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PRJNA207719: Tissue specific transcriptome profiling
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Results for e4f1+si:dkeyp-79b7.12
Z-value: 1.11
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Transcription factors associated with e4f1+si:dkeyp-79b7.12
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| e4f1 | dr11_v1_chr3_-_18737126_18737126 | 0.82 | 9.1e-02 | Click! |
| si:dkeyp-79b7.12 | dr11_v1_chr22_+_2207502_2207502 | 0.45 | 4.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr24_-_7632187 Show fit | 1.25 |
ENSDART00000041714
|
ATPase H+ transporting V0 subunit a1b |
|
| chr15_-_163586 Show fit | 1.22 |
ENSDART00000163597
|
septin-4 |
|
| chr2_-_42415902 Show fit | 1.10 |
ENSDART00000142489
|
solute carrier organic anion transporter family member 5A1b |
|
| chr23_-_35694461 Show fit | 1.10 |
ENSDART00000185884
|
tubulin, alpha 1c |
|
| chr9_+_21722733 Show fit | 1.04 |
ENSDART00000102021
|
SRY (sex determining region Y)-box 1a |
|
| chr23_-_35694171 Show fit | 1.03 |
ENSDART00000077539
|
tubulin, alpha 1c |
|
| chr23_-_29668286 Show fit | 0.95 |
ENSDART00000129248
|
calsyntenin 1 |
|
| chr4_+_9669717 Show fit | 0.94 |
ENSDART00000004604
|
si:dkey-153k10.9 |
|
| chr20_+_29743904 Show fit | 0.85 |
ENSDART00000146366
ENSDART00000153154 |
kinase D-interacting substrate 220b |
|
| chr1_-_51606552 Show fit | 0.85 |
ENSDART00000130828
|
cannabinoid receptor interacting protein 1a |
Network of associatons between targets according to the STRING database.
First level regulatory network of e4f1+si:dkeyp-79b7.12
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.2 | GO:0051452 | vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452) |
| 0.1 | 1.1 | GO:0043507 | activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507) |
| 0.1 | 1.0 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.0 | 1.0 | GO:0051091 | positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091) |
| 0.2 | 0.9 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.1 | 0.8 | GO:2000272 | negative regulation of receptor activity(GO:2000272) |
| 0.0 | 0.7 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.2 | 0.6 | GO:1903792 | regulation of neurotransmitter uptake(GO:0051580) negative regulation of anion transport(GO:1903792) |
| 0.1 | 0.5 | GO:0038003 | opioid receptor signaling pathway(GO:0038003) |
| 0.0 | 0.5 | GO:0051127 | positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.2 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 0.0 | 1.1 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 0.9 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.0 | 0.5 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 0.4 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 0.3 | GO:0005956 | protein kinase CK2 complex(GO:0005956) |
| 0.0 | 0.3 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.0 | 0.3 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.0 | 0.2 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 0.2 | GO:0001401 | mitochondrial sorting and assembly machinery complex(GO:0001401) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 1.2 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.1 | 1.0 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.0 | 0.9 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.1 | 0.7 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.0 | 0.7 | GO:0022840 | leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842) |
| 0.1 | 0.6 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.1 | 0.6 | GO:0008515 | sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157) |
| 0.2 | 0.5 | GO:0001635 | adrenomedullin receptor activity(GO:0001605) calcitonin gene-related peptide receptor activity(GO:0001635) |
| 0.2 | 0.5 | GO:0038046 | enkephalin receptor activity(GO:0038046) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 0.5 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 0.4 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 0.2 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 0.5 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.5 | REACTOME G PROTEIN ACTIVATION | Genes involved in G-protein activation |
| 0.0 | 0.3 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.0 | 0.2 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.0 | 0.2 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.0 | 0.2 | REACTOME SIGNALING BY NOTCH4 | Genes involved in Signaling by NOTCH4 |