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PRJNA207719: Tissue specific transcriptome profiling
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Results for dbpa+dbpb+hlfa
Z-value: 1.07
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Transcription factors associated with dbpa+dbpb+hlfa
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000057652 | D site albumin promoter binding protein b | |
| ENSDARG00000063014 | D site albumin promoter binding protein a | |
| ENSDARG00000074752 | HLF transcription factor, PAR bZIP family member a | |
| ENSDARG00000116703 | D site albumin promoter binding protein b |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| dbpb | dr11_v1_chr16_-_13612650_13612650 | 0.95 | 1.5e-02 | Click! |
| hlfa | dr11_v1_chr3_-_11624694_11624694 | 0.93 | 2.3e-02 | Click! |
| dbpa | dr11_v1_chr19_-_10196370_10196370 | 0.92 | 2.8e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr24_-_38079261 Show fit | 1.68 |
ENSDART00000105662
|
C-reactive protein 1 |
|
| chr16_+_34523515 Show fit | 1.48 |
ENSDART00000041007
|
stathmin 1b |
|
| chr21_-_43550120 Show fit | 1.32 |
ENSDART00000151627
|
si:ch73-362m14.2 |
|
| chr2_-_54387550 Show fit | 1.31 |
ENSDART00000097388
|
N-ethylmaleimide-sensitive factor attachment protein, gamma b |
|
| chr3_-_46818001 Show fit | 1.26 |
ENSDART00000166505
|
ELAV like neuron-specific RNA binding protein 3 |
|
| chr3_-_28665291 Show fit | 1.21 |
ENSDART00000151670
|
F-box and leucine-rich repeat protein 16 |
|
| chr23_-_27345425 Show fit | 1.11 |
ENSDART00000022042
ENSDART00000191870 |
sodium channel, voltage gated, type VIII, alpha subunit a |
|
| chr8_+_28900689 Show fit | 1.07 |
ENSDART00000141634
|
glutamate receptor, ionotropic, delta 2 |
|
| chr1_+_31112436 Show fit | 1.00 |
ENSDART00000075340
|
eukaryotic translation elongation factor 1 alpha 1b |
|
| chr12_-_26383242 Show fit | 0.99 |
ENSDART00000152941
|
ubiquitin specific peptidase 54b |
Network of associatons between targets according to the STRING database.
First level regulatory network of dbpa+dbpb+hlfa
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.3 | 1.1 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 0.1 | 1.1 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.0 | 1.1 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.0 | 1.1 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.1 | 1.0 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
| 0.0 | 1.0 | GO:0006414 | translational elongation(GO:0006414) |
| 0.0 | 0.9 | GO:0014059 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 0.1 | 0.7 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.1 | 0.7 | GO:1990504 | dense core granule exocytosis(GO:1990504) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 1.4 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 1.1 | GO:0034706 | voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706) |
| 0.0 | 0.9 | GO:1902711 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
| 0.0 | 0.9 | GO:0098978 | glutamatergic synapse(GO:0098978) |
| 0.0 | 0.7 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.2 | 0.6 | GO:0070044 | synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044) |
| 0.0 | 0.6 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.1 | 0.5 | GO:0033010 | paranodal junction(GO:0033010) |
| 0.0 | 0.4 | GO:0044666 | MLL3/4 complex(GO:0044666) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.0 | GO:0005483 | soluble NSF attachment protein activity(GO:0005483) |
| 0.0 | 1.5 | GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 0.0 | 1.4 | GO:0036459 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.0 | 1.1 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.0 | 1.1 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.1 | 1.0 | GO:0016880 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
| 0.0 | 1.0 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.1 | 0.7 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.0 | 0.7 | GO:0051721 | protein phosphatase 2A binding(GO:0051721) |
| 0.2 | 0.6 | GO:0072590 | N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590) citrate-L-glutamate ligase activity(GO:0072591) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 0.9 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 0.6 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 0.3 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 0.3 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 0.2 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.0 | 0.8 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.0 | 0.6 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.0 | 0.4 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.0 | 0.4 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 0.4 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.3 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 0.3 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.3 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 0.2 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |