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PRJNA207719: Tissue specific transcriptome profiling

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Results for bhlhe41_tfeb_usf2_tfec_max_mnta+mntb_mitfa+mitfb_mlxipl_usf1_usf1l_mxi1_srebf1

Z-value: 1.37

Transcription factors associated with bhlhe41_tfeb_usf2_tfec_max_mnta+mntb_mitfa+mitfb_mlxipl_usf1_usf1l_mxi1_srebf1

Gene Symbol Gene ID Gene Info
ENSDARG00000041691 basic helix-loop-helix family, member e41
ENSDARG00000112123 basic helix-loop-helix family, member e41
ENSDARG00000114358 basic helix-loop-helix family, member e41
ENSDARG00000010794 transcription factor EB
ENSDARG00000020228 upstream transcription factor 2, c-fos interacting
ENSDARG00000098745 transcription factor EC
ENSDARG00000024844 myc associated factor X
ENSDARG00000073988 MAX network transcriptional repressor b
ENSDARG00000101859 MAX network transcriptional repressor a
ENSDARG00000003732 melanocyte inducing transcription factor a
ENSDARG00000037833 melanocyte inducing transcription factor b
ENSDARG00000089107 MLX interacting protein like
ENSDARG00000041689 upstream transcription factor 1
ENSDARG00000014463 upstream transcription factor 1, like
ENSDARG00000109684 upstream transcription factor 1, like
ENSDARG00000114279 upstream transcription factor 1, like
ENSDARG00000040884 max interactor 1, dimerization protein
ENSDARG00000111950 max interactor 1, dimerization protein
ENSDARG00000067607 sterol regulatory element binding transcription factor 1

Activity profile of bhlhe41_tfeb_usf2_tfec_max_mnta+mntb_mitfa+mitfb_mlxipl_usf1_usf1l_mxi1_srebf1 motif

Sorted Z-values of bhlhe41_tfeb_usf2_tfec_max_mnta+mntb_mitfa+mitfb_mlxipl_usf1_usf1l_mxi1_srebf1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_20336070 1.06 ENSDART00000066385
zgc:163057
chr18_-_5509616 0.95 ENSDART00000142945
biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
chr20_-_39735952 0.90 ENSDART00000101049
ENSDART00000137485
ENSDART00000062402
tumor protein D52-like 1
chr6_+_12968101 0.81 ENSDART00000013781
minichromosome maintenance complex component 6
chr16_+_20895904 0.75 ENSDART00000052662
homeobox A13b
chr20_-_37813863 0.72 ENSDART00000147529
basic leucine zipper transcription factor, ATF-like 3
chr23_-_31913231 0.71 ENSDART00000146852
ENSDART00000085054
mitochondrial fission regulator 2
chr7_-_8374950 0.66 ENSDART00000057101
aerolysin-like protein
chr7_-_67214972 0.66 ENSDART00000156861
switching B cell complex subunit SWAP70a
chr5_-_4532516 0.64 ENSDART00000192398
cystatin 14b, tandem duplicate 1
chr18_+_44703343 0.62 ENSDART00000131510
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2, like
chr9_-_12652984 0.62 ENSDART00000052256
small ubiquitin-like modifier 3b
chr5_+_27404946 0.59 ENSDART00000121886
ENSDART00000005025
hematopoietic death receptor
chr8_+_2487883 0.59 ENSDART00000101841
dynein, light chain, LC8-type 1
chr3_+_5083407 0.59 ENSDART00000146883
si:ch73-338o16.4
chr18_-_3527988 0.57 ENSDART00000157669
calpain 5a
chr9_-_5263947 0.56 ENSDART00000088342
cytohesin 1 interacting protein
chr18_-_3527686 0.55 ENSDART00000169049
calpain 5a
chr23_+_31913292 0.55 ENSDART00000136910
armadillo repeat containing 1, like
chr19_+_791538 0.55 ENSDART00000146554
ENSDART00000138406
transmembrane protein 79a
chr17_-_32426392 0.55 ENSDART00000148455
ENSDART00000149885
ENSDART00000179314
grainyhead-like transcription factor 1
chr17_-_114121 0.52 ENSDART00000172408
ENSDART00000157784
Rho GTPase activating protein 11A
chr9_+_54178475 0.50 ENSDART00000104475
thymosin, beta 4 x
chr23_+_32028574 0.50 ENSDART00000145501
ENSDART00000143121
ENSDART00000111877
TPX2, microtubule-associated, homolog (Xenopus laevis)
chr19_-_7070691 0.49 ENSDART00000168755
TAP binding protein (tapasin), tandem duplicate 2
chr2_-_10386738 0.48 ENSDART00000016369
wntless Wnt ligand secretion mediator
chr16_+_29514473 0.48 ENSDART00000034102
cathepsin S, ortholog 2, tandem duplicate 2
chr10_-_15053507 0.48 ENSDART00000157446
ENSDART00000170441
si:ch211-95j8.5
chr8_-_31716302 0.48 ENSDART00000061832
si:dkey-46a10.3
chr23_+_36095260 0.48 ENSDART00000127384
homeobox C9a
chr20_+_38257766 0.48 ENSDART00000147485
ENSDART00000149160
chemokine (C-C motif) ligand 38, duplicate 6
chr2_+_16160906 0.47 ENSDART00000135783
selenoprotein J
chr6_+_112579 0.47 ENSDART00000034505
adaptor-related protein complex 1, mu 2 subunit
chr13_+_25200105 0.46 ENSDART00000039640
adaptor-related protein complex 3, mu 1 subunit
chr8_-_39847791 0.45 ENSDART00000139224
ENSDART00000074163
zgc:174931
chr8_+_41229233 0.45 ENSDART00000131135
zgc:152830
chr7_-_19923249 0.44 ENSDART00000078694
zgc:110591
chr11_-_438492 0.44 ENSDART00000137121
ENSDART00000133784
NUF2, NDC80 kinetochore complex component, homolog
chr16_-_26676685 0.43 ENSDART00000103431
epithelial splicing regulatory protein 1
chr25_+_245438 0.43 ENSDART00000004689
zgc:92481
chr1_-_59216197 0.42 ENSDART00000062426
lysophosphatidic acid receptor 2b
chr21_-_3700334 0.42 ENSDART00000137844
ATPase phospholipid transporting 8B1
chr13_+_22717366 0.41 ENSDART00000134122
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr1_-_52447364 0.41 ENSDART00000140740
si:ch211-217k17.10
chr15_-_17099560 0.40 ENSDART00000101724
v-mos Moloney murine sarcoma viral oncogene homolog
chr10_+_16036573 0.40 ENSDART00000188757
lamin B1
chr10_-_9089545 0.40 ENSDART00000080781
ADP-ribosylation factor-like 15b
chr23_+_26079467 0.39 ENSDART00000129617
ATPase H+ transporting accessory protein 1b
chr5_+_26204561 0.39 ENSDART00000137178
MARVEL domain containing 2b
chr9_+_23770666 0.38 ENSDART00000182493
si:ch211-219a4.3
chr18_-_15932704 0.38 ENSDART00000127769
pleckstrin homology domain containing, family G (with RhoGef domain) member 7
chr23_-_5719453 0.37 ENSDART00000033093
ladinin
chr11_-_438294 0.37 ENSDART00000040812
NUF2, NDC80 kinetochore complex component, homolog
chr18_-_1414760 0.37 ENSDART00000171881
peptidase D
chr5_-_66798729 0.37 ENSDART00000113077
im:7154036
chr4_-_13921185 0.37 ENSDART00000143202
ENSDART00000080334
YY1 associated factor 2
chr7_-_55633475 0.37 ENSDART00000149478
galactosamine (N-acetyl)-6-sulfatase
chr13_+_30696286 0.37 ENSDART00000192411
chemokine (C-X-C motif) ligand 18a, duplicate 1
chr16_+_41015163 0.37 ENSDART00000058586
DEK proto-oncogene
chr10_-_2971407 0.36 ENSDART00000132526
MARVEL domain containing 2a
chr23_+_10146542 0.36 ENSDART00000048073
zgc:171775
chr23_+_17102960 0.36 ENSDART00000053414
COMM domain containing 7
chr24_+_7631797 0.36 ENSDART00000187464
caveolae associated protein 1b
chr22_+_5120033 0.35 ENSDART00000169200
muscle-specific beta 1 integrin binding protein
chr14_-_15171435 0.35 ENSDART00000159148
ENSDART00000166622
si:dkey-77g12.1
chr22_-_17677947 0.35 ENSDART00000139911
tight junction protein 3
chr20_+_7584211 0.35 ENSDART00000132481
ENSDART00000127975
ENSDART00000144551
biogenesis of lysosomal organelles complex-1, subunit 2
chr25_-_19608382 0.35 ENSDART00000022279
ENSDART00000135201
ENSDART00000147223
ENSDART00000190220
ENSDART00000184242
ENSDART00000166824
G-2 and S-phase expressed 1
chr8_+_17167876 0.35 ENSDART00000134665
centromere protein H
chr22_+_7439186 0.35 ENSDART00000190667
zgc:92041
chr14_+_52571134 0.34 ENSDART00000166708
ribosomal protein L26
chr10_+_36662640 0.34 ENSDART00000063359
uncoupling protein 2
chr11_-_44945636 0.34 ENSDART00000157658
origin recognition complex, subunit 2
chr2_-_40191603 0.34 ENSDART00000180691
si:ch211-122l24.6
chr10_+_41159241 0.34 ENSDART00000141657
annexin A4
chr23_+_44644911 0.34 ENSDART00000140799
zgc:85858
chr19_-_27334394 0.33 ENSDART00000052359
general transcription factor IIH, polypeptide 4
chr6_+_149405 0.33 ENSDART00000161154
ferredoxin 1-like
chr8_+_17168114 0.33 ENSDART00000183901
centromere protein H
chr13_+_7164345 0.33 ENSDART00000022051
GINS complex subunit 1 (Psf1 homolog)
chr21_-_39024754 0.33 ENSDART00000056878
tnf receptor-associated factor 4b
chr6_-_10912424 0.32 ENSDART00000036456
cytochrome c, somatic b
chr1_+_26605065 0.32 ENSDART00000011645
coronin, actin binding protein, 2A
chr7_-_59054322 0.32 ENSDART00000165390
charged multivesicular body protein 5b
chr11_-_30636163 0.32 ENSDART00000140516
zgc:153665
chr14_+_23709543 0.32 ENSDART00000136909
glucosamine-6-phosphate deaminase 1
chr20_+_46213553 0.32 ENSDART00000100532
syntaxin 7-like
chr6_-_11073880 0.32 ENSDART00000035905
small ubiquitin-like modifier 3a
chr18_-_5527050 0.31 ENSDART00000145400
ENSDART00000132498
ENSDART00000146209
zgc:153317
chr16_-_5143124 0.31 ENSDART00000131876
ENSDART00000060630
ttk protein kinase
chr1_-_43727012 0.31 ENSDART00000181064
3-hydroxybutyrate dehydrogenase, type 2
chr23_+_28374458 0.31 ENSDART00000140058
ENSDART00000144240
zgc:153867
chr5_-_54714789 0.31 ENSDART00000063357
cyclin B1
chr20_-_25626198 0.30 ENSDART00000126716
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr25_+_16601839 0.30 ENSDART00000008986
ATPase H+ transporting V1 subunit E1a
chr20_-_25626428 0.30 ENSDART00000136475
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr8_-_21372446 0.30 ENSDART00000061481
ENSDART00000079293
elastase 2 like
chr5_+_31811662 0.29 ENSDART00000023463
UDP-N-acetylglucosamine pyrophosphorylase 1, like 1
chr20_+_32406011 0.29 ENSDART00000018640
ENSDART00000137910
sorting nexin 3
chr7_+_49654588 0.29 ENSDART00000025451
ENSDART00000141934
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7b
chr18_+_14693682 0.29 ENSDART00000132249
URI1, prefoldin-like chaperone
chr19_+_48176745 0.29 ENSDART00000164963
PR domain containing 1b, with ZNF domain
chr12_+_13282797 0.29 ENSDART00000137757
ENSDART00000152397
interferon regulatory factor 9
chr3_-_4552590 0.29 ENSDART00000043148
ENSDART00000132224
finTRIM family, member 43
chr2_+_30787128 0.29 ENSDART00000189233
ATPase H+ transporting V1 subunit H
chr12_-_4243268 0.28 ENSDART00000131275
zgc:92313
chr14_-_36437249 0.28 ENSDART00000016728
aspartylglucosaminidase
chr11_+_25328199 0.28 ENSDART00000141478
ENSDART00000112209
family with sequence similarity 83, member D
chr23_+_45025909 0.28 ENSDART00000188105
high mobility group box 2b
chr8_+_7316568 0.28 ENSDART00000140874
selenoprotein H
chr1_+_54043563 0.28 ENSDART00000149760
TRIO and F-actin binding protein a
chr13_+_29292011 0.28 ENSDART00000115023
poly (ADP-ribose) glycohydrolase a
chr20_+_15565926 0.28 ENSDART00000063917
si:dkey-86e18.1
chr5_-_54714525 0.28 ENSDART00000150138
ENSDART00000150070
cyclin B1
chr19_-_32500373 0.27 ENSDART00000052104
alpha-L-fucosidase 1, tandem duplicate 1
chr24_-_16917086 0.27 ENSDART00000110715
carboxymethylenebutenolidase homolog (Pseudomonas)
chr17_-_51224800 0.27 ENSDART00000150089
presenilin 1
chr2_-_10877765 0.27 ENSDART00000100607
cell division cycle 7 homolog (S. cerevisiae)
chr13_-_37647209 0.27 ENSDART00000189102
si:dkey-188i13.10
chr13_-_45201300 0.27 ENSDART00000074750
ENSDART00000180265
runt-related transcription factor 3
chr21_-_15674802 0.27 ENSDART00000136666
matrix metallopeptidase 11b
chr22_-_27115241 0.27 ENSDART00000019442
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
chr9_-_2572790 0.27 ENSDART00000135076
ENSDART00000016710
secernin 3
chr16_-_45178430 0.26 ENSDART00000165186
si:dkey-33i11.9
chr2_+_30786773 0.26 ENSDART00000019029
ENSDART00000145681
ATPase H+ transporting V1 subunit H
chr7_-_32629458 0.26 ENSDART00000001376
ADP-ribosylation factor-like 14 effector protein
chr22_-_10165446 0.26 ENSDART00000142012
RanBP-type and C3HC4-type zinc finger containing 1
chr11_+_42556395 0.26 ENSDART00000039206
ribosomal protein S23
chr9_+_563547 0.26 ENSDART00000162761

chr17_+_32622933 0.25 ENSDART00000077418
cathepsin Ba
chr25_+_10547228 0.25 ENSDART00000067678
zgc:110339
chr18_+_26422124 0.25 ENSDART00000060245
cathepsin H
chr14_+_23709134 0.25 ENSDART00000191162
ENSDART00000179754
ENSDART00000054266
glucosamine-6-phosphate deaminase 1
chr14_+_21685537 0.25 ENSDART00000128717
ENSDART00000144503
RAN, member RAS oncogene family
chr17_+_44441042 0.25 ENSDART00000142123
adaptor-related protein complex 5, mu 1 subunit
chr17_-_37395460 0.25 ENSDART00000148160
ENSDART00000075975
cysteine-rich protein 1
chr3_+_36617024 0.25 ENSDART00000189957
pyridoxal-dependent decarboxylase domain containing 1
chr4_-_7673165 0.25 ENSDART00000028171
leukotriene A4 hydrolase
chr21_+_7298687 0.25 ENSDART00000187746

chr4_-_992063 0.24 ENSDART00000181630
ENSDART00000183898
ENSDART00000160902
N-acetylgalactosaminidase, alpha
chr7_+_19817306 0.24 ENSDART00000044425

chr5_+_20366453 0.24 ENSDART00000193141
coronin, actin binding protein, 1Ca
chr5_+_57320113 0.24 ENSDART00000036331
ATPase H+ transporting V1 subunit G1
chr14_-_35414559 0.24 ENSDART00000145033
ribonuclease H2, subunit C
chr1_+_10318089 0.24 ENSDART00000029774
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1b
chr8_-_25817106 0.24 ENSDART00000099364
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr20_-_25631256 0.24 ENSDART00000048164
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr16_+_23961276 0.24 ENSDART00000192754
apolipoprotein Eb
chr3_-_6441619 0.24 ENSDART00000157771
ENSDART00000166758
small ubiquitin-like modifier 2b
chr7_+_26466826 0.24 ENSDART00000058908
mannose-P-dolichol utilization defect 1b
chr24_-_27419198 0.23 ENSDART00000141124
chemokine (C-C motif) ligand 34b, duplicate 4
chr5_-_12560569 0.23 ENSDART00000133587
WD repeat and SOCS box containing 2
chr15_+_1534644 0.23 ENSDART00000130413
structural maintenance of chromosomes 4
chr16_+_23960933 0.23 ENSDART00000146077
apolipoprotein Eb
chr25_-_6447835 0.23 ENSDART00000012820
snurportin 1
chr10_-_15644904 0.23 ENSDART00000138389
ENSDART00000101191
ENSDART00000186559
ENSDART00000122170
structural maintenance of chromosomes 5
chr4_-_5831522 0.23 ENSDART00000008898
forkhead box M1
chr20_-_20821783 0.23 ENSDART00000152577
ENSDART00000027603
ENSDART00000145601
creatine kinase, brain b
chr16_+_33143503 0.23 ENSDART00000058471
ENSDART00000179385
rhomboid, veinlet-like 2 (Drosophila)
chr1_-_43727418 0.22 ENSDART00000133715
ENSDART00000074597
ENSDART00000132542
ENSDART00000181792
3-hydroxybutyrate dehydrogenase, type 2
si:dkey-162b23.4
chr23_+_36063599 0.22 ENSDART00000103147
homeobox C12a
chr23_-_29556844 0.22 ENSDART00000138021
retinol binding protein 7a, cellular
chr7_+_57109214 0.22 ENSDART00000135068
ENSDART00000098412
enolase superfamily member 1
chr12_-_9516981 0.22 ENSDART00000106285
si:ch211-207i20.3
chr25_+_34014523 0.22 ENSDART00000182856
annexin A2a
chr19_+_19772765 0.22 ENSDART00000182028
ENSDART00000161019
homeobox A3a
chr16_+_12022543 0.22 ENSDART00000012673
guanine nucleotide binding protein (G protein), beta polypeptide 3a
chr5_-_67365006 0.22 ENSDART00000136116
uracil DNA glycosylase a
chr14_+_94946 0.22 ENSDART00000165766
ENSDART00000163778
minichromosome maintenance complex component 7
chr6_-_55423220 0.22 ENSDART00000158929
cathepsin A
chr10_-_29768556 0.22 ENSDART00000052787
vacuolar protein sorting 11
chr10_+_16036246 0.21 ENSDART00000141586
ENSDART00000135868
ENSDART00000065037
ENSDART00000124502
lamin B1
chr3_-_18805225 0.21 ENSDART00000133471
ENSDART00000131758
methionine sulfoxide reductase B1a
chr24_-_7995748 0.21 ENSDART00000158566
biogenesis of lysosomal organelles complex-1, subunit 5, muted
chr10_+_20070178 0.21 ENSDART00000027612
ENSDART00000145264
ENSDART00000172713
exportin 7
chr23_-_19486571 0.21 ENSDART00000009092
family with sequence similarity 208, member Ab
chr25_-_6223567 0.21 ENSDART00000067512
proteasome subunit alpha 4
chr1_-_59252973 0.21 ENSDART00000167061
si:ch1073-286c18.5
chr7_+_22293894 0.21 ENSDART00000056790
transmembrane protein 256
chr13_+_25199849 0.21 ENSDART00000139209
ENSDART00000130876
adaptor-related protein complex 3, mu 1 subunit
chr1_+_34496855 0.21 ENSDART00000012873
Kruppel-like factor 12a
chr11_+_6281647 0.21 ENSDART00000002459
cystinosin, lysosomal cystine transporter
chr6_-_37422841 0.21 ENSDART00000138351
cystathionase (cystathionine gamma-lyase)
chr15_-_28596507 0.21 ENSDART00000156800
si:ch211-225b7.5
chr18_-_26894732 0.21 ENSDART00000147735
ENSDART00000188938

si:dkey-24l11.2
chr7_-_33351485 0.20 ENSDART00000146420
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr8_+_13106760 0.20 ENSDART00000029308
integrin, beta 4
chr20_+_2589414 0.20 ENSDART00000043626
interleukin 20 receptor, alpha
chr15_+_19838458 0.20 ENSDART00000101204
activated leukocyte cell adhesion molecule b
chr8_+_13389115 0.20 ENSDART00000184428
ENSDART00000154266
ENSDART00000049469
Janus kinase 3 (a protein tyrosine kinase, leukocyte)
chr15_-_43327911 0.20 ENSDART00000077386
protease, serine, 16 (thymus)
chr14_+_16287968 0.20 ENSDART00000106593
pre-mRNA processing factor 19
chr3_+_34120191 0.20 ENSDART00000020017
ENSDART00000151700
aldehyde dehydrogenase 3 family, member B1
chr9_-_27868267 0.20 ENSDART00000079502
debranching RNA lariats 1
chr4_-_17669881 0.20 ENSDART00000066997
DNA-damage regulated autophagy modulator 1
chr3_-_15734358 0.19 ENSDART00000137325
major vault protein
chr15_-_43625549 0.19 ENSDART00000168589
cathepsin C
chr9_-_11587070 0.19 ENSDART00000030995
uridine monophosphate synthetase
chr5_+_50913357 0.19 ENSDART00000092938
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein a
chr9_+_54686686 0.19 ENSDART00000066198
RAB9A, member RAS oncogene family

Network of associatons between targets according to the STRING database.

First level regulatory network of bhlhe41_tfeb_usf2_tfec_max_mnta+mntb_mitfa+mitfb_mlxipl_usf1_usf1l_mxi1_srebf1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:1902102 meiotic cell cycle phase transition(GO:0044771) metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133)
0.2 0.7 GO:0071830 chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831)
0.2 0.6 GO:0006041 glucosamine metabolic process(GO:0006041) glucosamine catabolic process(GO:0006043)
0.2 0.7 GO:0061015 RNA import into nucleus(GO:0006404) snRNA import into nucleus(GO:0061015)
0.2 0.5 GO:0061355 Wnt protein secretion(GO:0061355)
0.1 0.6 GO:0036462 TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.1 1.4 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 0.5 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.1 1.2 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 0.3 GO:0019418 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.1 0.3 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.1 0.6 GO:0048069 eye pigmentation(GO:0048069)
0.1 0.5 GO:1901207 regulation of heart looping(GO:1901207)
0.1 0.5 GO:0003334 keratinocyte development(GO:0003334)
0.1 0.8 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.1 0.5 GO:0019184 nonribosomal peptide biosynthetic process(GO:0019184)
0.1 0.2 GO:0071236 cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.1 0.5 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 0.6 GO:0016137 glycoside metabolic process(GO:0016137) glycoside catabolic process(GO:0016139)
0.1 0.3 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 0.2 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.3 GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563)
0.1 0.5 GO:0060017 parathyroid gland development(GO:0060017)
0.1 0.5 GO:0060036 notochord cell vacuolation(GO:0060036)
0.1 0.2 GO:0000393 spliceosomal conformational changes to generate catalytic conformation(GO:0000393)
0.1 0.6 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.1 0.3 GO:0097510 base-excision repair, AP site formation via deaminated base removal(GO:0097510)
0.1 0.2 GO:0090148 membrane fission(GO:0090148)
0.1 0.2 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.1 0.5 GO:0042989 sequestering of actin monomers(GO:0042989)
0.1 0.2 GO:0006097 glyoxylate cycle(GO:0006097)
0.1 1.0 GO:0015671 oxygen transport(GO:0015671)
0.1 0.3 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.1 0.2 GO:0006168 adenine salvage(GO:0006168) adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.0 0.2 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.0 0.2 GO:0006691 leukotriene metabolic process(GO:0006691) leukotriene biosynthetic process(GO:0019370)
0.0 0.3 GO:0051310 metaphase plate congression(GO:0051310)
0.0 0.2 GO:1903232 melanosome assembly(GO:1903232)
0.0 0.9 GO:2001235 positive regulation of apoptotic signaling pathway(GO:2001235)
0.0 0.4 GO:1902038 positive regulation of hematopoietic stem cell differentiation(GO:1902038)
0.0 0.1 GO:0006864 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.0 0.3 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.1 GO:0019852 L-ascorbic acid metabolic process(GO:0019852) water-soluble vitamin biosynthetic process(GO:0042364)
0.0 0.2 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.1 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.5 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.0 0.6 GO:0051383 kinetochore organization(GO:0051383)
0.0 0.2 GO:0030101 natural killer cell activation(GO:0030101)
0.0 0.5 GO:0033260 nuclear DNA replication(GO:0033260)
0.0 0.3 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.3 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.0 0.1 GO:0006004 fucose metabolic process(GO:0006004)
0.0 0.4 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.1 GO:0009838 abscission(GO:0009838) mitotic cytokinesis checkpoint(GO:0044878)
0.0 0.4 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0 0.5 GO:0030311 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.2 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260) protein localization to early endosome(GO:1902946)
0.0 0.1 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.1 GO:1903504 regulation of spindle checkpoint(GO:0090231) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.2 GO:1902369 negative regulation of RNA catabolic process(GO:1902369)
0.0 0.3 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 0.1 GO:0006272 leading strand elongation(GO:0006272)
0.0 0.4 GO:0030104 water homeostasis(GO:0030104)
0.0 0.1 GO:0002532 production of molecular mediator involved in inflammatory response(GO:0002532)
0.0 0.2 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.0 0.2 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.0 GO:0071514 genetic imprinting(GO:0071514)
0.0 0.9 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.1 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.0 0.1 GO:0015670 carbon dioxide transport(GO:0015670)
0.0 0.1 GO:0098535 de novo centriole assembly(GO:0098535)
0.0 0.3 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.2 GO:0006177 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.0 0.2 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.0 0.4 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.2 GO:0021885 forebrain cell migration(GO:0021885)
0.0 0.1 GO:0048389 intermediate mesoderm development(GO:0048389)
0.0 0.4 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.0 0.1 GO:1904398 positive regulation of neuromuscular junction development(GO:1904398)
0.0 0.1 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
0.0 0.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 1.1 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.1 GO:1903426 regulation of reactive oxygen species biosynthetic process(GO:1903426)
0.0 0.3 GO:0006517 protein deglycosylation(GO:0006517)
0.0 0.1 GO:0071169 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.0 0.2 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.1 GO:0060334 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 0.1 GO:0002432 granuloma formation(GO:0002432) chronic inflammatory response(GO:0002544) regulation of granuloma formation(GO:0002631) regulation of chronic inflammatory response(GO:0002676)
0.0 0.1 GO:0055091 phospholipid homeostasis(GO:0055091)
0.0 0.4 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.1 GO:0051037 histone displacement(GO:0001207) regulation of transcription involved in meiotic cell cycle(GO:0051037) positive regulation of transcription involved in meiotic cell cycle(GO:0051039)
0.0 0.1 GO:0016446 somatic diversification of immune receptors via somatic mutation(GO:0002566) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.0 0.2 GO:0019346 homoserine metabolic process(GO:0009092) cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344) transsulfuration(GO:0019346)
0.0 0.1 GO:0042256 mature ribosome assembly(GO:0042256) assembly of large subunit precursor of preribosome(GO:1902626)
0.0 0.1 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.0 0.4 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)
0.0 0.2 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.2 GO:0070293 renal absorption(GO:0070293)
0.0 0.2 GO:2001271 negative regulation of execution phase of apoptosis(GO:1900118) regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.1 GO:2000009 regulation of protein localization to cell surface(GO:2000008) negative regulation of protein localization to cell surface(GO:2000009)
0.0 0.1 GO:0034244 negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 0.3 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.2 GO:1990845 adaptive thermogenesis(GO:1990845)
0.0 0.1 GO:0002369 T cell cytokine production(GO:0002369)
0.0 0.3 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.2 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 0.8 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.1 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.1 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.0 0.1 GO:0005997 xylulose metabolic process(GO:0005997)
0.0 0.1 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 0.1 GO:1903358 regulation of Golgi organization(GO:1903358)
0.0 0.1 GO:0070126 mitochondrial translational termination(GO:0070126)
0.0 0.1 GO:0006585 dopamine biosynthetic process from tyrosine(GO:0006585) dopamine biosynthetic process(GO:0042416)
0.0 0.2 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.3 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.1 GO:0021559 auditory receptor cell fate commitment(GO:0009912) trigeminal nerve development(GO:0021559) inner ear receptor cell fate commitment(GO:0060120)
0.0 0.4 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.0 0.1 GO:0038093 Fc receptor signaling pathway(GO:0038093)
0.0 0.1 GO:1901255 nucleotide-excision repair involved in interstrand cross-link repair(GO:1901255)
0.0 0.1 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.1 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.0 0.1 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.0 0.1 GO:1904031 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0 0.1 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.0 0.1 GO:0050907 detection of chemical stimulus involved in sensory perception(GO:0050907)
0.0 0.1 GO:0048478 replication fork protection(GO:0048478)
0.0 0.2 GO:0071156 regulation of cell cycle arrest(GO:0071156)
0.0 0.1 GO:0061010 gall bladder development(GO:0061010)
0.0 0.1 GO:1902024 L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.0 0.1 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.0 0.0 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.2 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247)
0.0 0.1 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 0.1 GO:0045938 positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.0 0.0 GO:0098773 skin epidermis development(GO:0098773)
0.0 0.1 GO:0043011 myeloid dendritic cell activation(GO:0001773) myeloid dendritic cell differentiation(GO:0043011)
0.0 0.5 GO:0030574 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 0.1 GO:0090155 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.0 0.0 GO:0045002 double-strand break repair via single-strand annealing(GO:0045002)
0.0 0.0 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.0 0.4 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.0 GO:0050787 response to mercury ion(GO:0046689) detoxification of mercury ion(GO:0050787)
0.0 0.5 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.0 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525) negative regulation of transposition, RNA-mediated(GO:0010526) transposition, RNA-mediated(GO:0032197) positive regulation of neuron apoptotic process(GO:0043525) positive regulation of neuron death(GO:1901216)
0.0 0.4 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.1 GO:2000171 negative regulation of dendrite development(GO:2000171)
0.0 0.0 GO:1903644 regulation of protein folding(GO:1903332) positive regulation of protein folding(GO:1903334) regulation of chaperone-mediated protein folding(GO:1903644) positive regulation of chaperone-mediated protein folding(GO:1903646)
0.0 0.1 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.0 0.1 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.0 0.0 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.0 0.2 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435) negative regulation of proteasomal protein catabolic process(GO:1901799) negative regulation of proteolysis involved in cellular protein catabolic process(GO:1903051)
0.0 0.2 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.4 GO:0009225 nucleotide-sugar metabolic process(GO:0009225)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.1 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.1 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.1 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.0 0.1 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.4 GO:0016180 snRNA processing(GO:0016180)
0.0 0.5 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 0.0 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.1 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0 0.1 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.2 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.0 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.4 GO:0050821 protein stabilization(GO:0050821)
0.0 0.1 GO:0006012 galactose metabolic process(GO:0006012)
0.0 0.1 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
0.0 0.0 GO:0009447 polyamine catabolic process(GO:0006598) putrescine catabolic process(GO:0009447)
0.0 0.1 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.0 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.0 0.1 GO:0017145 stem cell division(GO:0017145)
0.0 0.2 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.0 0.6 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.0 0.1 GO:0072028 nephron morphogenesis(GO:0072028)
0.0 0.1 GO:1904356 regulation of telomere maintenance via telomere lengthening(GO:1904356)
0.0 0.1 GO:2000758 positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.0 GO:0060631 regulation of meiosis I(GO:0060631)
0.0 0.0 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.0 0.2 GO:0031581 hemidesmosome assembly(GO:0031581)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.2 0.7 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 0.8 GO:0031262 Ndc80 complex(GO:0031262)
0.1 0.5 GO:0061689 tricellular tight junction(GO:0061689)
0.1 0.5 GO:0005880 nuclear microtubule(GO:0005880)
0.1 1.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.5 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.1 0.5 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 1.2 GO:0042555 MCM complex(GO:0042555)
0.1 0.2 GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane(GO:0098556)
0.1 0.3 GO:0000811 GINS complex(GO:0000811)
0.1 0.4 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.1 0.8 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 0.2 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 0.3 GO:0043198 dendritic shaft(GO:0043198)
0.1 0.6 GO:0030904 retromer complex(GO:0030904)
0.1 0.2 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
0.0 0.3 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.2 GO:0031085 BLOC-3 complex(GO:0031085)
0.0 1.6 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 0.3 GO:0030897 HOPS complex(GO:0030897)
0.0 0.6 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.9 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.1 GO:0032044 DSIF complex(GO:0032044)
0.0 0.2 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.0 0.2 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.2 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.0 0.3 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.5 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.0 0.2 GO:0035101 FACT complex(GO:0035101)
0.0 0.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.7 GO:0046930 pore complex(GO:0046930)
0.0 0.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.1 GO:0061673 mitotic spindle astral microtubule(GO:0061673)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.1 GO:0032301 MutSalpha complex(GO:0032301)
0.0 0.2 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.3 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.1 GO:0000818 nuclear MIS12/MIND complex(GO:0000818)
0.0 0.0 GO:0031082 BLOC complex(GO:0031082)
0.0 0.2 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.1 GO:0090443 FAR/SIN/STRIPAK complex(GO:0090443)
0.0 0.8 GO:0016605 PML body(GO:0016605)
0.0 0.1 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.0 0.1 GO:0070390 transcription export complex 2(GO:0070390)
0.0 0.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.1 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.0 0.4 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.1 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.0 0.1 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.1 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.1 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.1 GO:0097255 R2TP complex(GO:0097255)
0.0 0.1 GO:0032797 SMN complex(GO:0032797)
0.0 0.2 GO:0014704 intercalated disc(GO:0014704)
0.0 0.1 GO:0070209 ASTRA complex(GO:0070209)
0.0 0.1 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.1 GO:1902737 dendritic spine neck(GO:0044326) dendritic filopodium(GO:1902737)
0.0 0.1 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.1 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 0.9 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 0.0 GO:0072380 TRC complex(GO:0072380)
0.0 0.2 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.1 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.0 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.1 GO:0031526 brush border membrane(GO:0031526)
0.0 0.6 GO:0030496 midbody(GO:0030496)
0.0 0.1 GO:0071540 eukaryotic translation initiation factor 3 complex, eIF3e(GO:0071540)
0.0 0.1 GO:0070652 HAUS complex(GO:0070652)
0.0 0.0 GO:1990879 CST complex(GO:1990879)
0.0 0.1 GO:0055087 Ski complex(GO:0055087)
0.0 0.2 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.1 GO:0032021 NELF complex(GO:0032021)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.1 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.1 GO:0033557 Slx1-Slx4 complex(GO:0033557)
0.0 0.1 GO:1990923 PET complex(GO:1990923)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639)
0.2 1.2 GO:1990518 ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518)
0.2 0.7 GO:0048030 disaccharide binding(GO:0048030)
0.2 0.7 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.2 0.6 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.1 0.3 GO:0004560 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
0.1 0.4 GO:0008117 sphinganine-1-phosphate aldolase activity(GO:0008117)
0.1 1.1 GO:0031720 haptoglobin binding(GO:0031720)
0.1 0.3 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
0.1 0.3 GO:0070224 sulfide:quinone oxidoreductase activity(GO:0070224)
0.1 0.4 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 0.4 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.1 0.4 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.1 0.3 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.1 0.3 GO:0004649 poly(ADP-ribose) glycohydrolase activity(GO:0004649)
0.1 0.3 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 0.2 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.1 0.4 GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity(GO:0003977)
0.1 0.2 GO:0004557 alpha-galactosidase activity(GO:0004557)
0.1 0.7 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.3 GO:0033745 L-methionine-(R)-S-oxide reductase activity(GO:0033745)
0.1 1.0 GO:0031386 protein tag(GO:0031386)
0.1 0.5 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
0.1 0.2 GO:0004904 interferon receptor activity(GO:0004904)
0.1 0.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 0.2 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.0 0.1 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.0 0.3 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.1 GO:0015315 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0 0.1 GO:0047453 ATP-dependent NAD(P)H-hydrate dehydratase activity(GO:0047453) ADP-dependent NAD(P)H-hydrate dehydratase activity(GO:0052855)
0.0 0.1 GO:0042806 fucose binding(GO:0042806)
0.0 0.6 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 1.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.5 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.1 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.0 0.7 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.3 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.1 GO:0003999 adenine phosphoribosyltransferase activity(GO:0003999)
0.0 0.1 GO:0043734 DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0 0.2 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.1 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.1 GO:0008397 sterol 12-alpha-hydroxylase activity(GO:0008397)
0.0 0.3 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.0 0.2 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.0 1.0 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.5 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.0 0.1 GO:0004422 hypoxanthine phosphoribosyltransferase activity(GO:0004422)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049) nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.1 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0 0.1 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0 0.1 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.0 0.4 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.2 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.0 0.1 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.1 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 0.5 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0032138 guanine/thymine mispair binding(GO:0032137) single base insertion or deletion binding(GO:0032138) single thymine insertion binding(GO:0032143) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357) mismatch repair complex binding(GO:0032404) MutLalpha complex binding(GO:0032405)
0.0 0.1 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.3 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.1 GO:0043531 ADP binding(GO:0043531)
0.0 0.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.2 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 1.3 GO:0008009 chemokine activity(GO:0008009)
0.0 0.8 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.5 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.3 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.3 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.5 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.1 GO:0003978 UDP-glucose 4-epimerase activity(GO:0003978)
0.0 0.1 GO:0019777 Atg12 transferase activity(GO:0019777)
0.0 0.3 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.1 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.0 0.1 GO:0003913 DNA photolyase activity(GO:0003913)
0.0 0.2 GO:0055102 phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
0.0 0.1 GO:0016531 copper chaperone activity(GO:0016531)
0.0 0.5 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.1 GO:0017050 D-erythro-sphingosine kinase activity(GO:0017050)
0.0 0.4 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.1 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.0 0.3 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.1 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.1 GO:0008026 ATP-dependent DNA helicase activity(GO:0004003) ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.0 0.1 GO:0070513 death domain binding(GO:0070513)
0.0 0.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.0 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.0 0.1 GO:0016936 galactoside binding(GO:0016936)
0.0 0.1 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.0 0.1 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 0.1 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 0.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.0 GO:0047690 aspartyltransferase activity(GO:0047690)
0.0 0.2 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.4 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.1 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 0.1 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.1 GO:0005351 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 0.2 GO:0072542 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.1 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.1 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.0 0.1 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.1 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.1 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046) core promoter binding(GO:0001047)
0.0 0.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.2 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.0 GO:0016748 succinyltransferase activity(GO:0016748)
0.0 0.1 GO:0052796 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 0.1 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.5 GO:0030295 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.0 0.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.1 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 0.1 GO:0050699 WW domain binding(GO:0050699)
0.0 0.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.2 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.3 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.9 PID AURORA A PATHWAY Aurora A signaling
0.0 0.3 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.0 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.3 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.1 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.6 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.0 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.3 PID MYC PATHWAY C-MYC pathway
0.0 0.4 PID ATR PATHWAY ATR signaling pathway
0.0 0.3 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.3 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 1.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 0.1 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 1.3 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 1.0 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 0.6 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.5 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.3 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 0.4 REACTOME SIGNALING BY NOTCH4 Genes involved in Signaling by NOTCH4
0.0 1.4 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.7 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.6 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 0.1 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.7 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.5 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.4 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.1 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.2 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.3 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 1.1 REACTOME RNA POL II PRE TRANSCRIPTION EVENTS Genes involved in RNA Polymerase II Pre-transcription Events
0.0 0.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.0 REACTOME MRNA CAPPING Genes involved in mRNA Capping
0.0 0.0 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.0 0.8 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.6 REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX Genes involved in CDT1 association with the CDC6:ORC:origin complex
0.0 0.1 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 0.2 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.6 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.3 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.3 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.6 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.3 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.1 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.1 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.8 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.2 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 0.3 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 0.2 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.0 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions