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PRJNA207719: Tissue specific transcriptome profiling
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Results for cux2b
Z-value: 1.40
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Transcription factors associated with cux2b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| cux2b | dr11_v1_chr8_-_4327473_4327473 | -0.91 | 3.1e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_21376290 Show fit | 1.74 |
ENSDART00000136765
|
elastase 2 |
|
| chr8_-_21372446 Show fit | 1.29 |
ENSDART00000061481
ENSDART00000079293 |
elastase 2 like |
|
| chr10_+_2715548 Show fit | 1.13 |
ENSDART00000130793
|
G protein-coupled receptor kinase 5 |
|
| chr1_-_52447364 Show fit | 1.11 |
ENSDART00000140740
|
si:ch211-217k17.10 |
|
| chr21_+_5531138 Show fit | 1.05 |
ENSDART00000163825
|
lymphocyte antigen 6 family member M6 |
|
| chr23_-_10175898 Show fit | 1.02 |
ENSDART00000146185
|
keratin 5 |
|
| chr17_-_51651631 Show fit | 0.89 |
ENSDART00000154699
|
chemokine (C-C motif) receptor 6b |
|
| chr11_-_18253111 Show fit | 0.87 |
ENSDART00000125984
|
musculoskeletal, embryonic nuclear protein 1b |
|
| chr23_+_32039386 Show fit | 0.82 |
ENSDART00000133801
|
myosin light chain kinase 2 |
|
| chr13_+_24402406 Show fit | 0.80 |
ENSDART00000043002
|
RAB1A, member RAS oncogene family b |
Network of associatons between targets according to the STRING database.
First level regulatory network of cux2b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.3 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.0 | 1.3 | GO:0042742 | defense response to bacterium(GO:0042742) |
| 0.0 | 1.3 | GO:0019722 | calcium-mediated signaling(GO:0019722) |
| 0.0 | 1.2 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
| 0.0 | 1.1 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
| 0.3 | 1.0 | GO:0033301 | cell cycle comprising mitosis without cytokinesis(GO:0033301) |
| 0.1 | 1.0 | GO:0044854 | membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836) |
| 0.0 | 1.0 | GO:0033627 | cell adhesion mediated by integrin(GO:0033627) |
| 0.0 | 1.0 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 0.0 | 1.0 | GO:0006414 | translational elongation(GO:0006414) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.4 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 2.4 | GO:0005840 | ribosome(GO:0005840) |
| 0.0 | 1.7 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.1 | 1.0 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 1.0 | GO:0044853 | caveola(GO:0005901) plasma membrane raft(GO:0044853) |
| 0.3 | 0.8 | GO:0034685 | integrin alphav-beta6 complex(GO:0034685) |
| 0.1 | 0.7 | GO:0035101 | FACT complex(GO:0035101) |
| 0.0 | 0.7 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.0 | 0.7 | GO:0005657 | replication fork(GO:0005657) |
| 0.0 | 0.6 | GO:0000815 | ESCRT III complex(GO:0000815) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 2.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 1.7 | GO:0019957 | C-C chemokine binding(GO:0019957) |
| 0.0 | 1.4 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 1.3 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.1 | 1.1 | GO:0004703 | G-protein coupled receptor kinase activity(GO:0004703) |
| 0.1 | 1.0 | GO:0001130 | bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217) |
| 0.0 | 1.0 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.0 | 1.0 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.1 | 0.9 | GO:0035804 | structural constituent of egg coat(GO:0035804) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 1.6 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 1.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 1.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.0 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 0.8 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.8 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.8 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 0.7 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.5 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 0.9 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.0 | 0.8 | REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 | Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| 0.0 | 0.8 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 0.7 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.2 | 0.6 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.0 | 0.6 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.0 | 0.6 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 0.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 0.5 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |