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PRJNA207719: Tissue specific transcriptome profiling
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Results for dlx1a
Z-value: 1.61
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Transcription factors associated with dlx1a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| dlx1a | dr11_v1_chr9_+_3388099_3388099 | -0.87 | 5.6e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_+_22580579 Show fit | 1.08 |
ENSDART00000171725
ENSDART00000192290 |
capping protein (actin filament), gelsolin-like b |
|
| chr22_+_11775269 Show fit | 1.08 |
ENSDART00000140272
|
keratin 96 |
|
| chr24_-_27452488 Show fit | 1.07 |
ENSDART00000136433
|
chemokine (C-C motif) ligand 34b, duplicate 8 |
|
| chr23_+_4689626 Show fit | 0.99 |
ENSDART00000131532
|
glycoprotein IX (platelet) |
|
| chr3_-_59297532 Show fit | 0.98 |
ENSDART00000187991
|
|
|
| chr21_-_42876565 Show fit | 0.97 |
ENSDART00000126480
|
zmp:0000001268 |
|
| chr23_+_20110086 Show fit | 0.94 |
ENSDART00000054664
|
troponin C type 1b (slow) |
|
| chr20_-_37813863 Show fit | 0.93 |
ENSDART00000147529
|
basic leucine zipper transcription factor, ATF-like 3 |
|
| chr18_+_5490668 Show fit | 0.93 |
ENSDART00000167035
|
muscle-specific beta 1 integrin binding protein 2 |
|
| chr19_-_5358443 Show fit | 0.84 |
ENSDART00000105036
|
type I cytokeratin, enveloping layer, like |
Network of associatons between targets according to the STRING database.
First level regulatory network of dlx1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.0 | 2.5 | GO:0070098 | chemokine-mediated signaling pathway(GO:0070098) |
| 0.0 | 1.4 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 0.0 | 1.1 | GO:0055008 | cardiac muscle tissue morphogenesis(GO:0055008) |
| 0.0 | 1.1 | GO:0051014 | actin filament severing(GO:0051014) |
| 0.0 | 1.0 | GO:0006446 | regulation of translational initiation(GO:0006446) |
| 0.0 | 1.0 | GO:0007044 | cell-substrate junction assembly(GO:0007044) |
| 0.0 | 0.9 | GO:1990266 | neutrophil migration(GO:1990266) |
| 0.2 | 0.8 | GO:0036462 | TRAIL-activated apoptotic signaling pathway(GO:0036462) |
| 0.1 | 0.8 | GO:0030216 | keratinocyte differentiation(GO:0030216) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 2.9 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 2.6 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 1.5 | GO:0022626 | cytosolic large ribosomal subunit(GO:0022625) cytosolic ribosome(GO:0022626) |
| 0.0 | 1.3 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 1.2 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 1.0 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 0.8 | GO:0043186 | P granule(GO:0043186) |
| 0.0 | 0.8 | GO:0005901 | caveola(GO:0005901) plasma membrane raft(GO:0044853) |
| 0.1 | 0.7 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 2.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 2.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 1.9 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 1.8 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 1.8 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.3 | 1.3 | GO:0009374 | biotin binding(GO:0009374) |
| 0.0 | 1.3 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.2 | 1.2 | GO:0050262 | ribosylnicotinamide kinase activity(GO:0050262) |
| 0.1 | 1.2 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.0 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 0.9 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.9 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 0.8 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 0.8 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 0.7 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.6 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 0.6 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 0.5 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 2.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 1.2 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 1.0 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 0.8 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 0.7 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 0.7 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 0.7 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.6 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 0.6 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |