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PRJNA207719: Tissue specific transcriptome profiling

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Results for e2f1_e2f7

Z-value: 2.24

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Transcription factors associated with e2f1_e2f7

Gene Symbol Gene ID Gene Info
ENSDARG00000103868 E2F transcription factor 1
ENSDARG00000008986 E2F transcription factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
e2f1dr11_v1_chr23_-_43486714_434867140.961.1e-02Click!
e2f7dr11_v1_chr4_-_2545310_25453450.296.4e-01Click!

Activity profile of e2f1_e2f7 motif

Sorted Z-values of e2f1_e2f7 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_48391415 2.82 ENSDART00000170726
ENSDART00000169577
si:ch73-359m17.2
chr16_-_41990421 1.93 ENSDART00000055921
PYD and CARD domain containing
chr9_-_33081978 1.50 ENSDART00000100918
zgc:172053
chr5_+_22970617 1.48 ENSDART00000192859
high mobility group nucleosomal binding domain 7
chr8_-_1219815 1.33 ENSDART00000016800
ENSDART00000149969
zinc finger protein 367
chr6_+_12968101 1.33 ENSDART00000013781
minichromosome maintenance complex component 6
chr20_-_29498178 1.32 ENSDART00000152986
ENSDART00000027851
ENSDART00000152954
ribonucleotide reductase M2 polypeptide
chr3_+_25999477 1.27 ENSDART00000024316
minichromosome maintenance complex component 5
chr14_+_14841685 1.26 ENSDART00000158291
ENSDART00000162039
stem-loop binding protein
chr20_+_34770197 1.25 ENSDART00000018304
minichromosome maintenance complex component 3
chr19_-_47570672 1.23 ENSDART00000112155
ribonucleotide reductase M2 polypeptide
chr3_-_49514874 1.18 ENSDART00000167179
anti-silencing function 1Ba histone chaperone
chr19_-_5358443 1.18 ENSDART00000105036
type I cytokeratin, enveloping layer, like
chr24_-_35561672 1.10 ENSDART00000058564
minichromosome maintenance complex component 4
chr8_+_16407884 1.04 ENSDART00000133742
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr7_+_24881680 1.02 ENSDART00000058843
kelch repeat-containing protein
chr12_+_46883785 1.01 ENSDART00000008312
family with sequence similarity 53, member B
chr8_+_52415603 1.01 ENSDART00000021604
ENSDART00000191424
GINS complex subunit 4 (Sld5 homolog)
chr20_+_53521648 0.96 ENSDART00000139794
p21 protein (Cdc42/Rac)-activated kinase 6b
chr1_-_38170997 0.96 ENSDART00000142811
high mobility group box 2a
chr6_-_425378 0.96 ENSDART00000192190
family with sequence similarity 83, member Fb
chr13_-_86847 0.96 ENSDART00000158062
polymerase (DNA directed), epsilon 2
chr15_-_2640966 0.95 ENSDART00000063320
claudin e
chr8_+_16408385 0.92 ENSDART00000177231
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr22_-_22301672 0.89 ENSDART00000111711
chromatin assembly factor 1, subunit A (p150)
chr5_-_6567464 0.88 ENSDART00000184985
tankyrase 1 binding protein 1
chr2_+_48074243 0.85 ENSDART00000056291
Kruppel-like factor 6b
chr17_-_51195651 0.82 ENSDART00000191205
ENSDART00000088185
papilin a, proteoglycan-like sulfated glycoprotein
chr16_-_4769877 0.78 ENSDART00000149421
ENSDART00000054078
replication protein A2
chr6_-_33916756 0.77 ENSDART00000137447
ENSDART00000138488
nuclear autoantigenic sperm protein (histone-binding)
chr15_-_1485086 0.76 ENSDART00000191651
si:dkeyp-97b10.3
chr17_-_51199558 0.75 ENSDART00000154532
papilin a, proteoglycan-like sulfated glycoprotein
chr10_+_24627683 0.73 ENSDART00000112652
solute carrier family 46, member 3
chr20_+_53522059 0.72 ENSDART00000147570
p21 protein (Cdc42/Rac)-activated kinase 6b
chr23_+_17839187 0.71 ENSDART00000104647
DNA primase subunit 1
chr20_-_54869006 0.71 ENSDART00000184817

chr7_+_71586485 0.70 ENSDART00000165582
structural maintenance of chromosomes flexible hinge domain containing 1
chr23_+_45025909 0.70 ENSDART00000188105
high mobility group box 2b
chr13_-_35908275 0.69 ENSDART00000013961
MYCL proto-oncogene, bHLH transcription factor a
chr16_-_4770233 0.69 ENSDART00000193228
replication protein A2
chr4_-_2380173 0.68 ENSDART00000177727
nucleosome assembly protein 1-like 1
chr11_+_1551603 0.66 ENSDART00000185383
ENSDART00000121489
ENSDART00000040577
v-myb avian myeloblastosis viral oncogene homolog-like 2b
chr21_-_44731865 0.66 ENSDART00000013814
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 homolog (human)
chr16_+_53252951 0.65 ENSDART00000126543
si:ch211-269k10.5
chr14_-_22015232 0.64 ENSDART00000137795
structure specific recognition protein 1a
chr2_+_48073972 0.63 ENSDART00000186442
Kruppel-like factor 6b
chr7_-_16582187 0.63 ENSDART00000131726
E2F transcription factor 8
chr8_-_12403077 0.62 ENSDART00000142150
PHD finger protein 19
chr23_+_44049509 0.61 ENSDART00000102003
TXK tyrosine kinase
chr21_-_25213616 0.61 ENSDART00000122513
replication factor C (activator 1) 2
chr15_+_43333121 0.60 ENSDART00000161011
zgc:85932
chr1_-_7603734 0.60 ENSDART00000009315
myxovirus (influenza) resistance B
chr25_+_32390794 0.60 ENSDART00000012600
galactokinase 2
chr8_+_54013199 0.59 ENSDART00000158497

chr24_+_26328787 0.59 ENSDART00000003884
myoneurin
chr19_-_2582858 0.59 ENSDART00000113829
cell division cycle associated 7b
chr3_+_24537023 0.59 ENSDART00000077702
SP110 nuclear body protein, tandem duplicate 1
chr18_-_30499489 0.57 ENSDART00000033746
GINS complex subunit 2
chr1_-_59216197 0.56 ENSDART00000062426
lysophosphatidic acid receptor 2b
chr5_-_30535327 0.55 ENSDART00000040328
H2A histone family, member X
chr13_+_8255106 0.55 ENSDART00000080465
helicase, lymphoid specific
chr21_-_5393125 0.55 ENSDART00000146061
proteasome 26S subunit, non-ATPase 5
chr21_+_30721733 0.55 ENSDART00000040443
zgc:110224
chr5_-_67365750 0.55 ENSDART00000062359
uracil DNA glycosylase a
chr9_-_2892250 0.54 ENSDART00000140695
cell division cycle associated 7a
chr24_+_26329018 0.54 ENSDART00000145752
myoneurin
chr3_+_13332870 0.53 ENSDART00000113878

chr25_+_32496877 0.53 ENSDART00000132698
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2a
chr10_+_28428222 0.52 ENSDART00000135003
si:ch211-222e20.4
chr4_+_68776476 0.51 ENSDART00000169135
si:dkey-264f17.3
chr18_+_30421528 0.51 ENSDART00000140908
Gse1 coiled-coil protein
chr11_+_45153104 0.51 ENSDART00000159204
ENSDART00000177585
thymidine kinase 1, soluble
chr25_-_35124576 0.50 ENSDART00000128017
zgc:171759
chr3_+_24571163 0.49 ENSDART00000123017
SP110 nuclear body protein, tandem duplicate 3
chr6_-_6976096 0.49 ENSDART00000151822
ENSDART00000039443
ENSDART00000177960
tubulin, alpha 8 like 4
chr17_-_20236228 0.49 ENSDART00000136490
ENSDART00000029380
BCL2 interacting protein 4
chr23_-_36306337 0.48 ENSDART00000142760
ENSDART00000136929
ENSDART00000143340
chromobox homolog 5 (HP1 alpha homolog, Drosophila)
chr19_-_8748571 0.47 ENSDART00000031173
ribosomal protein S27, isoform 1
chr17_-_51199219 0.46 ENSDART00000154403
papilin a, proteoglycan-like sulfated glycoprotein
chr7_-_26306546 0.45 ENSDART00000140817
zgc:77439
chr7_+_24814866 0.45 ENSDART00000173581
si:ch211-226l4.6
chr21_-_23017478 0.45 ENSDART00000024309
retinoblastoma 1
chr11_-_45434959 0.45 ENSDART00000173106
ENSDART00000172767
ENSDART00000172933
ENSDART00000172986
replication factor C (activator 1) 4
chr15_-_1484795 0.45 ENSDART00000129356
si:dkeyp-97b10.3
chr18_-_8380090 0.44 ENSDART00000141581
ENSDART00000081143
selenophosphate synthetase 1
chr2_-_59285085 0.44 ENSDART00000131880
finTRIM family, member 34
chr10_-_15644904 0.44 ENSDART00000138389
ENSDART00000101191
ENSDART00000186559
ENSDART00000122170
structural maintenance of chromosomes 5
chr2_-_122154 0.43 ENSDART00000156248
ENSDART00000004071
zinc finger-like gene 2a
chr8_-_2504714 0.43 ENSDART00000171559
ribosomal protein L6
chr11_-_3308569 0.42 ENSDART00000036581
cyclin-dependent kinase 2
chr23_-_3758637 0.42 ENSDART00000131536
ENSDART00000139408
ENSDART00000137826
high mobility group AT-hook 1a
chr13_+_48358467 0.42 ENSDART00000171080
ENSDART00000162531
mutS homolog 6 (E. coli)
chr7_+_1550966 0.42 ENSDART00000177863
ENSDART00000126840
SPT16 homolog, facilitates chromatin remodeling subunit
chr13_+_41022502 0.41 ENSDART00000026808
dickkopf WNT signaling pathway inhibitor 1a
chr5_-_67365333 0.41 ENSDART00000133438
uracil DNA glycosylase a
chr16_-_12787029 0.41 ENSDART00000139916
forkhead box J2
chr13_+_42602406 0.41 ENSDART00000133388
ENSDART00000147996
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
chr6_+_112579 0.40 ENSDART00000034505
adaptor-related protein complex 1, mu 2 subunit
chr10_+_6010570 0.40 ENSDART00000190025
ENSDART00000163680
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr6_-_1762191 0.40 ENSDART00000167928
origin recognition complex, subunit 4
chr23_-_36305874 0.39 ENSDART00000147598
ENSDART00000146986
ENSDART00000086985
ENSDART00000133259
chromobox homolog 5 (HP1 alpha homolog, Drosophila)
chr18_+_17020967 0.39 ENSDART00000189168
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr18_+_20226843 0.39 ENSDART00000100632
transducin-like enhancer of split 3a
chr24_+_10413484 0.39 ENSDART00000111014
MYC proto-oncogene, bHLH transcription factor a
chr9_-_30555725 0.39 ENSDART00000079222
chromatin assembly factor 1, subunit B
chr19_+_25465025 0.38 ENSDART00000018553
replication protein A3
chr22_-_5655680 0.37 ENSDART00000159629
minichromosome maintenance complex component 2
chr2_-_59303338 0.37 ENSDART00000100987
ENSDART00000140840
finTRIM family, member 35
chr13_-_35907768 0.37 ENSDART00000147522
MYCL proto-oncogene, bHLH transcription factor a
chr3_-_12227359 0.37 ENSDART00000167356
transcription factor AP-4 (activating enhancer binding protein 4)
chr13_+_28785814 0.36 ENSDART00000039028
NSE4 homolog A, SMC5-SMC6 complex component
chr13_-_14929236 0.36 ENSDART00000020576
cell division cycle 25B
chr21_-_27413294 0.36 ENSDART00000131646
solute carrier family 29 (equilibrative nucleoside transporter), member 2
chr14_-_16775158 0.36 ENSDART00000113711
ENSDART00000144781
ENSDART00000160411
MRN complex interacting protein
chr5_-_67365006 0.34 ENSDART00000136116
uracil DNA glycosylase a
chr22_-_22301929 0.34 ENSDART00000142027
chromatin assembly factor 1, subunit A (p150)
chr3_+_34988670 0.33 ENSDART00000011319
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr1_+_27690 0.33 ENSDART00000162928
embryonic ectoderm development
chr12_-_4206869 0.33 ENSDART00000106572
si:dkey-32n7.9
chr23_+_36306539 0.32 ENSDART00000053267
heterogeneous nuclear ribonucleoprotein A1b
chr11_+_3308656 0.32 ENSDART00000082458
SAP domain containing ribonucleoprotein
chr25_+_35051656 0.32 ENSDART00000133379
histone cluster 2, H3c
chr25_+_36333993 0.31 ENSDART00000184379

chr22_+_3153876 0.31 ENSDART00000163327
ribosomal protein L36
chr22_-_15578402 0.30 ENSDART00000062986
hematopoietic SH2 domain containing
chr25_-_35136267 0.30 ENSDART00000109751
zgc:173585
chr4_-_18939338 0.30 ENSDART00000132081
ENSDART00000042250
RAP1B, member of RAS oncogene family
chr3_-_4552590 0.30 ENSDART00000043148
ENSDART00000132224
finTRIM family, member 43
chr3_+_43086548 0.29 ENSDART00000163579
si:dkey-43p13.5
chr7_-_6429031 0.29 ENSDART00000173413
zgc:112234
chr15_-_1822548 0.29 ENSDART00000082026
ENSDART00000180230
matrix metallopeptidase 28
chr3_-_45778123 0.29 ENSDART00000146211
H3 histone, family 3B.1
chr3_+_27027781 0.29 ENSDART00000065495
epithelial membrane protein 2
chr3_+_57825938 0.29 ENSDART00000128815
centromere protein X
chr3_-_45777226 0.28 ENSDART00000192849
H3 histone, family 3B.1
chr14_-_9420911 0.28 ENSDART00000081158
SH3 domain binding glutamate-rich protein like
chr3_+_13603272 0.28 ENSDART00000185084
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr23_+_44236855 0.28 ENSDART00000130147
ENSDART00000051907
si:ch1073-157b13.1
chr25_+_32496723 0.28 ENSDART00000087978
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2a
chr8_-_49766205 0.28 ENSDART00000137941
ENSDART00000097919
ENSDART00000147309
heterogeneous nuclear ribonucleoprotein K
chr10_+_10728870 0.28 ENSDART00000109282
SWI5 homologous recombination repair protein
chr9_-_56232296 0.28 ENSDART00000149554
ribosomal protein L31
chr21_+_1647990 0.27 ENSDART00000148540
ferrochelatase
chr17_-_15189397 0.26 ENSDART00000133710
ENSDART00000110507
WD repeat and HMG-box DNA binding protein 1
chr16_+_4770266 0.26 ENSDART00000038036
ubiquitin protein ligase E3D
chr9_-_54361357 0.26 ENSDART00000149813
RAD50 homolog, double strand break repair protein
chr3_-_8510201 0.26 ENSDART00000009151

chr6_-_51573975 0.26 ENSDART00000073865
retinoblastoma-like 1 (p107)
chr6_+_33931740 0.25 ENSDART00000130492
ENSDART00000151213
origin recognition complex, subunit 1
chr3_+_34846201 0.25 ENSDART00000055263
integrin, alpha 3a
chr5_+_24047292 0.25 ENSDART00000029889
CTD nuclear envelope phosphatase 1a
chr25_+_3549401 0.25 ENSDART00000166312
coiled-coil domain containing 77
chr8_-_20230559 0.24 ENSDART00000193677
MLLT1, super elongation complex subunit a
chr23_+_29358188 0.24 ENSDART00000189242
TAR DNA binding protein, like
chr3_-_16719244 0.24 ENSDART00000055859
polymerase (DNA directed), delta 1, catalytic subunit
chr7_+_73801377 0.24 ENSDART00000184051
si:ch73-252p3.1
chr25_-_36370292 0.23 ENSDART00000152766
Histone H2B 1/2
chr20_+_46427984 0.23 ENSDART00000060706
ENSDART00000143858
RAD51 recombinase
chr24_-_13349464 0.23 ENSDART00000134482
ENSDART00000139212
telomeric repeat binding factor (NIMA-interacting) 1
chr22_-_20419660 0.23 ENSDART00000105520
protein inhibitor of activated STAT, 4a
chr7_-_6351021 0.23 ENSDART00000159542
zgc:112234
chr3_-_14571514 0.22 ENSDART00000137197
SWIM-type zinc finger 7 associated protein 1
chr5_+_41477526 0.22 ENSDART00000153567
protein inhibitor of activated STAT, 2
chr22_+_24157807 0.22 ENSDART00000159165
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr6_-_42336987 0.22 ENSDART00000128777
ENSDART00000075601
Fanconi anemia, complementation group D2
chr7_-_6445129 0.22 ENSDART00000172825
Histone H3.2
chr6_+_22326624 0.22 ENSDART00000020333
ribonucleic acid export 1
chr2_+_32016256 0.21 ENSDART00000005143
MYC proto-oncogene, bHLH transcription factor b
chr7_+_55518519 0.21 ENSDART00000098476
ENSDART00000149915
chromatin licensing and DNA replication factor 1
chr2_-_57900430 0.21 ENSDART00000132245
ENSDART00000140060
si:dkeyp-68b7.7
chr20_+_13141408 0.21 ENSDART00000034098
denticleless E3 ubiquitin protein ligase homolog (Drosophila)
chr25_+_8447565 0.21 ENSDART00000142090
Fanconi anemia, complementation group I
chr20_-_36416922 0.21 ENSDART00000019145
lamin B receptor
chr19_-_11846958 0.21 ENSDART00000148516
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
chr24_+_11908480 0.21 ENSDART00000024224
flap structure-specific endonuclease 1
chr19_+_1873059 0.21 ENSDART00000145246
small nuclear ribonucleoprotein D1 polypeptide
chr8_+_48848200 0.21 ENSDART00000130673
tumor protein p73
chr24_+_11908833 0.20 ENSDART00000178622
flap structure-specific endonuclease 1
chr2_+_32016516 0.20 ENSDART00000135040
MYC proto-oncogene, bHLH transcription factor b
chr9_-_44983666 0.20 ENSDART00000149704
integrin, beta 2
chr1_+_14020445 0.20 ENSDART00000079716
histone PARylation factor 1
chr13_+_48359573 0.20 ENSDART00000161959
ENSDART00000165311
mutS homolog 6 (E. coli)
chr22_-_4439311 0.20 ENSDART00000169317
ubiquitin-like with PHD and ring finger domains 1
chr12_-_656540 0.20 ENSDART00000172651
sulfotransferase family 2, cytosolic sulfotransferase 2
chr15_+_37589698 0.20 ENSDART00000076066
ENSDART00000153894
ENSDART00000156298
lin-37 DREAM MuvB core complex component
chr4_-_42242844 0.20 ENSDART00000163476
si:ch211-129p6.2
chr12_+_17603528 0.19 ENSDART00000111565
PMS1 homolog 2, mismatch repair system component
chr7_+_41812636 0.19 ENSDART00000174333
origin recognition complex, subunit 6
chr1_+_49415281 0.19 ENSDART00000015007
TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr23_+_36340520 0.19 ENSDART00000011201
coatomer protein complex, subunit zeta 1
chr8_+_37749263 0.19 ENSDART00000108556
ENSDART00000147942
nucleophosmin/nucleoplasmin, 2a
chr7_+_57725708 0.19 ENSDART00000056466
ENSDART00000142259
ENSDART00000166198
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1
chr4_+_74943111 0.18 ENSDART00000004739
nucleoporin 50
chr14_+_26247319 0.18 ENSDART00000192793
coiled-coil domain containing 69
chr8_-_48847772 0.18 ENSDART00000122458
WD repeat containing, antisense to TP73
chr3_-_7897305 0.18 ENSDART00000169757
ubinuclein 2b
chr22_+_1911269 0.18 ENSDART00000164158
ENSDART00000168205
zinc finger protein 1156
chr6_-_13200585 0.18 ENSDART00000185321
eukaryotic translation elongation factor 1 beta 2
chr24_+_9693951 0.18 ENSDART00000082411
DNA topoisomerase II binding protein 1
chr6_-_9282080 0.18 ENSDART00000159506
coiled-coil domain containing 14

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f1_e2f7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.5 5.3 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.3 1.3 GO:0097510 base-excision repair, AP site formation via deaminated base removal(GO:0097510)
0.2 2.6 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.2 1.6 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.2 0.6 GO:0002566 somatic diversification of immune receptors via somatic mutation(GO:0002566) pyrimidine dimer repair(GO:0006290) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.2 1.3 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.2 0.7 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.2 0.5 GO:0009120 deoxyribonucleoside metabolic process(GO:0009120) thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.2 0.6 GO:0033301 cell cycle comprising mitosis without cytokinesis(GO:0033301)
0.1 0.4 GO:0051026 chiasma assembly(GO:0051026)
0.1 0.4 GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway(GO:0010142) isoprenoid biosynthetic process via mevalonate(GO:1902767)
0.1 0.1 GO:0009219 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211) pyrimidine deoxyribonucleotide metabolic process(GO:0009219)
0.1 0.6 GO:0000012 single strand break repair(GO:0000012)
0.1 0.8 GO:0044030 regulation of DNA methylation(GO:0044030)
0.1 1.0 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.1 0.6 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 0.4 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.1 0.3 GO:0003093 renal system process involved in regulation of blood volume(GO:0001977) renal system process involved in regulation of systemic arterial blood pressure(GO:0003071) regulation of glomerular filtration(GO:0003093)
0.1 0.4 GO:0045448 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.1 0.6 GO:0006012 galactose metabolic process(GO:0006012)
0.1 0.4 GO:0071320 negative regulation of neurotransmitter secretion(GO:0046929) response to cAMP(GO:0051591) cellular response to cAMP(GO:0071320) negative regulation of synaptic vesicle transport(GO:1902804) negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1 0.2 GO:0042148 strand invasion(GO:0042148)
0.1 0.7 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 0.4 GO:0001887 selenium compound metabolic process(GO:0001887)
0.1 0.2 GO:1990918 double-strand break repair involved in meiotic recombination(GO:1990918)
0.1 0.2 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.1 0.4 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.1 0.3 GO:1990697 protein depalmitoleylation(GO:1990697)
0.1 2.2 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)
0.1 0.2 GO:0043570 maintenance of DNA repeat elements(GO:0043570)
0.1 1.3 GO:0006270 DNA replication initiation(GO:0006270)
0.1 0.4 GO:0015864 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.0 0.2 GO:0010867 regulation of triglyceride biosynthetic process(GO:0010866) positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0 0.1 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228) protein localization to nuclear envelope(GO:0090435)
0.0 2.0 GO:0006289 nucleotide-excision repair(GO:0006289)
0.0 1.7 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.2 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.0 0.6 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.3 GO:0033260 nuclear DNA replication(GO:0033260)
0.0 0.2 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.0 0.2 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.4 GO:0061056 sclerotome development(GO:0061056)
0.0 0.4 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.0 0.5 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 0.1 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0 0.3 GO:0003160 endocardium morphogenesis(GO:0003160)
0.0 0.3 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 0.1 GO:1903003 regulation of protein deubiquitination(GO:0090085) positive regulation of protein deubiquitination(GO:1903003)
0.0 0.6 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.0 0.1 GO:0090579 establishment of mitotic sister chromatid cohesion(GO:0034087) establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169) transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.0 2.5 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.6 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.1 GO:0071042 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047)
0.0 1.6 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 0.3 GO:0006298 mismatch repair(GO:0006298)
0.0 0.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.1 GO:0034447 very-low-density lipoprotein particle clearance(GO:0034447)
0.0 0.1 GO:1901207 regulation of heart looping(GO:1901207)
0.0 0.4 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.4 GO:1990399 sensory epithelium regeneration(GO:0070654) epithelium regeneration(GO:1990399)
0.0 0.1 GO:0031053 primary miRNA processing(GO:0031053)
0.0 0.5 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.4 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)
0.0 0.9 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.0 0.3 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.4 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.1 GO:0000338 protein deneddylation(GO:0000338)
0.0 1.0 GO:0000724 double-strand break repair via homologous recombination(GO:0000724)
0.0 1.3 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.2 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.1 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.3 GO:1902807 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.5 GO:0048538 thymus development(GO:0048538)
0.0 0.8 GO:0006606 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.0 0.4 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 0.0 GO:0061187 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.0 0.2 GO:0031397 negative regulation of protein ubiquitination(GO:0031397)
0.0 0.1 GO:0032469 endoplasmic reticulum calcium ion homeostasis(GO:0032469)
0.0 0.4 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.1 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.0 0.5 GO:0006310 DNA recombination(GO:0006310)
0.0 0.2 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.6 GO:1902275 regulation of chromatin organization(GO:1902275)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.9 GO:0061702 inflammasome complex(GO:0061702)
0.4 1.6 GO:0033186 CAF-1 complex(GO:0033186)
0.4 2.0 GO:0005662 DNA replication factor A complex(GO:0005662)
0.3 1.6 GO:0000811 GINS complex(GO:0000811)
0.3 5.4 GO:0042555 MCM complex(GO:0042555)
0.3 1.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.2 0.7 GO:0032301 MutSalpha complex(GO:0032301)
0.2 0.7 GO:1990077 primosome complex(GO:1990077)
0.2 0.5 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.2 1.2 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.2 1.1 GO:0035101 FACT complex(GO:0035101)
0.2 1.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 0.8 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 0.6 GO:0030870 Mre11 complex(GO:0030870)
0.1 0.7 GO:0032300 mismatch repair complex(GO:0032300)
0.1 1.1 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 0.4 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 1.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.2 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 0.4 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.0 0.2 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.0 0.5 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.2 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.0 0.3 GO:0071005 U2-type precatalytic spliceosome(GO:0071005)
0.0 0.3 GO:0033061 DNA recombinase mediator complex(GO:0033061)
0.0 0.6 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.0 0.2 GO:0016589 NURF complex(GO:0016589)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.5 GO:0005657 replication fork(GO:0005657)
0.0 0.5 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) nuclear chromosome, telomeric region(GO:0000784)
0.0 0.1 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.0 0.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 1.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 4.9 GO:0000785 chromatin(GO:0000785)
0.0 0.1 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.1 GO:0000243 commitment complex(GO:0000243)
0.0 0.4 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.1 GO:0005784 Sec61 translocon complex(GO:0005784)
0.0 0.2 GO:1990391 DNA repair complex(GO:1990391)
0.0 1.1 GO:0005882 intermediate filament(GO:0005882)
0.0 0.5 GO:0008305 integrin complex(GO:0008305)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
0.4 2.6 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.3 3.0 GO:0043142 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) single-stranded DNA-dependent ATPase activity(GO:0043142)
0.2 0.7 GO:0032405 guanine/thymine mispair binding(GO:0032137) single base insertion or deletion binding(GO:0032138) single thymine insertion binding(GO:0032143) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357) mismatch repair complex binding(GO:0032404) MutLalpha complex binding(GO:0032405)
0.2 3.0 GO:0003688 DNA replication origin binding(GO:0003688)
0.2 0.6 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 0.4 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.1 0.4 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 1.9 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.1 1.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.1 GO:0032135 DNA insertion or deletion binding(GO:0032135)
0.1 0.7 GO:0048019 receptor antagonist activity(GO:0048019)
0.1 1.4 GO:0008301 DNA binding, bending(GO:0008301)
0.1 0.6 GO:0001217 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.1 1.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.5 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.1 0.7 GO:0030332 cyclin binding(GO:0030332)
0.1 0.3 GO:1990699 palmitoleyl hydrolase activity(GO:1990699)
0.1 0.4 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 1.3 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 0.7 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 0.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 1.6 GO:0031491 nucleosome binding(GO:0031491)
0.1 0.5 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.4 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.4 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.2 GO:0070513 death domain binding(GO:0070513)
0.0 0.2 GO:0019948 SUMO activating enzyme activity(GO:0019948)
0.0 0.6 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.3 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 2.3 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.4 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.2 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0 0.3 GO:0017091 AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.7 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 0.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.9 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.6 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.1 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.4 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.0 0.1 GO:0045735 nutrient reservoir activity(GO:0045735)
0.0 1.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 2.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.4 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.1 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 3.0 GO:0042393 histone binding(GO:0042393)
0.0 0.2 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.1 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.6 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.0 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.0 0.2 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 2.8 GO:0030246 carbohydrate binding(GO:0030246)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 8.9 PID E2F PATHWAY E2F transcription factor network
0.1 4.1 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.6 PID ATR PATHWAY ATR signaling pathway
0.0 0.4 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 2.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.2 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 1.2 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.5 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 0.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 6.9 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.4 1.9 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.2 4.4 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 0.7 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.1 0.4 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 3.0 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 1.3 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 1.4 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.1 1.0 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 2.7 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 0.9 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 0.2 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.3 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 1.0 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.4 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.3 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.6 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.1 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.3 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.6 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.4 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.2 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.4 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.2 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.2 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.5 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 0.6 REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21