ISMARA results: dlx2a+dlx2b

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PRJNA207719: Tissue specific transcriptome profiling

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Results for dlx2a+dlx2b_dlx4a+dlx4b+dlx6a

Z-value: 0.95

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Transcription factors associated with dlx2a+dlx2b_dlx4a+dlx4b+dlx6a

Gene Symbol	Gene ID	Gene Info
dlx2b NCBI UniProt	ENSDARG00000017174	distal-less homeobox 2b
dlx2a NCBI UniProt	ENSDARG00000079964	distal-less homeobox 2a
dlx2b NCBI UniProt	ENSDARG00000116017	distal-less homeobox 2b
dlx4a NCBI UniProt	ENSDARG00000011956	distal-less homeobox 4a
dlx6a NCBI UniProt	ENSDARG00000042291	distal-less homeobox 6a
dlx4b NCBI UniProt	ENSDARG00000071560	distal-less homeobox 4b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
dlx4b	dr11_v1_chr12_-_5728755_5728755	-0.79	1.1e-01	Click!
dlx4a	dr11_v1_chr3_+_34670076_34670076	-0.76	1.3e-01	Click!
dlx6a	dr11_v1_chr19_+_41419519_41419519	0.55	3.4e-01	Click!
dlx2a	dr11_v1_chr9_-_3400727_3400729	0.09	8.9e-01	Click!
dlx2b	dr11_v1_chr1_-_30979707_30979707	0.01	9.8e-01	Click!

Activity profile of dlx2a+dlx2b_dlx4a+dlx4b+dlx6a motif

Sorted Z-values of dlx2a+dlx2b_dlx4a+dlx4b+dlx6a motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr23_+_28731379 Show fit	1.03	ENSDART00000047378	cort NCBI UniProt Show fit	cortistatin
chr20_-_45060241 Show fit	0.76	ENSDART00000185227	klhl29 NCBI UniProt Show fit	kelch-like family member 29
chr12_+_24342303 Show fit	0.75	ENSDART00000111239	nrxn1a NCBI UniProt Show fit	neurexin 1a
chr24_-_24849091 Show fit	0.70	ENSDART00000133649 ENSDART00000038290	crhb NCBI UniProt Show fit	corticotropin releasing hormone b
chrM_+_9052 Show fit	0.68	ENSDART00000093612	mt-atp6 NCBI UniProt Show fit	ATP synthase 6, mitochondrial
chr17_-_20717845 Show fit	0.68	ENSDART00000150037	ank3b NCBI UniProt Show fit	ankyrin 3b
chr20_-_9462433 Show fit	0.68	ENSDART00000152674 ENSDART00000040557	zgc:101840 NCBI UniProt Show fit	zgc:101840
chr16_+_5774977 Show fit	0.68	ENSDART00000134202	ccka NCBI UniProt Show fit	cholecystokinin a
chr13_+_38430466 Show fit	0.66	ENSDART00000132691	adgrb3 NCBI UniProt Show fit	adhesion G protein-coupled receptor B3
chr20_-_28800999 Show fit	0.62	ENSDART00000049462	rab15 NCBI UniProt Show fit	RAB15, member RAS oncogene family

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of dlx2a+dlx2b_dlx4a+dlx4b+dlx6a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.9	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0	0.9	GO:0003009	skeletal muscle contraction(GO:0003009)
0.1	0.8	GO:1904071	presynaptic active zone assembly(GO:1904071)
0.2	0.7	GO:0035902	response to immobilization stress(GO:0035902)
0.1	0.7	GO:0016322	neuron remodeling(GO:0016322)
0.0	0.7	GO:0015986	energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0	0.7	GO:0070593	dendrite self-avoidance(GO:0070593)
0.0	0.7	GO:0007586	digestion(GO:0007586)
0.1	0.6	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0	0.6	GO:0001574	ganglioside biosynthetic process(GO:0001574)

Showing 1 to 10 of 57 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	GO:1990246	uniplex complex(GO:1990246)
0.0	0.9	GO:0005861	troponin complex(GO:0005861)
0.1	0.8	GO:0098982	GABA-ergic synapse(GO:0098982)
0.1	0.7	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.7	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0	0.7	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.1	0.6	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1	0.6	GO:0032593	insulin-responsive compartment(GO:0032593)
0.1	0.5	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
0.0	0.4	GO:0032591	dendritic spine membrane(GO:0032591)

Showing 1 to 10 of 18 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.3	GO:0005179	hormone activity(GO:0005179)
0.0	1.0	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	0.8	GO:0098882	structural constituent of presynaptic active zone(GO:0098882)
0.0	0.7	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.7	GO:0098632	protein binding involved in cell-cell adhesion(GO:0098632)
0.0	0.7	GO:0005184	neuropeptide hormone activity(GO:0005184)
0.1	0.6	GO:0016316	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.0	0.6	GO:0001540	beta-amyloid binding(GO:0001540)
0.0	0.6	GO:0008376	acetylgalactosaminyltransferase activity(GO:0008376)
0.1	0.5	GO:0048763	ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)

Showing 1 to 10 of 41 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	0.2	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway

Showing 1 to 2 of 2 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	0.4	REACTOME KERATAN SULFATE BIOSYNTHESIS	Genes involved in Keratan sulfate biosynthesis
0.0	0.3	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.3	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	0.2	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.0	0.2	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.1	REACTOME ACYL CHAIN REMODELLING OF PG	Genes involved in Acyl chain remodelling of PG

Showing 1 to 7 of 7 entries

Results for dlx2a+dlx2b_dlx4a+dlx4b+dlx6a

Z-value: 0.95

Motif logo

Transcription factors associated with dlx2a+dlx2b_dlx4a+dlx4b+dlx6a

Activity-expression correlation:

Activity profile of dlx2a+dlx2b_dlx4a+dlx4b+dlx6a motif

Sorted Z-values of dlx2a+dlx2b_dlx4a+dlx4b+dlx6a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of dlx2a+dlx2b_dlx4a+dlx4b+dlx6a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: