ISMARA results: bhlha15_bhlhe23+si:ch211-196c10.13

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PRJNA207719: Tissue specific transcriptome profiling

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Results for bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22

Z-value: 1.37

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Transcription factors associated with bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22

Gene Symbol	Gene ID	Gene Info
bhlha15 NCBI UniProt	ENSDARG00000045166	basic helix-loop-helix family, member a15
bhlhe23 NCBI UniProt	ENSDARG00000037588	basic helix-loop-helix family, member e23
si_ch211-196c10.13 NCBI UniProt	ENSDARG00000096756	si_ch211-196c10.13
bhlhe22 NCBI UniProt	ENSDARG00000058039	basic helix-loop-helix family, member e22

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
bhlhe22	dr11_v1_chr24_+_24461341_24461341	0.98	3.0e-03	Click!
bhlhe23	dr11_v1_chr23_-_17657348_17657348	0.97	6.5e-03	Click!
si:ch211-196c10.13	dr11_v1_chr8_+_23142946_23142946	0.95	1.2e-02	Click!
bhlha15	dr11_v1_chr12_+_17754859_17754859	0.46	4.4e-01	Click!

Activity profile of bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22 motif

Sorted Z-values of bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr21_+_11468642 Show fit	2.43	ENSDART00000041869	grin1a NCBI UniProt Show fit	glutamate receptor, ionotropic, N-methyl D-aspartate 1a
chr2_-_27775236 Show fit	2.41	ENSDART00000187983	XKR4 NCBI UniProt Show fit	zgc:123035
chr2_-_27774783 Show fit	2.25	ENSDART00000161864	XKR4 NCBI UniProt Show fit	zgc:123035
chr14_-_4682114 Show fit	2.25	ENSDART00000014454	gabra4 NCBI UniProt Show fit	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4
chr4_-_8882572 Show fit	2.23	ENSDART00000190060	mpped1 NCBI UniProt Show fit	metallophosphoesterase domain containing 1
chr10_+_22012389 Show fit	2.16	ENSDART00000035188	kcnip1b NCBI UniProt Show fit	Kv channel interacting protein 1 b
chr14_-_4556896 Show fit	2.04	ENSDART00000044678 ENSDART00000192863	GABRA2 NCBI UniProt Show fit	gamma-aminobutyric acid type A receptor alpha2 subunit
chr5_-_27994679 Show fit	1.61	ENSDART00000132740	ppp3cca NCBI UniProt Show fit	protein phosphatase 3, catalytic subunit, gamma isozyme, a
chr10_-_31440500 Show fit	1.60	ENSDART00000024778	robo3 NCBI UniProt Show fit	roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr1_-_16507812 Show fit	1.55	ENSDART00000169081	mtmr7b NCBI UniProt Show fit	myotubularin related protein 7b

Showing 1 to 10 of 131 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	2.7	GO:0071361	cellular response to ethanol(GO:0071361)
0.1	2.4	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1	2.2	GO:0051932	synaptic transmission, GABAergic(GO:0051932)
0.1	1.6	GO:0016199	axon midline choice point recognition(GO:0016199)
0.4	1.5	GO:0060074	synapse maturation(GO:0060074)
0.0	1.5	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0	1.5	GO:0046856	phosphatidylinositol dephosphorylation(GO:0046856)
0.0	1.4	GO:0006979	response to oxidative stress(GO:0006979)
0.1	1.2	GO:0048936	peripheral nervous system neuron axonogenesis(GO:0048936)
0.0	1.0	GO:1902807	negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)

Showing 1 to 10 of 41 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.9	GO:0034707	chloride channel complex(GO:0034707)
0.2	2.4	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.3	1.6	GO:0005955	calcineurin complex(GO:0005955)
0.0	1.1	GO:0055037	recycling endosome(GO:0055037)
0.0	1.0	GO:0099634	postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1	0.7	GO:0032593	insulin-responsive compartment(GO:0032593)
0.1	0.6	GO:0005943	phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0	0.5	GO:0090665	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1	0.3	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.2	GO:0071564	npBAF complex(GO:0071564)

Showing 1 to 10 of 13 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.7	GO:0016934	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1	2.4	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.2	2.2	GO:0005237	inhibitory extracellular ligand-gated ion channel activity(GO:0005237) benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.3	1.6	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1	1.6	GO:0098632	protein binding involved in cell-cell adhesion(GO:0098632)
0.0	1.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	1.5	GO:0004438	phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.1	1.2	GO:0015386	monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.1	1.2	GO:0033549	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.0	1.0	GO:0019902	phosphatase binding(GO:0019902)

Showing 1 to 10 of 25 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.4	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.0	1.0	PID IGF1 PATHWAY	IGF1 pathway
0.0	0.7	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
0.0	0.3	PID SHP2 PATHWAY	SHP2 signaling
0.0	0.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network

Showing 1 to 5 of 5 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	7.0	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport
0.0	1.6	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.0	0.6	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	0.5	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	0.4	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	0.4	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.4	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	0.2	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.2	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.2	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression

Showing 1 to 10 of 12 entries

Results for bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22

Z-value: 1.37

Motif logo

Transcription factors associated with bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22

Activity-expression correlation:

Activity profile of bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22 motif

Sorted Z-values of bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: