5 (odd-paired homolog, Drosophila) |
|
| chr3_-_28665291 Show fit | 0.57 |
ENSDART00000151670
|
F-box and leucine-rich repeat protein 16 |
|
| chr6_+_55277419 Show fit | 0.57 |
ENSDART00000083670
|
|
Network of associatons between targets according to the STRING database.
First level regulatory network of ebf3a-2+ebf3b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | GO:0048936 | peripheral nervous system neuron axonogenesis(GO:0048936) |
| 0.0 | 0.8 | GO:0048899 | anterior lateral line development(GO:0048899) |
| 0.0 | 0.8 | GO:0016082 | synaptic vesicle priming(GO:0016082) |
| 0.1 | 0.7 | GO:0035332 | positive regulation of hippo signaling(GO:0035332) |
| 0.1 | 0.6 | GO:0033278 | cell proliferation in midbrain(GO:0033278) |
| 0.2 | 0.5 | GO:0097378 | interneuron axon guidance(GO:0097376) spinal cord interneuron axon guidance(GO:0097377) dorsal spinal cord interneuron axon guidance(GO:0097378) |
| 0.0 | 0.5 | GO:0006007 | glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.0 | 0.5 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.0 | 0.5 | GO:0014823 | response to activity(GO:0014823) |
| 0.0 | 0.5 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.0 | 0.8 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 0.6 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.1 | 0.5 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.0 | 0.5 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.0 | 0.4 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 0.3 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 0.2 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
| 0.0 | 0.1 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.0 | 0.1 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.0 | 0.8 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 0.6 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.0 | 0.5 | GO:0070095 | 6-phosphofructokinase activity(GO:0003872) fructose-6-phosphate binding(GO:0070095) |
| 0.1 | 0.4 | GO:0005252 | open rectifier potassium channel activity(GO:0005252) |
| 0.0 | 0.4 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.0 | 0.4 | GO:0005042 | netrin receptor activity(GO:0005042) |
| 0.0 | 0.4 | GO:0005452 | inorganic anion exchanger activity(GO:0005452) |
| 0.0 | 0.4 | GO:0004016 | adenylate cyclase activity(GO:0004016) |
| 0.0 | 0.4 | GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 0.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.3 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 0.3 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.0 | 0.3 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.0 | 0.3 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 0.2 | REACTOME ACYL CHAIN REMODELLING OF PI | Genes involved in Acyl chain remodelling of PI |
| 0.0 | 0.2 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.1 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |