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PRJNA207719: Tissue specific transcriptome profiling
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Results for cdx1a+cdx1b
Z-value: 0.75
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Transcription factors associated with cdx1a+cdx1b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| cdx1b | dr11_v1_chr21_-_43992027_43992027 | -0.34 | 5.8e-01 | Click! |
| cdx1a | dr11_v1_chr14_+_3287740_3287740 | -0.08 | 9.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_15171435 Show fit | 0.83 |
ENSDART00000159148
ENSDART00000166622 |
si:dkey-77g12.1 |
|
| chr24_+_39105051 Show fit | 0.64 |
ENSDART00000115297
|
MSS51 mitochondrial translational activator |
|
| chr13_-_36034582 Show fit | 0.60 |
ENSDART00000133565
|
si:dkey-157l19.2 |
|
| chr14_+_15495088 Show fit | 0.57 |
ENSDART00000165765
ENSDART00000188577 |
si:dkey-203a12.6 |
|
| chr11_-_25257595 Show fit | 0.53 |
ENSDART00000123567
|
snail family zinc finger 1a |
|
| chr11_-_25257045 Show fit | 0.52 |
ENSDART00000130477
|
snail family zinc finger 1a |
|
| chr23_+_36115541 Show fit | 0.50 |
ENSDART00000130090
|
homeobox C6a |
|
| chr1_-_7603734 Show fit | 0.49 |
ENSDART00000009315
|
myxovirus (influenza) resistance B |
|
| chr23_+_7379728 Show fit | 0.49 |
ENSDART00000012194
|
GATA binding protein 5 |
|
| chr24_-_10014512 Show fit | 0.48 |
ENSDART00000124341
ENSDART00000191630 |
zgc:171474 |
Network of associatons between targets according to the STRING database.
First level regulatory network of cdx1a+cdx1b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | GO:0008078 | mesodermal cell migration(GO:0008078) |
| 0.2 | 0.5 | GO:0022009 | central nervous system vasculogenesis(GO:0022009) |
| 0.1 | 0.5 | GO:0048618 | post-embryonic foregut morphogenesis(GO:0048618) |
| 0.0 | 0.5 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 0.1 | 0.4 | GO:0002184 | cytoplasmic translational termination(GO:0002184) |
| 0.1 | 0.4 | GO:0051148 | smooth muscle cell differentiation(GO:0051145) negative regulation of muscle cell differentiation(GO:0051148) |
| 0.0 | 0.4 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.0 | 0.4 | GO:0033627 | cell adhesion mediated by integrin(GO:0033627) |
| 0.1 | 0.3 | GO:0033313 | meiotic cell cycle checkpoint(GO:0033313) |
| 0.1 | 0.3 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.5 | GO:1990909 | Wnt signalosome(GO:1990909) |
| 0.1 | 0.5 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.0 | 0.5 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 0.4 | GO:0018444 | translation release factor complex(GO:0018444) |
| 0.0 | 0.3 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.1 | 0.2 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
| 0.0 | 0.2 | GO:0044609 | DBIRD complex(GO:0044609) |
| 0.0 | 0.2 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 0.2 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.0 | 0.2 | GO:0034715 | pICln-Sm protein complex(GO:0034715) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.1 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.1 | 0.5 | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.0 | 0.5 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.1 | 0.4 | GO:0070180 | large ribosomal subunit rRNA binding(GO:0070180) |
| 0.1 | 0.3 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 0.0 | 0.3 | GO:0071916 | dipeptide transporter activity(GO:0042936) dipeptide transmembrane transporter activity(GO:0071916) |
| 0.0 | 0.3 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.0 | 0.3 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) |
| 0.0 | 0.3 | GO:0045159 | myosin II binding(GO:0045159) |
| 0.0 | 0.3 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 0.5 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.4 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 0.3 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 0.3 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.0 | 0.2 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.0 | 0.2 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 0.2 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.0 | 0.2 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.0 | 0.2 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |