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PRJNA207719: Tissue specific transcriptome profiling
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Results for cdc5l
Z-value: 1.94
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Transcription factors associated with cdc5l
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| cdc5l | dr11_v1_chr17_+_5061135_5061135 | -0.00 | 1.0e+00 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_+_33606739 Show fit | 2.05 |
ENSDART00000026464
|
cofilin 1 (non-muscle), like |
|
| chr19_-_31372896 Show fit | 2.04 |
ENSDART00000046609
|
scinderin |
|
| chr16_-_25085327 Show fit | 1.99 |
ENSDART00000077661
|
protease, serine 1 |
|
| chr1_-_45177373 Show fit | 1.37 |
ENSDART00000143142
ENSDART00000034549 |
zgc:111983 |
|
| chr18_+_7591381 Show fit | 1.34 |
ENSDART00000136313
|
si:dkeyp-1h4.6 |
|
| chr6_-_49063085 Show fit | 1.26 |
ENSDART00000156124
|
si:ch211-105j21.9 |
|
| chr22_+_7439186 Show fit | 1.23 |
ENSDART00000190667
|
zgc:92041 |
|
| chr10_+_2669405 Show fit | 1.19 |
ENSDART00000110202
|
chemokine (C-C motif) ligand 27b |
|
| chr8_-_29719393 Show fit | 1.16 |
ENSDART00000077635
|
si:ch211-103n10.5 |
|
| chr12_+_46512881 Show fit | 1.12 |
ENSDART00000105454
|
|
Network of associatons between targets according to the STRING database.
First level regulatory network of cdc5l
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.3 | GO:0051014 | actin filament severing(GO:0051014) |
| 0.7 | 2.1 | GO:0030043 | actin filament fragmentation(GO:0030043) |
| 0.0 | 1.6 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
| 0.0 | 1.3 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.1 | 1.2 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.4 | 1.1 | GO:0060120 | auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120) |
| 0.1 | 1.1 | GO:0019730 | antimicrobial humoral response(GO:0019730) |
| 0.1 | 1.0 | GO:0045110 | intermediate filament bundle assembly(GO:0045110) |
| 0.0 | 1.0 | GO:0030183 | B cell differentiation(GO:0030183) |
| 0.2 | 0.9 | GO:0046952 | ketone body catabolic process(GO:0046952) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.4 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 1.6 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 1.6 | GO:0044815 | nucleosome(GO:0000786) DNA packaging complex(GO:0044815) |
| 0.0 | 1.5 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.3 | 1.3 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 0.0 | 1.3 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.9 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.2 | 0.8 | GO:0033186 | CAF-1 complex(GO:0033186) |
| 0.0 | 0.8 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 0.7 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 2.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 2.0 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.0 | 1.9 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.1 | 1.2 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.4 | 1.1 | GO:0042806 | fucose binding(GO:0042806) |
| 0.2 | 0.9 | GO:0008260 | 3-oxoacid CoA-transferase activity(GO:0008260) |
| 0.0 | 0.9 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.9 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.2 | 0.8 | GO:0070513 | death domain binding(GO:0070513) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.1 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 0.9 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.8 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 0.8 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 0.7 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 0.7 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.0 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 1.8 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.5 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.0 | 1.5 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 1.0 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 0.9 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.0 | 0.9 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 0.9 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 0.8 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.1 | 0.7 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |