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PRJNA207719: Tissue specific transcriptome profiling
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Results for creb3l2
Z-value: 0.76
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Transcription factors associated with creb3l2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| creb3l2 | dr11_v1_chr4_-_4751981_4751983 | -0.31 | 6.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr23_-_10175898 Show fit | 1.15 |
ENSDART00000146185
|
keratin 5 |
|
| chr16_-_45178430 Show fit | 0.88 |
ENSDART00000165186
|
si:dkey-33i11.9 |
|
| chr16_+_49249669 Show fit | 0.79 |
ENSDART00000181899
|
|
|
| chr2_+_50999675 Show fit | 0.75 |
ENSDART00000158064
ENSDART00000165746 ENSDART00000163917 ENSDART00000172038 ENSDART00000169048 ENSDART00000164775 |
eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein) |
|
| chr3_-_55092051 Show fit | 0.71 |
ENSDART00000053077
|
hemoglobin, beta adult 2 |
|
| chr2_+_50999477 Show fit | 0.64 |
ENSDART00000190111
|
eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein) |
|
| chr2_+_39618951 Show fit | 0.60 |
ENSDART00000077108
|
zgc:136870 |
|
| chr18_+_7553950 Show fit | 0.59 |
ENSDART00000193420
ENSDART00000062143 |
zgc:77650 |
|
| chr8_+_44783424 Show fit | 0.51 |
ENSDART00000025875
|
si:ch1073-459j12.1 |
|
| chr5_-_1962500 Show fit | 0.50 |
ENSDART00000150163
|
ribosomal protein, large, P0 |
Network of associatons between targets according to the STRING database.
First level regulatory network of creb3l2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0006414 | translational elongation(GO:0006414) |
| 0.0 | 1.2 | GO:0031101 | fin regeneration(GO:0031101) |
| 0.0 | 0.7 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.1 | 0.6 | GO:0007080 | mitotic metaphase plate congression(GO:0007080) |
| 0.0 | 0.5 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.1 | 0.4 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.1 | 0.4 | GO:1904353 | positive regulation of telomere maintenance(GO:0032206) regulation of telomere capping(GO:1904353) positive regulation of telomere capping(GO:1904355) |
| 0.0 | 0.4 | GO:0070309 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059) lens fiber cell development(GO:0070307) lens fiber cell morphogenesis(GO:0070309) |
| 0.0 | 0.4 | GO:1902299 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299) |
| 0.0 | 0.4 | GO:0045454 | cell redox homeostasis(GO:0045454) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.4 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.1 | 1.1 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 0.8 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 0.7 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.2 | 0.6 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.1 | 0.4 | GO:0071065 | alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065) |
| 0.1 | 0.4 | GO:0097224 | sperm connecting piece(GO:0097224) |
| 0.0 | 0.4 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.0 | 0.4 | GO:1990589 | ATF4-CREB1 transcription factor complex(GO:1990589) |
| 0.0 | 0.4 | GO:0005839 | proteasome core complex(GO:0005839) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.1 | 0.7 | GO:0031720 | haptoglobin binding(GO:0031720) |
| 0.1 | 0.5 | GO:0070180 | large ribosomal subunit rRNA binding(GO:0070180) |
| 0.1 | 0.4 | GO:0008397 | sterol 12-alpha-hydroxylase activity(GO:0008397) |
| 0.1 | 0.4 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 0.1 | 0.4 | GO:0004365 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
| 0.1 | 0.4 | GO:0043140 | ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518) |
| 0.1 | 0.4 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 0.4 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) |
| 0.1 | 0.2 | GO:0004422 | hypoxanthine phosphoribosyltransferase activity(GO:0004422) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 0.3 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.0 | 0.1 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.6 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.0 | 0.4 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.0 | 0.4 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.4 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.0 | 0.3 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 0.3 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 0.3 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 0.3 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 0.1 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.0 | 0.1 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |