ISMARA results: ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4

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PRJNA207719: Tissue specific transcriptome profiling

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Results for ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4

Z-value: 1.76

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Transcription factors associated with ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4

Gene Symbol	Gene ID	Gene Info
nfatc1 NCBI UniProt	ENSDARG00000036168	nuclear factor of activated T cells 1
nfatc3b NCBI UniProt	ENSDARG00000051729	nuclear factor of activated T cells 3b
nfatc4 NCBI UniProt	ENSDARG00000054162	nuclear factor of activated T cells 4
nfatc3a NCBI UniProt	ENSDARG00000076297	nuclear factor of activated T cells 3a
nfatc2b NCBI UniProt	ENSDARG00000079972	nuclear factor of activated T cells 2b
ddx28 NCBI UniProt	ENSDARG00000112133	nuclear factor of activated T cells 3a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
nfatc1	dr11_v1_chr19_+_22216778_22216778	0.94	1.9e-02	Click!
nfatc2b	dr11_v1_chr6_-_55254786_55254786	-0.39	5.1e-01	Click!
nfatc3b	dr11_v1_chr25_-_36248053_36248053	0.32	5.9e-01	Click!
nfatc3a	dr11_v1_chr7_-_34927961_34927961	0.30	6.3e-01	Click!
nfatc4	dr11_v1_chr2_-_37797577_37797577	0.13	8.3e-01	Click!

Activity profile of ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4 motif

Sorted Z-values of ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_26064480 Show fit	1.46	ENSDART00000158215 ENSDART00000171206 ENSDART00000171212 ENSDART00000182956 ENSDART00000186779	ldb3b NCBI UniProt Show fit	LIM domain binding 3b
chr13_+_23157053 Show fit	1.45	ENSDART00000162359	sorbs1 NCBI UniProt Show fit	sorbin and SH3 domain containing 1
chr15_-_20933574 Show fit	1.17	ENSDART00000152648 ENSDART00000152448 ENSDART00000152244	usp2a NCBI UniProt Show fit	ubiquitin specific peptidase 2a
chr18_+_26743749 Show fit	1.13	ENSDART00000145212	alpk3a NCBI UniProt Show fit	alpha-kinase 3a
chr1_-_38816685 Show fit	1.09	ENSDART00000075230	asb5b NCBI UniProt Show fit	ankyrin repeat and SOCS box containing 5b
chr2_-_24289641 Show fit	0.97	ENSDART00000128784 ENSDART00000123565 ENSDART00000141922 ENSDART00000184550 ENSDART00000191469	myh7l NCBI UniProt Show fit	myosin heavy chain 7-like
chr6_-_10233538 Show fit	0.95	ENSDART00000182004 ENSDART00000149237 ENSDART00000148876	xirp2a NCBI UniProt Show fit	xin actin binding repeat containing 2a
chr22_-_15587360 Show fit	0.89	ENSDART00000142717 ENSDART00000138978	tpm4a NCBI UniProt Show fit	tropomyosin 4a
chr14_+_49296052 Show fit	0.86	ENSDART00000006073 ENSDART00000105346	anxa6 NCBI UniProt Show fit	annexin A6
chr3_-_39152478 Show fit	0.85	ENSDART00000154550	si:dkeyp-57f11.2 NCBI UniProt Show fit	si:dkeyp-57f11.2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.0	GO:0010842	retina layer formation(GO:0010842)
0.1	1.8	GO:0098703	calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.2	1.3	GO:0055014	atrial cardiac muscle cell development(GO:0055014)
0.0	1.3	GO:0010906	regulation of glucose metabolic process(GO:0010906)
0.1	1.2	GO:0055003	cardiac myofibril assembly(GO:0055003)
0.0	1.2	GO:0030834	regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835)
0.2	0.9	GO:0003413	plasma membrane repair(GO:0001778) chondrocyte differentiation involved in endochondral bone morphogenesis(GO:0003413) growth plate cartilage chondrocyte differentiation(GO:0003418)
0.1	0.8	GO:0071908	determination of intestine left/right asymmetry(GO:0071908)
0.1	0.8	GO:0061026	cardiac muscle tissue regeneration(GO:0061026)
0.0	0.8	GO:0048769	sarcomerogenesis(GO:0048769)

Showing 1 to 10 of 69 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.2	GO:0042383	sarcolemma(GO:0042383)
0.0	1.8	GO:0031941	filamentous actin(GO:0031941)
0.0	1.8	GO:0016459	myosin complex(GO:0016459)
0.0	1.7	GO:0030018	Z disc(GO:0030018)
0.0	1.6	GO:0030017	sarcomere(GO:0030017)
0.0	1.0	GO:0031430	M band(GO:0031430)
0.0	0.8	GO:0005814	centriole(GO:0005814)
0.2	0.7	GO:1990111	spermatoproteasome complex(GO:1990111)
0.0	0.7	GO:0005869	dynactin complex(GO:0005869)
0.0	0.6	GO:0000164	protein phosphatase type 1 complex(GO:0000164)

Showing 1 to 10 of 23 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.8	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.1	1.5	GO:0051393	muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.0	0.9	GO:0001786	phosphatidylserine binding(GO:0001786)
0.0	0.8	GO:0008307	structural constituent of muscle(GO:0008307)
0.0	0.8	GO:0017147	Wnt-protein binding(GO:0017147)
0.1	0.7	GO:0043914	NADPH:sulfur oxidoreductase activity(GO:0043914)
0.1	0.7	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1	0.7	GO:0016504	peptidase activator activity(GO:0016504)
0.0	0.7	GO:0031545	peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.6	GO:2001069	glycogen binding(GO:2001069)

Showing 1 to 10 of 49 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
1.4	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.6	NABA COLLAGENS	Genes encoding collagen proteins
0.5	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.4	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.3	PID NECTIN PATHWAY	Nectin adhesion pathway
0.3	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.2	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.2	PID S1P S1P2 PATHWAY	S1P2 pathway

Showing 1 to 8 of 8 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.5	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	1.2	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.6	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.5	REACTOME MUSCLE CONTRACTION	Genes involved in Muscle contraction
0.1	0.4	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.0	0.4	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.4	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.2	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	0.2	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins

Showing 1 to 10 of 12 entries

Results for ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4

Z-value: 1.76

Motif logo

Transcription factors associated with ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4

Activity-expression correlation:

Activity profile of ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4 motif

Sorted Z-values of ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: