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PRJNA207719: Tissue specific transcriptome profiling
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Results for e2f2_e2f5
Z-value: 2.65
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Transcription factors associated with e2f2_e2f5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F2 | dr11_v1_chr17_-_27266053_27266053 | 0.52 | 3.7e-01 | Click! |
| e2f5 | dr11_v1_chr2_-_31686353_31686403 | -0.02 | 9.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_+_904850 Show fit | 4.28 |
ENSDART00000161847
|
si:ch73-208h1.1 |
|
| chr9_-_2892250 Show fit | 3.14 |
ENSDART00000140695
|
cell division cycle associated 7a |
|
| chr23_+_31815423 Show fit | 1.92 |
ENSDART00000075730
ENSDART00000075726 |
v-myb avian myeloblastosis viral oncogene homolog |
|
| chr20_+_39344889 Show fit | 1.90 |
ENSDART00000009164
|
establishment of sister chromatid cohesion N-acetyltransferase 2 |
|
| chr3_+_25999477 Show fit | 1.74 |
ENSDART00000024316
|
minichromosome maintenance complex component 5 |
|
| chr9_-_2892045 Show fit | 1.73 |
ENSDART00000137201
|
cell division cycle associated 7a |
|
| chr24_-_35561672 Show fit | 1.61 |
ENSDART00000058564
|
minichromosome maintenance complex component 4 |
|
| chr11_-_11792766 Show fit | 1.59 |
ENSDART00000011657
|
cell division cycle 6 homolog (S. cerevisiae) |
|
| chr20_+_34770197 Show fit | 1.55 |
ENSDART00000018304
|
minichromosome maintenance complex component 3 |
|
| chr1_+_19538299 Show fit | 1.47 |
ENSDART00000109416
|
structural maintenance of chromosomes 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of e2f2_e2f5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 6.0 | GO:0000727 | double-strand break repair via break-induced replication(GO:0000727) |
| 0.1 | 5.0 | GO:0048538 | thymus development(GO:0048538) |
| 0.4 | 4.6 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 0.6 | 4.3 | GO:1902975 | cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975) |
| 0.4 | 3.6 | GO:0044030 | regulation of DNA methylation(GO:0044030) |
| 0.3 | 2.2 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 0.3 | 2.0 | GO:0033567 | DNA replication, Okazaki fragment processing(GO:0033567) |
| 0.6 | 1.9 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
| 0.3 | 1.9 | GO:0030852 | regulation of granulocyte differentiation(GO:0030852) regulation of neutrophil differentiation(GO:0045658) |
| 0.1 | 1.6 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 7.9 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 7.0 | GO:0000785 | chromatin(GO:0000785) |
| 0.4 | 3.1 | GO:0031261 | DNA replication preinitiation complex(GO:0031261) |
| 0.2 | 2.2 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.1 | 1.4 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.2 | 0.9 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 0.1 | 0.9 | GO:0000792 | heterochromatin(GO:0000792) |
| 0.0 | 0.8 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.2 | 0.7 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 0.1 | 0.7 | GO:0031298 | replication fork protection complex(GO:0031298) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 11.1 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.5 | 3.6 | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.0 | 2.9 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 2.2 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
| 0.0 | 1.8 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 1.8 | GO:0016407 | acetyltransferase activity(GO:0016407) |
| 0.3 | 1.6 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 0.1 | 1.6 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.2 | 1.5 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.2 | 1.2 | GO:0019136 | deoxynucleoside kinase activity(GO:0019136) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.9 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 2.2 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 2.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 2.0 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 1.3 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 1.2 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 1.2 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 1.2 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 1.1 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.0 | 0.9 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 9.2 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.3 | 8.2 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.0 | 2.3 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.2 | 2.1 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.2 | 2.0 | REACTOME EARLY PHASE OF HIV LIFE CYCLE | Genes involved in Early Phase of HIV Life Cycle |
| 0.1 | 1.1 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.1 | 0.9 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.0 | 0.9 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 0.8 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.8 | REACTOME HIV LIFE CYCLE | Genes involved in HIV Life Cycle |