ISMARA results: e2f4

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PRJNA207719: Tissue specific transcriptome profiling

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Results for e2f4

Z-value: 0.67

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Transcription factors associated with e2f4

Gene Symbol	Gene ID	Gene Info
e2f4 NCBI UniProt	ENSDARG00000101578	E2F transcription factor 4
e2f4 NCBI UniProt	ENSDARG00000109320	E2F transcription factor 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
e2f4	dr11_v1_chr25_+_17405201_17405201	-0.73	1.7e-01	Click!

Activity profile of e2f4 motif

Sorted Z-values of e2f4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_48391415 Show fit	0.58	ENSDART00000170726 ENSDART00000169577	si:ch73-359m17.2 NCBI UniProt Show fit	si:ch73-359m17.2
chr7_+_24814866 Show fit	0.58	ENSDART00000173581	si:ch211-226l4.6 NCBI UniProt Show fit	si:ch211-226l4.6
chr7_+_24881680 Show fit	0.48	ENSDART00000058843	krcp NCBI UniProt Show fit	kelch repeat-containing protein
chr20_-_29498178 Show fit	0.40	ENSDART00000152986 ENSDART00000027851 ENSDART00000152954	rrm2 NCBI UniProt Show fit	ribonucleotide reductase M2 polypeptide
chr19_-_47570672 Show fit	0.39	ENSDART00000112155	rrm2 NCBI UniProt Show fit	ribonucleotide reductase M2 polypeptide
chr3_+_29641181 Show fit	0.38	ENSDART00000151517	eif3d NCBI UniProt Show fit	eukaryotic translation initiation factor 3, subunit D
chr22_+_3153876 Show fit	0.36	ENSDART00000163327	rpl36 NCBI UniProt Show fit	ribosomal protein L36
chr7_-_6429031 Show fit	0.33	ENSDART00000173413	zgc:112234 NCBI UniProt Show fit	zgc:112234
chr25_-_774350 Show fit	0.31	ENSDART00000166321 ENSDART00000160386	IRAK4 NCBI UniProt Show fit	interleukin 1 receptor associated kinase 4
chr25_+_192116 Show fit	0.30	ENSDART00000153983	zgc:114188 NCBI UniProt Show fit	zgc:114188

Showing 1 to 10 of 64 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	GO:0009263	deoxyribonucleotide biosynthetic process(GO:0009263)
0.1	0.4	GO:0002191	cap-dependent translational initiation(GO:0002191)
0.0	0.3	GO:0051445	regulation of meiotic cell cycle(GO:0051445)
0.0	0.2	GO:1902299	pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.0	0.2	GO:0030719	P granule organization(GO:0030719)
0.0	0.1	GO:0002566	somatic diversification of immune receptors via somatic mutation(GO:0002566) pyrimidine dimer repair(GO:0006290) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.0	0.1	GO:0000710	meiotic mismatch repair(GO:0000710)
0.0	0.1	GO:0008207	C21-steroid hormone metabolic process(GO:0008207)

Showing 1 to 8 of 8 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.7	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	0.4	GO:0016282	eukaryotic 43S preinitiation complex(GO:0016282)
0.1	0.2	GO:0033391	chromatoid body(GO:0033391)
0.1	0.2	GO:0031390	Ctf18 RFC-like complex(GO:0031390)
0.0	0.2	GO:0042555	MCM complex(GO:0042555)
0.0	0.1	GO:0032301	MutSalpha complex(GO:0032301)
0.0	0.1	GO:0070652	HAUS complex(GO:0070652)

Showing 1 to 7 of 7 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.6	GO:0004129	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1	0.4	GO:0098808	mRNA cap binding(GO:0098808)
0.0	0.2	GO:0043140	ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518)
0.0	0.2	GO:0004142	diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0	0.1	GO:0032138	guanine/thymine mispair binding(GO:0032137) single base insertion or deletion binding(GO:0032138) single thymine insertion binding(GO:0032143) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357) mismatch repair complex binding(GO:0032404) MutLalpha complex binding(GO:0032405)
0.0	0.1	GO:0022850	serotonin-gated cation channel activity(GO:0022850)
0.0	0.1	GO:0030983	mismatched DNA binding(GO:0030983)

Showing 1 to 8 of 8 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling

Showing 1 to 1 of 1 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
0.8	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.3	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.2	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.2	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC

Showing 1 to 4 of 4 entries

Results for e2f4

Z-value: 0.67

Motif logo

Transcription factors associated with e2f4

Activity-expression correlation:

Activity profile of e2f4 motif

Sorted Z-values of e2f4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: