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PRJNA207719: Tissue specific transcriptome profiling
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Results for e2f8
Z-value: 0.93
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Transcription factors associated with e2f8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| e2f8 | dr11_v1_chr7_-_16597130_16597130 | 0.18 | 7.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_14155781 Show fit | 0.69 |
ENSDART00000169232
|
nuclear receptor subfamily 0, group B, member 2b |
|
| chr14_+_46223458 Show fit | 0.60 |
ENSDART00000173428
|
calcium binding protein 2b |
|
| chr24_-_2829049 Show fit | 0.56 |
ENSDART00000164913
|
si:ch211-152c8.5 |
|
| chr4_-_2380173 Show fit | 0.55 |
ENSDART00000177727
|
nucleosome assembly protein 1-like 1 |
|
| chr7_+_24814866 Show fit | 0.54 |
ENSDART00000173581
|
si:ch211-226l4.6 |
|
| chr9_+_33220342 Show fit | 0.50 |
ENSDART00000100893
ENSDART00000113451 |
si:ch211-125e6.13 |
|
| chr11_-_29685853 Show fit | 0.45 |
ENSDART00000128468
|
nuclear receptor subfamily 0, group B, member 1 |
|
| chr6_-_40071899 Show fit | 0.44 |
ENSDART00000034730
|
Sec61 translocon alpha 1 subunit |
|
| chr3_-_5016893 Show fit | 0.37 |
ENSDART00000165968
|
cold shock domain containing C2 |
|
| chr6_+_50451337 Show fit | 0.36 |
ENSDART00000155051
|
myelocytomatosis oncogene homolog |
Network of associatons between targets according to the STRING database.
First level regulatory network of e2f8
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.7 | GO:0006335 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.0 | 0.7 | GO:0043433 | negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433) |
| 0.1 | 0.5 | GO:0008584 | male gonad development(GO:0008584) |
| 0.0 | 0.5 | GO:0019730 | antimicrobial humoral response(GO:0019730) |
| 0.0 | 0.5 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.0 | 0.5 | GO:0001878 | response to yeast(GO:0001878) |
| 0.1 | 0.4 | GO:0031204 | posttranslational protein targeting to membrane, translocation(GO:0031204) |
| 0.0 | 0.4 | GO:0006267 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299) |
| 0.0 | 0.4 | GO:0021955 | central nervous system neuron axonogenesis(GO:0021955) |
| 0.1 | 0.3 | GO:0070278 | extracellular matrix constituent secretion(GO:0070278) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0005784 | Sec61 translocon complex(GO:0005784) |
| 0.0 | 0.4 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 0.3 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.0 | 0.3 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.1 | 0.2 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.1 | 0.2 | GO:0032301 | MutSalpha complex(GO:0032301) |
| 0.0 | 0.2 | GO:0031298 | replication fork protection complex(GO:0031298) |
| 0.0 | 0.2 | GO:0000811 | GINS complex(GO:0000811) |
| 0.0 | 0.2 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 0.0 | 0.2 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.2 | 0.5 | GO:0042806 | fucose binding(GO:0042806) |
| 0.0 | 0.5 | GO:0030515 | snoRNA binding(GO:0030515) |
| 0.0 | 0.5 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 0.4 | GO:0005461 | UDP-glucuronic acid transmembrane transporter activity(GO:0005461) UDP-N-acetylgalactosamine transmembrane transporter activity(GO:0005463) |
| 0.1 | 0.4 | GO:0051185 | coenzyme transporter activity(GO:0051185) |
| 0.0 | 0.4 | GO:0008320 | protein transmembrane transporter activity(GO:0008320) |
| 0.1 | 0.3 | GO:0016743 | carboxyl- or carbamoyltransferase activity(GO:0016743) |
| 0.0 | 0.3 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
| 0.0 | 0.3 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.1 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.0 | 0.5 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.0 | 0.5 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.4 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 0.3 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.0 | 0.3 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.0 | 0.3 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 0.1 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |