ISMARA results: bcl6aa+bcl6ab+bcl6b

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PRJNA207719: Tissue specific transcriptome profiling

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Results for bcl6aa+bcl6ab+bcl6b

Z-value: 1.02

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Transcription factors associated with bcl6aa+bcl6ab+bcl6b

Gene Symbol	Gene ID	Gene Info
bcl6ab NCBI UniProt	ENSDARG00000069295	BCL6A transcription repressor b
bcl6b NCBI UniProt	ENSDARG00000069335	BCL6B transcription repressor
bcl6aa NCBI UniProt	ENSDARG00000070864	BCL6A transcription repressor a
bcl6aa NCBI UniProt	ENSDARG00000111395	BCL6A transcription repressor a
bcl6aa NCBI UniProt	ENSDARG00000112502	BCL6A transcription repressor a
bcl6aa NCBI UniProt	ENSDARG00000116260	BCL6A transcription repressor a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
bcl6a	dr11_v1_chr6_-_28222592_28222592	-0.79	1.1e-01	Click!
bcl6b	dr11_v1_chr7_+_20019125_20019125	-0.75	1.4e-01	Click!
bcl6ab	dr11_v1_chr2_-_10098191_10098191	-0.45	4.4e-01	Click!

Activity profile of bcl6aa+bcl6ab+bcl6b motif

Sorted Z-values of bcl6aa+bcl6ab+bcl6b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr25_-_17395315 Show fit	0.79	ENSDART00000064596	cyp2x8 NCBI UniProt Show fit	cytochrome P450, family 2, subfamily X, polypeptide 8
chr16_-_36834505 Show fit	0.76	ENSDART00000141275 ENSDART00000139588 ENSDART00000041993	pnp4b NCBI UniProt Show fit	purine nucleoside phosphorylase 4b
chr14_+_11457500 Show fit	0.74	ENSDART00000169202	si:ch211-153b23.5 NCBI UniProt Show fit	si:ch211-153b23.5
chr5_-_63509581 Show fit	0.72	ENSDART00000097325	c5 NCBI UniProt Show fit	complement component 5
chr2_-_10703621 Show fit	0.66	ENSDART00000005944	rpl5a NCBI UniProt Show fit	ribosomal protein L5a
chr16_-_45917322 Show fit	0.65	ENSDART00000060822	afp4 NCBI UniProt Show fit	antifreeze protein type IV
chr3_+_19299309 Show fit	0.62	ENSDART00000046297 ENSDART00000146955	ldlra NCBI UniProt Show fit	low density lipoprotein receptor a
chr11_-_8167799 Show fit	0.62	ENSDART00000133574 ENSDART00000024046 ENSDART00000146940	uox NCBI UniProt Show fit	urate oxidase
chr20_+_23440632 Show fit	0.59	ENSDART00000180685 ENSDART00000042820	si:dkey-90m5.4 NCBI UniProt Show fit	si:dkey-90m5.4
chr19_-_5351980 Show fit	0.57	ENSDART00000163304 ENSDART00000027701	krt92 NCBI UniProt Show fit	keratin 92

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of bcl6aa+bcl6ab+bcl6b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.7	GO:0042738	drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0	0.9	GO:0000027	ribosomal large subunit assembly(GO:0000027)
0.3	0.8	GO:0016045	detection of biotic stimulus(GO:0009595) detection of bacterium(GO:0016045) detection of other organism(GO:0098543) detection of external biotic stimulus(GO:0098581)
0.0	0.8	GO:0060030	dorsal convergence(GO:0060030)
0.1	0.7	GO:0046426	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.2	0.6	GO:0046415	urate catabolic process(GO:0019628) urate metabolic process(GO:0046415)
0.2	0.6	GO:0002532	production of molecular mediator involved in inflammatory response(GO:0002532)
0.1	0.6	GO:0032367	intracellular cholesterol transport(GO:0032367)
0.0	0.5	GO:0015693	magnesium ion transport(GO:0015693)
0.0	0.5	GO:0071219	cellular response to molecule of bacterial origin(GO:0071219) cellular response to lipopolysaccharide(GO:0071222)

Showing 1 to 10 of 76 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.5	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	0.7	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.1	0.4	GO:0071012	U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.1	0.4	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0	0.4	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.1	0.3	GO:0000811	GINS complex(GO:0000811)
0.0	0.3	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.0	0.3	GO:0048787	presynaptic active zone membrane(GO:0048787)
0.1	0.2	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0	0.2	GO:0032133	chromosome passenger complex(GO:0032133)

Showing 1 to 10 of 17 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.7	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.3	0.8	GO:0016019	peptidoglycan receptor activity(GO:0016019)
0.1	0.8	GO:0004731	purine-nucleoside phosphorylase activity(GO:0004731)
0.1	0.7	GO:0008097	5S rRNA binding(GO:0008097)
0.2	0.6	GO:0030228	lipoprotein particle receptor activity(GO:0030228)
0.1	0.6	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.0	0.5	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.0	0.5	GO:0030515	snoRNA binding(GO:0030515)
0.1	0.4	GO:0005461	UDP-glucuronic acid transmembrane transporter activity(GO:0005461) UDP-N-acetylgalactosamine transmembrane transporter activity(GO:0005463)
0.1	0.4	GO:0047105	aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)

Showing 1 to 10 of 55 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.1	0.5	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.0	0.4	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	0.3	PID ALK2 PATHWAY	ALK2 signaling events
0.0	0.2	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	0.2	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	0.2	PID TRAIL PATHWAY	TRAIL signaling pathway

Showing 1 to 7 of 7 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.0	0.7	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.0	0.5	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	0.4	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.4	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0	0.3	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.1	0.2	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	0.2	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.2	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.1	REACTOME ACYL CHAIN REMODELLING OF PG	Genes involved in Acyl chain remodelling of PG

Showing 1 to 10 of 11 entries

Results for bcl6aa+bcl6ab+bcl6b

Z-value: 1.02

Motif logo

Transcription factors associated with bcl6aa+bcl6ab+bcl6b

Activity-expression correlation:

Activity profile of bcl6aa+bcl6ab+bcl6b motif

Sorted Z-values of bcl6aa+bcl6ab+bcl6b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of bcl6aa+bcl6ab+bcl6b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: