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PRJNA207719: Tissue specific transcriptome profiling

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Results for e2f2_e2f5

Z-value: 2.65

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Transcription factors associated with e2f2_e2f5

Gene Symbol Gene ID Gene Info
ENSDARG00000079233 si_ch211-160f23.5
ENSDARG00000038812 E2F transcription factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2F2dr11_v1_chr17_-_27266053_272660530.523.7e-01Click!
e2f5dr11_v1_chr2_-_31686353_31686403-0.029.8e-01Click!

Activity profile of e2f2_e2f5 motif

Sorted Z-values of e2f2_e2f5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_904850 4.28 ENSDART00000161847
si:ch73-208h1.1
chr9_-_2892250 3.14 ENSDART00000140695
cell division cycle associated 7a
chr23_+_31815423 1.92 ENSDART00000075730
ENSDART00000075726
v-myb avian myeloblastosis viral oncogene homolog
chr20_+_39344889 1.90 ENSDART00000009164
establishment of sister chromatid cohesion N-acetyltransferase 2
chr3_+_25999477 1.74 ENSDART00000024316
minichromosome maintenance complex component 5
chr9_-_2892045 1.73 ENSDART00000137201
cell division cycle associated 7a
chr24_-_35561672 1.61 ENSDART00000058564
minichromosome maintenance complex component 4
chr11_-_11792766 1.59 ENSDART00000011657
cell division cycle 6 homolog (S. cerevisiae)
chr20_+_34770197 1.55 ENSDART00000018304
minichromosome maintenance complex component 3
chr1_+_19538299 1.47 ENSDART00000109416
structural maintenance of chromosomes 2
chr3_-_54607166 1.44 ENSDART00000021977
DNA (cytosine-5-)-methyltransferase 1
chr13_+_8255106 1.31 ENSDART00000080465
helicase, lymphoid specific
chr8_+_52415603 1.29 ENSDART00000021604
ENSDART00000191424
GINS complex subunit 4 (Sld5 homolog)
chr8_-_1219815 1.21 ENSDART00000016800
ENSDART00000149969
zinc finger protein 367
chr19_-_47571797 1.19 ENSDART00000166180
ENSDART00000168134
ribonucleotide reductase M2 polypeptide
chr21_-_26490186 1.17 ENSDART00000009889
zgc:110540
chr7_+_71535045 1.01 ENSDART00000047069
thymidylate synthetase
chr20_+_23440632 0.99 ENSDART00000180685
ENSDART00000042820
si:dkey-90m5.4
chr10_-_21362071 0.99 ENSDART00000125167
avidin
chr6_+_12968101 0.98 ENSDART00000013781
minichromosome maintenance complex component 6
chr18_-_5595546 0.97 ENSDART00000191825
cytochrome P450, family 1, subfamily A
chr8_-_4760723 0.96 ENSDART00000064201
CDC45 cell division cycle 45 homolog (S. cerevisiae)
chr19_-_47571456 0.95 ENSDART00000158071
ENSDART00000165841
ribonucleotide reductase M2 polypeptide
chr20_-_23439011 0.94 ENSDART00000022887
solute carrier family 10, member 4
chr15_-_17099560 0.91 ENSDART00000101724
v-mos Moloney murine sarcoma viral oncogene homolog
chr25_-_35095129 0.90 ENSDART00000099866
ENSDART00000099868
kinesin family member 15
chr8_-_12403077 0.90 ENSDART00000142150
PHD finger protein 19
chr6_+_32046202 0.89 ENSDART00000156552
si:dkey-148h10.5
chr3_+_37112693 0.88 ENSDART00000055228
ENSDART00000144278
ENSDART00000138079
PSMC3 interacting protein
chr22_-_4439311 0.85 ENSDART00000169317
ubiquitin-like with PHD and ring finger domains 1
chr21_+_22558187 0.84 ENSDART00000167599
checkpoint kinase 1
chr4_-_77561679 0.81 ENSDART00000180809

chr6_+_59029485 0.80 ENSDART00000050140

chr17_+_25481466 0.78 ENSDART00000139451
crystallin beta-gamma domain containing 1a
chr24_+_11908480 0.76 ENSDART00000024224
flap structure-specific endonuclease 1
chr19_-_2822372 0.76 ENSDART00000109130
ENSDART00000122385
RecQ helicase-like 4
chr13_-_13030851 0.76 ENSDART00000009499
nuclear receptor binding SET domain protein 2
chr11_-_309420 0.76 ENSDART00000173185
POC1 centriolar protein A
chr20_-_29499363 0.74 ENSDART00000152889
ENSDART00000153252
ENSDART00000170972
ENSDART00000166420
ENSDART00000163079
ribonucleotide reductase M2 polypeptide
chr4_+_76748500 0.74 ENSDART00000075607
membrane-spanning 4-domains, subfamily A, member 17A.10
chr22_-_3152357 0.74 ENSDART00000170983
lamin B2
chr3_+_22335030 0.73 ENSDART00000055676
zgc:103564
chr6_+_50451337 0.73 ENSDART00000155051
myelocytomatosis oncogene homolog
chr24_+_11908833 0.72 ENSDART00000178622
flap structure-specific endonuclease 1
chr5_-_19014589 0.71 ENSDART00000002624
RAN binding protein 1
chr21_-_233282 0.71 ENSDART00000157684
brix domain containing 2
chr7_+_55518519 0.70 ENSDART00000098476
ENSDART00000149915
chromatin licensing and DNA replication factor 1
chr16_-_43335914 0.70 ENSDART00000111963
ATPase family, AAA domain containing 2
chr5_+_12743640 0.68 ENSDART00000081411
polymerase (DNA directed), epsilon
chr20_-_23440955 0.68 ENSDART00000153386
solute carrier family 10, member 4
chr20_-_29498178 0.68 ENSDART00000152986
ENSDART00000027851
ENSDART00000152954
ribonucleotide reductase M2 polypeptide
chr17_+_8799661 0.67 ENSDART00000105326
tonsoku-like, DNA repair protein
chr7_+_34236238 0.66 ENSDART00000052474
timeless interacting protein
chr15_-_2954443 0.66 ENSDART00000161053
zgc:153184
chr6_+_33931740 0.66 ENSDART00000130492
ENSDART00000151213
origin recognition complex, subunit 1
chr24_+_23840821 0.64 ENSDART00000128595
ENSDART00000127188
polymerase (DNA directed), alpha 1
chr20_+_4392687 0.64 ENSDART00000187271
im:7142702
chr3_+_26244353 0.63 ENSDART00000103733
ATPase family, AAA domain containing 5a
chr6_-_1762191 0.61 ENSDART00000167928
origin recognition complex, subunit 4
chr19_-_7144548 0.56 ENSDART00000147177
ENSDART00000134850
proteasome subunit beta 8A
proteasome subunit beta 13a
chr2_-_44777592 0.55 ENSDART00000113351
ENSDART00000169310
non-SMC condensin I complex, subunit D2
chr7_-_2143313 0.54 ENSDART00000173871
si:cabz01007807.1
chr25_-_13403726 0.54 ENSDART00000056723
GINS complex subunit 3
chr25_+_186583 0.53 ENSDART00000161504
PCNA clamp associated factor
chr1_+_58375871 0.53 ENSDART00000166736

chr1_-_59216197 0.52 ENSDART00000062426
lysophosphatidic acid receptor 2b
chr2_-_44344321 0.52 ENSDART00000084174
ligase I, DNA, ATP-dependent
chr1_+_9199031 0.52 ENSDART00000092058
ENSDART00000182771
CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
chr1_-_8553165 0.51 ENSDART00000135197
ENSDART00000054981
zgc:112980
chr7_-_6464225 0.51 ENSDART00000130760
histone cluster 1 H2A family member 4
chr13_-_36863018 0.50 ENSDART00000023449
ENSDART00000149011
phosphorylase, glycogen, liver
chr13_-_856525 0.48 ENSDART00000143356
zgc:163080
chr19_-_29294457 0.47 ENSDART00000130815
ENSDART00000103437
E2F transcription factor 3
chr5_+_32345187 0.46 ENSDART00000147132
complement component 9
chr13_-_35908275 0.45 ENSDART00000013961
MYCL proto-oncogene, bHLH transcription factor a
chr2_-_29923403 0.44 ENSDART00000144672
PAX interacting (with transcription-activation domain) protein 1
chr2_+_44512324 0.44 ENSDART00000155017
ENSDART00000156310
ENSDART00000156686
PAS domain containing serine/threonine kinase
chr17_+_8799451 0.43 ENSDART00000189814
ENSDART00000191577
tonsoku-like, DNA repair protein
chr4_-_5831522 0.43 ENSDART00000008898
forkhead box M1
chr1_-_46663997 0.42 ENSDART00000134450
emopamil binding protein-like
chr8_-_13972626 0.40 ENSDART00000144296
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr7_+_71586485 0.39 ENSDART00000165582
structural maintenance of chromosomes flexible hinge domain containing 1
chr10_+_29849497 0.39 ENSDART00000099994
ENSDART00000132212
heat shock protein 8
chr3_-_16110351 0.39 ENSDART00000064838
LIM and SH3 protein 1
chr13_+_24584401 0.39 ENSDART00000057599
fucose mutarotase
chr16_-_9802449 0.39 ENSDART00000081208
TAP binding protein (tapasin)-like
chr16_-_14587332 0.39 ENSDART00000012479
DNA replication and sister chromatid cohesion 1
chr22_+_1708760 0.38 ENSDART00000170471
si:dkey-1b17.9
chr3_-_26244256 0.38 ENSDART00000103741
protein phosphatase 4, catalytic subunit a
chr9_-_30555725 0.38 ENSDART00000079222
chromatin assembly factor 1, subunit B
chr7_+_1550966 0.38 ENSDART00000177863
ENSDART00000126840
SPT16 homolog, facilitates chromatin remodeling subunit
chr8_-_2153147 0.38 ENSDART00000124093
si:dkeyp-117b11.1
chr16_+_33143503 0.37 ENSDART00000058471
ENSDART00000179385
rhomboid, veinlet-like 2 (Drosophila)
chr17_+_4325693 0.37 ENSDART00000154264
minichromosome maintenance 8 homologous recombination repair factor
chr5_+_69868911 0.37 ENSDART00000014649
ENSDART00000188215
ENSDART00000167385
UDP glucuronosyltransferase 2 family, polypeptide A5
chr10_-_35153388 0.37 ENSDART00000188132
receptor-interacting serine-threonine kinase 4
chr19_+_48060464 0.36 ENSDART00000123163
zgc:85936
chr24_-_11908115 0.36 ENSDART00000184329
transmembrane 9 superfamily member 1
chr18_-_30499489 0.36 ENSDART00000033746
GINS complex subunit 2
chr22_-_10752471 0.35 ENSDART00000081191
SAS-6 centriolar assembly protein
chr4_+_77933084 0.35 ENSDART00000148728
protein kinase C and casein kinase substrate in neurons 2
chr21_-_25741096 0.34 ENSDART00000181756
claudin h
chr6_-_51573975 0.34 ENSDART00000073865
retinoblastoma-like 1 (p107)
chr4_+_18441988 0.34 ENSDART00000040827
non-SMC condensin II complex, subunit H2
chr7_+_41812636 0.34 ENSDART00000174333
origin recognition complex, subunit 6
chr22_-_10591876 0.33 ENSDART00000105846
si:dkey-42i9.8
chr6_+_7533601 0.33 ENSDART00000057823
proliferation-associated 2G4, a
chr21_-_27413294 0.33 ENSDART00000131646
solute carrier family 29 (equilibrative nucleoside transporter), member 2
chr13_-_856701 0.32 ENSDART00000140423
zgc:163080
chr25_-_35140746 0.32 ENSDART00000129969
si:ch211-113a14.19
chr14_-_49859747 0.32 ENSDART00000169456
ENSDART00000164967
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr12_-_3962372 0.31 ENSDART00000016791
eukaryotic translation initiation factor 3, subunit C
chr1_-_201004 0.31 ENSDART00000188956

chr13_-_14929236 0.31 ENSDART00000020576
cell division cycle 25B
chr10_+_38775408 0.31 ENSDART00000125045
Down syndrome cell adhesion molecule a
chr7_+_19851422 0.31 ENSDART00000142970
ENSDART00000190027
MUS81 structure-specific endonuclease subunit
chr3_-_16110100 0.30 ENSDART00000051807
LIM and SH3 protein 1
chr7_+_24814866 0.30 ENSDART00000173581
si:ch211-226l4.6
chr19_-_12322356 0.30 ENSDART00000016128
neurocalcin delta b
chr16_+_50953547 0.30 ENSDART00000157526
si:dkeyp-97a10.1
chr22_-_5822147 0.29 ENSDART00000011076
ceramide synthase 5
chr10_+_38775959 0.29 ENSDART00000192990
Down syndrome cell adhesion molecule a
chr19_-_2582858 0.29 ENSDART00000113829
cell division cycle associated 7b
chr8_+_30112655 0.29 ENSDART00000099027
Fanconi anemia, complementation group C
chr5_-_22969424 0.29 ENSDART00000143869
ENSDART00000172549
si:dkey-237j10.2
chr20_-_54245256 0.29 ENSDART00000170482
PRP39 pre-mRNA processing factor 39 homolog (yeast)
chr2_+_48074243 0.29 ENSDART00000056291
Kruppel-like factor 6b
chr20_+_263056 0.29 ENSDART00000132669
tubulin, epsilon 1
chr7_+_41812190 0.29 ENSDART00000113732
ENSDART00000174137
origin recognition complex, subunit 6
chr16_+_68069 0.29 ENSDART00000185385
ENSDART00000159652
SRY (sex determining region Y)-box 4b
chr5_+_8256574 0.29 ENSDART00000171343

chr5_-_33255759 0.28 ENSDART00000085531
protein kinase, AMP-activated, alpha 1 catalytic subunit
chr25_+_36333993 0.28 ENSDART00000184379

chr13_-_35907768 0.28 ENSDART00000147522
MYCL proto-oncogene, bHLH transcription factor a
chr17_-_27266053 0.28 ENSDART00000110903
si:ch211-160f23.5
chr2_-_29923630 0.28 ENSDART00000158844
ENSDART00000031130
PAX interacting (with transcription-activation domain) protein 1
chr16_+_40575742 0.27 ENSDART00000161503
cyclin E2
chr8_-_38406831 0.27 ENSDART00000112991
ENSDART00000191445
sorbin and SH3 domain containing 3
chr19_+_43604643 0.27 ENSDART00000151168
si:ch211-199g17.9
chr5_+_27488975 0.27 ENSDART00000123635
secreted frizzled-related protein 1a
chr3_-_35865040 0.27 ENSDART00000102952
SUZ12 polycomb repressive complex 2a subunit
chr2_-_38363017 0.27 ENSDART00000088026
protein arginine methyltransferase 5
chr5_+_22969651 0.27 ENSDART00000089992
ENSDART00000145477
high mobility group nucleosomal binding domain 7
chr25_-_12824656 0.27 ENSDART00000171801
ubiquitin-like modifier activating enzyme 2
chr8_+_20415824 0.27 ENSDART00000009081
ENSDART00000145444
MOB kinase activator 3A
chr23_+_17839187 0.27 ENSDART00000104647
DNA primase subunit 1
chr14_+_80685 0.26 ENSDART00000188443
stromal antigen 3
chr14_+_94603 0.26 ENSDART00000162480
minichromosome maintenance complex component 7
chr21_+_45386033 0.26 ENSDART00000151773
jade family PHD finger 2
chr17_+_43889371 0.26 ENSDART00000156871
ENSDART00000154702
mutS homolog 4
chr24_+_17345521 0.25 ENSDART00000024722
ENSDART00000154250
enhancer of zeste 2 polycomb repressive complex 2 subunit
chr13_-_7432715 0.25 ENSDART00000158685
si:dkey-45k15.1
chr3_+_29458517 0.25 ENSDART00000134258
GRB2-related adaptor protein 2a
chr19_+_9455218 0.24 ENSDART00000139385
si:ch211-288g17.3
chr9_-_12652984 0.24 ENSDART00000052256
small ubiquitin-like modifier 3b
chr4_-_9909371 0.24 ENSDART00000102656
si:dkey-22l11.6
chr3_+_22984098 0.24 ENSDART00000043190
LSM12 homolog a
chr11_+_18216404 0.23 ENSDART00000086437
transmembrane and coiled-coil domain family 1b
chr10_+_21434649 0.23 ENSDART00000193938
ENSDART00000064558
eukaryotic translation termination factor 1b
chr25_+_3326885 0.23 ENSDART00000104866
lactate dehydrogenase Bb
chr1_-_12126535 0.23 ENSDART00000164817
ENSDART00000015251
microsomal triglyceride transfer protein
chr7_+_5913030 0.23 ENSDART00000160575
Histone H3.2
chr20_-_38827623 0.23 ENSDART00000153310
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr25_-_35144620 0.23 ENSDART00000185669
histone cluster 1 H2A family member 2
chr20_-_30376433 0.22 ENSDART00000190737
ribosomal protein S7
chr16_+_41015781 0.22 ENSDART00000124543
DEK proto-oncogene
chr10_+_14499201 0.22 ENSDART00000064901
katanin p60 subunit A-like 2
chr16_-_35586401 0.22 ENSDART00000169868
ENSDART00000166606
ENSDART00000162562
Scm polycomb group protein homolog 1
chr3_-_45777226 0.22 ENSDART00000192849
H3 histone, family 3B.1
chr4_-_2545310 0.22 ENSDART00000150619
ENSDART00000140760
E2F transcription factor 7
chr5_-_54395488 0.22 ENSDART00000160781
zinc finger, MYND-type containing 19
chr2_+_48073972 0.22 ENSDART00000186442
Kruppel-like factor 6b
chr17_-_49407091 0.22 ENSDART00000021950
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b
chr18_+_41560822 0.22 ENSDART00000158503
bromodomain adjacent to zinc finger domain, 1B
chr1_+_26677406 0.22 ENSDART00000183427
ENSDART00000180366
ENSDART00000181997
si:dkey-25o16.4
chr21_-_23017478 0.21 ENSDART00000024309
retinoblastoma 1
chr1_+_50976975 0.21 ENSDART00000022290
ENSDART00000140982
malate dehydrogenase 1Aa, NAD (soluble)
chr20_-_29633507 0.21 ENSDART00000040292
cleavage and polyadenylation specific factor 3
chr15_-_19334448 0.21 ENSDART00000062576
thymocyte nuclear protein 1
chr22_+_1930589 0.21 ENSDART00000159807
zinc finger protein 1153
chr14_+_46223458 0.21 ENSDART00000173428
calcium binding protein 2b
chr21_+_26522571 0.21 ENSDART00000134617
adenylosuccinate synthase, like
chr25_+_36327034 0.21 ENSDART00000073452
zgc:110216
chr7_-_37895771 0.20 ENSDART00000084282
PAP associated domain containing 5
chr2_-_47957673 0.20 ENSDART00000056305
frizzled class receptor 8b
chr21_-_30408775 0.20 ENSDART00000101037
NHP2 ribonucleoprotein homolog (yeast)
chr25_-_35145920 0.20 ENSDART00000157137
si:dkey-261m9.19
chr1_+_26676758 0.20 ENSDART00000152299
si:dkey-25o16.4
chr25_-_32363341 0.20 ENSDART00000153892
ENSDART00000114385
centrosomal protein 152
chr15_-_36347858 0.20 ENSDART00000155274
ENSDART00000157936
si:dkey-23k10.2
chr14_+_52563794 0.19 ENSDART00000168874
ribosomal protein L26
chr25_-_35047838 0.19 ENSDART00000155060

chr17_-_22573311 0.19 ENSDART00000141523
ENSDART00000140022
ENSDART00000079390
ENSDART00000188644
exonuclease 1
chr10_-_15644904 0.19 ENSDART00000138389
ENSDART00000101191
ENSDART00000186559
ENSDART00000122170
structural maintenance of chromosomes 5
chr6_-_32045951 0.19 ENSDART00000016629
ENSDART00000139055
EF-hand calcium binding domain 7
chr3_-_32275975 0.19 ENSDART00000178448
carnitine palmitoyltransferase 1Cb
chr19_-_20777351 0.19 ENSDART00000019206
N-glycanase 1
chr17_+_26828027 0.19 ENSDART00000042060
jade family PHD finger 1
chr4_+_70556298 0.18 ENSDART00000170985
si:dkey-11d20.1
chr7_-_69185124 0.18 ENSDART00000182217
ENSDART00000191359
ubiquitin specific peptidase 10

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f2_e2f5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0034421 post-translational protein acetylation(GO:0034421)
0.6 4.3 GO:1902975 cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975)
0.5 6.0 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.4 4.6 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.4 3.6 GO:0044030 regulation of DNA methylation(GO:0044030)
0.3 1.9 GO:0030852 regulation of granulocyte differentiation(GO:0030852) regulation of neutrophil differentiation(GO:0045658)
0.3 0.9 GO:1905132 meiotic cell cycle phase transition(GO:0044771) metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133)
0.3 2.0 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
0.3 2.2 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.3 0.8 GO:0097676 histone H3-K36 dimethylation(GO:0097676)
0.2 0.7 GO:0006272 leading strand elongation(GO:0006272)
0.2 1.4 GO:0000076 DNA replication checkpoint(GO:0000076)
0.2 0.9 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.2 0.4 GO:2000257 regulation of protein activation cascade(GO:2000257)
0.2 0.5 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 0.9 GO:0061641 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 0.7 GO:0046607 positive regulation of centrosome cycle(GO:0046607)
0.1 0.4 GO:0034088 maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.1 5.0 GO:0048538 thymus development(GO:0048538)
0.1 1.0 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 1.6 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 1.4 GO:0006270 DNA replication initiation(GO:0006270)
0.1 0.3 GO:0035751 regulation of lysosomal lumen pH(GO:0035751)
0.1 0.3 GO:0034969 histone arginine methylation(GO:0034969)
0.1 0.3 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.1 0.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 0.4 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1 0.2 GO:0021563 glossopharyngeal nerve development(GO:0021563)
0.1 1.4 GO:0031297 replication fork processing(GO:0031297)
0.1 1.5 GO:0030261 chromosome condensation(GO:0030261)
0.1 0.2 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.1 0.3 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.1 0.4 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260) protein localization to early endosome(GO:1902946)
0.1 0.4 GO:0006004 fucose metabolic process(GO:0006004)
0.1 0.1 GO:2000104 negative regulation of DNA-dependent DNA replication(GO:2000104)
0.1 0.4 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.1 0.3 GO:0015862 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.1 1.0 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.1 0.3 GO:1902751 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.1 0.3 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1 0.4 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.2 GO:0098535 de novo centriole assembly(GO:0098535)
0.0 0.4 GO:0043981 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.0 0.3 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.2 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.0 0.3 GO:0051673 membrane disruption in other organism(GO:0051673)
0.0 0.2 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.0 0.2 GO:0032875 regulation of DNA endoreduplication(GO:0032875) positive regulation of DNA endoreduplication(GO:0032877) DNA endoreduplication(GO:0042023)
0.0 0.2 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.0 0.4 GO:0000710 meiotic mismatch repair(GO:0000710)
0.0 0.4 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.0 0.2 GO:0060967 negative regulation of posttranscriptional gene silencing(GO:0060149) negative regulation of gene silencing by miRNA(GO:0060965) negative regulation of gene silencing by RNA(GO:0060967)
0.0 0.5 GO:0019985 translesion synthesis(GO:0019985)
0.0 0.1 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.0 0.4 GO:0071156 regulation of cell cycle arrest(GO:0071156)
0.0 0.1 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.0 0.5 GO:0044247 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 0.4 GO:0019883 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.3 GO:0044857 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.0 0.1 GO:0071169 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.0 0.6 GO:2000134 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.2 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.7 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 1.0 GO:0007131 reciprocal meiotic recombination(GO:0007131)
0.0 0.3 GO:0006298 mismatch repair(GO:0006298)
0.0 0.2 GO:0001579 medium-chain fatty acid transport(GO:0001579)
0.0 0.5 GO:0032508 DNA geometric change(GO:0032392) DNA duplex unwinding(GO:0032508)
0.0 0.1 GO:0015709 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.0 0.1 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.2 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.3 GO:0051601 exocyst localization(GO:0051601)
0.0 0.3 GO:0070193 synaptonemal complex assembly(GO:0007130) synaptonemal complex organization(GO:0070193)
0.0 0.0 GO:0048618 post-embryonic foregut morphogenesis(GO:0048618)
0.0 0.6 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.1 GO:0000012 single strand break repair(GO:0000012)
0.0 0.2 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.6 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 0.1 GO:0035790 regulation of platelet-derived growth factor receptor signaling pathway(GO:0010640) platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583)
0.0 0.2 GO:0021634 optic nerve formation(GO:0021634)
0.0 0.0 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.0 0.1 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.0 0.2 GO:0006517 protein deglycosylation(GO:0006517)
0.0 0.1 GO:0060019 radial glial cell differentiation(GO:0060019)
0.0 0.6 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.1 GO:0070084 protein initiator methionine removal(GO:0070084)
0.0 0.6 GO:0007062 sister chromatid cohesion(GO:0007062)
0.0 0.1 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.0 0.2 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.4 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.2 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 1.1 GO:0031497 chromatin assembly(GO:0031497)
0.0 0.3 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.4 GO:0045879 negative regulation of smoothened signaling pathway(GO:0045879)
0.0 0.2 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.3 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.0 1.2 GO:0030516 regulation of axon extension(GO:0030516)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.1 GO:0031261 DNA replication preinitiation complex(GO:0031261)
0.4 7.9 GO:0042555 MCM complex(GO:0042555)
0.2 2.2 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.2 0.6 GO:0098536 deuterosome(GO:0098536)
0.2 0.9 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.2 0.7 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.2 0.5 GO:0044215 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.1 0.6 GO:0033186 CAF-1 complex(GO:0033186)
0.1 0.7 GO:0031298 replication fork protection complex(GO:0031298)
0.1 0.4 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 1.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.3 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.1 0.3 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.1 0.9 GO:0000792 heterochromatin(GO:0000792)
0.1 0.4 GO:0035101 FACT complex(GO:0035101)
0.1 0.3 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.1 0.2 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.0 0.2 GO:0018444 translation release factor complex(GO:0018444)
0.0 0.3 GO:0000796 condensin complex(GO:0000796)
0.0 0.1 GO:0032301 MutSalpha complex(GO:0032301)
0.0 0.4 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.1 GO:0033391 chromatoid body(GO:0033391)
0.0 0.1 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.2 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.2 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 7.0 GO:0000785 chromatin(GO:0000785)
0.0 0.1 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.0 0.1 GO:0008278 cohesin complex(GO:0008278) meiotic cohesin complex(GO:0030893)
0.0 0.6 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.3 GO:0000243 commitment complex(GO:0000243)
0.0 0.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.2 GO:0071005 U2-type precatalytic spliceosome(GO:0071005)
0.0 0.1 GO:0034448 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.3 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.3 GO:0016282 eukaryotic 43S preinitiation complex(GO:0016282)
0.0 0.8 GO:0005643 nuclear pore(GO:0005643)
0.0 0.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.3 GO:0035102 PRC1 complex(GO:0035102)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.6 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.4 11.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.3 1.6 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.2 1.5 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.2 1.0 GO:0009374 biotin binding(GO:0009374)
0.2 0.7 GO:0070182 DNA polymerase binding(GO:0070182)
0.2 0.5 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.2 0.7 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.2 1.2 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.2 1.0 GO:0070330 aromatase activity(GO:0070330)
0.1 0.4 GO:0042806 fucose binding(GO:0042806)
0.1 0.5 GO:0043142 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) single-stranded DNA-dependent ATPase activity(GO:0043142)
0.1 1.6 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 0.5 GO:0004645 phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184)
0.1 0.3 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.1 0.8 GO:0009378 four-way junction helicase activity(GO:0009378)
0.1 0.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 0.2 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.1 0.5 GO:0048256 flap endonuclease activity(GO:0048256)
0.1 0.2 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.1 0.3 GO:0019948 SUMO activating enzyme activity(GO:0019948)
0.1 0.4 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.2 GO:0032574 5'-3' RNA helicase activity(GO:0032574)
0.1 0.2 GO:1904121 phosphatidylethanolamine transporter activity(GO:1904121)
0.1 0.3 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 0.6 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.4 GO:0035173 histone kinase activity(GO:0035173)
0.0 1.8 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0047453 ATP-dependent NAD(P)H-hydrate dehydratase activity(GO:0047453) ADP-dependent NAD(P)H-hydrate dehydratase activity(GO:0052855)
0.0 2.2 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.0 0.2 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.5 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.5 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.2 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.2 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.0 0.1 GO:0001734 mRNA (N6-adenosine)-methyltransferase activity(GO:0001734)
0.0 0.2 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.1 GO:0000217 DNA secondary structure binding(GO:0000217)
0.0 0.2 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0 0.6 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.2 GO:0008494 translation activator activity(GO:0008494)
0.0 0.2 GO:0001217 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.0 0.1 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
0.0 0.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 1.8 GO:0016407 acetyltransferase activity(GO:0016407)
0.0 0.2 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.1 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.0 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 0.6 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.3 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 2.9 GO:0042393 histone binding(GO:0042393)
0.0 0.2 GO:0031386 protein tag(GO:0031386)
0.0 0.3 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.2 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.0 0.2 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 0.3 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 0.3 GO:0017147 Wnt-protein binding(GO:0017147)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 11.9 PID E2F PATHWAY E2F transcription factor network
0.1 2.2 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.1 2.0 PID AURORA B PATHWAY Aurora B signaling
0.0 0.9 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 2.0 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.1 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 1.3 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.2 PID ATR PATHWAY ATR signaling pathway
0.0 1.2 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.4 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.3 PID FANCONI PATHWAY Fanconi anemia pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 9.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.3 8.2 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 2.0 REACTOME EARLY PHASE OF HIV LIFE CYCLE Genes involved in Early Phase of HIV Life Cycle
0.2 2.1 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 0.9 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 1.1 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 0.3 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.9 REACTOME KINESINS Genes involved in Kinesins
0.0 0.8 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.3 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.5 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 2.3 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.2 REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION Genes involved in E2F mediated regulation of DNA replication
0.0 0.4 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.4 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.2 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0 0.1 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.4 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.3 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.5 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.5 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.4 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.2 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.3 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.1 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.5 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.8 REACTOME HIV LIFE CYCLE Genes involved in HIV Life Cycle
0.0 0.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis