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PRJNA207719: Tissue specific transcriptome profiling
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Results for crx+otx1
Z-value: 0.95
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Transcription factors associated with crx+otx1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| otx1 | dr11_v1_chr17_+_24318753_24318753 | 0.32 | 6.0e-01 | Click! |
| crx | dr11_v1_chr5_+_36932718_36932718 | -0.22 | 7.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_3366782 Show fit | 0.53 |
ENSDART00000127982
|
sulfite oxidase |
|
| chr10_+_17026870 Show fit | 0.47 |
ENSDART00000184529
ENSDART00000157480 |
|
|
| chr16_-_46579936 Show fit | 0.46 |
ENSDART00000166143
ENSDART00000127212 |
si:dkey-152b24.6 |
|
| chr15_+_46605482 Show fit | 0.41 |
ENSDART00000184449
|
|
|
| chr24_-_21689146 Show fit | 0.39 |
ENSDART00000105917
|
ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase |
|
| chr16_-_16701718 Show fit | 0.37 |
ENSDART00000143550
|
si:dkey-8k3.2 |
|
| chr13_+_733027 Show fit | 0.37 |
ENSDART00000149547
|
neurexin 1b |
|
| chr9_-_3519253 Show fit | 0.34 |
ENSDART00000169586
|
ddb1 and cul4 associated factor 17 |
|
| chr22_-_16154771 Show fit | 0.34 |
ENSDART00000009464
|
solute carrier family 30 (zinc transporter), member 7 |
|
| chr22_+_25453334 Show fit | 0.33 |
ENSDART00000123962
|
si:ch211-12h2.6 |
Network of associatons between targets according to the STRING database.
First level regulatory network of crx+otx1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0046415 | urate catabolic process(GO:0019628) urate metabolic process(GO:0046415) |
| 0.0 | 0.3 | GO:0034433 | steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435) |
| 0.0 | 0.3 | GO:0009712 | catecholamine metabolic process(GO:0006584) catechol-containing compound metabolic process(GO:0009712) |
| 0.0 | 0.3 | GO:0030497 | fatty acid elongation(GO:0030497) |
| 0.0 | 0.3 | GO:0006829 | zinc II ion transport(GO:0006829) |
| 0.1 | 0.2 | GO:0031120 | snRNA pseudouridine synthesis(GO:0031120) |
| 0.0 | 0.2 | GO:0071260 | cellular response to mechanical stimulus(GO:0071260) |
| 0.0 | 0.2 | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162) |
| 0.0 | 0.1 | GO:0098967 | exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967) |
| 0.0 | 0.1 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 0.2 | GO:0072588 | box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) |
| 0.0 | 0.2 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.0 | 0.2 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.0 | 0.1 | GO:0034457 | Mpp10 complex(GO:0034457) |
| 0.0 | 0.1 | GO:0070195 | growth hormone receptor complex(GO:0070195) |
| 0.0 | 0.1 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 0.1 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.0 | 0.1 | GO:0031258 | lamellipodium membrane(GO:0031258) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:0016670 | oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) |
| 0.1 | 0.3 | GO:0102344 | 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345) |
| 0.1 | 0.3 | GO:0034736 | sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736) |
| 0.0 | 0.3 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.0 | 0.3 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.2 | GO:0000033 | alpha-1,3-mannosyltransferase activity(GO:0000033) |
| 0.0 | 0.2 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.0 | 0.1 | GO:0016427 | tRNA (cytosine) methyltransferase activity(GO:0016427) |
| 0.0 | 0.1 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
| 0.0 | 0.1 | GO:0038046 | enkephalin receptor activity(GO:0038046) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 0.3 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 0.2 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 0.2 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.0 | 0.1 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |