ISMARA results: barhl1a+barhl1b

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PRJNA207719: Tissue specific transcriptome profiling

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Results for barhl1a+barhl1b

Z-value: 1.70

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Transcription factors associated with barhl1a+barhl1b

Gene Symbol	Gene ID	Gene Info
barhl1b NCBI UniProt	ENSDARG00000019013	BarH-like homeobox 1b
barhl1a NCBI UniProt	ENSDARG00000035508	BarH-like homeobox 1a
barhl1a NCBI UniProt	ENSDARG00000110061	BarH-like homeobox 1a
barhl1a NCBI UniProt	ENSDARG00000112355	BarH-like homeobox 1a
barhl1b NCBI UniProt	ENSDARG00000113145	BarH-like homeobox 1b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
barhl1a	dr11_v1_chr5_-_29750377_29750377	0.19	7.6e-01	Click!
barhl1b	dr11_v1_chr21_-_17482465_17482465	0.09	8.8e-01	Click!

Activity profile of barhl1a+barhl1b motif

Sorted Z-values of barhl1a+barhl1b motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr24_-_4765740 Show fit	0.78	ENSDART00000121576	cpb1 NCBI UniProt Show fit	carboxypeptidase B1 (tissue)
chr23_+_35713557 Show fit	0.75	ENSDART00000123518	tuba1c NCBI UniProt Show fit	tubulin, alpha 1c
chr19_-_5380770 Show fit	0.68	ENSDART00000000221	krt91 NCBI UniProt Show fit	keratin 91
chr22_+_11756040 Show fit	0.65	ENSDART00000105808	krt97 NCBI UniProt Show fit	keratin 97
chr2_-_32387441 Show fit	0.63	ENSDART00000148202	ubtfl NCBI UniProt Show fit	upstream binding transcription factor, like
chr24_-_41797681 Show fit	0.60	ENSDART00000169643	arhgap28 NCBI UniProt Show fit	Rho GTPase activating protein 28
chr25_-_20666328 Show fit	0.53	ENSDART00000098076	csk NCBI UniProt Show fit	C-terminal Src kinase
chr16_+_49601838 Show fit	0.47	ENSDART00000168570 ENSDART00000159236	si:dkey-82o10.4 NCBI UniProt Show fit	si:dkey-82o10.4
chr23_+_19813677 Show fit	0.47	ENSDART00000139192 ENSDART00000142308	emd NCBI UniProt Show fit	emerin (Emery-Dreifuss muscular dystrophy)
chr11_+_6136220 Show fit	0.46	ENSDART00000082223	tax1bp3 NCBI UniProt Show fit	Tax1 (human T-cell leukemia virus type I) binding protein 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of barhl1a+barhl1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.1	GO:0006011	UDP-glucose metabolic process(GO:0006011)
0.0	0.6	GO:0051098	regulation of binding(GO:0051098)
0.2	0.5	GO:2000008	regulation of protein localization to cell surface(GO:2000008) negative regulation of protein localization to cell surface(GO:2000009)
0.1	0.5	GO:0036306	embryonic heart tube elongation(GO:0036306)
0.1	0.5	GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060368)
0.1	0.5	GO:0051204	protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979) protein insertion into mitochondrial membrane(GO:0051204)
0.0	0.5	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.1	0.4	GO:0030521	androgen receptor signaling pathway(GO:0030521) regulation of androgen receptor signaling pathway(GO:0060765)
0.1	0.4	GO:1901207	regulation of heart looping(GO:1901207)
0.0	0.4	GO:0032488	Cdc42 protein signal transduction(GO:0032488)

Showing 1 to 10 of 81 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.3	GO:0005882	intermediate filament(GO:0005882)
0.1	0.5	GO:0046695	SLIK (SAGA-like) complex(GO:0046695)
0.0	0.4	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0	0.4	GO:0005680	anaphase-promoting complex(GO:0005680)
0.1	0.3	GO:0005968	Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0	0.3	GO:0072546	ER membrane protein complex(GO:0072546)
0.0	0.3	GO:0000930	gamma-tubulin complex(GO:0000930)
0.0	0.3	GO:0000124	SAGA complex(GO:0000124)
0.0	0.3	GO:1990246	uniplex complex(GO:1990246)
0.0	0.3	GO:0000815	ESCRT III complex(GO:0000815)

Showing 1 to 10 of 35 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.3	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.2	1.1	GO:0003983	UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.0	0.8	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.7	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.0	0.6	GO:0031491	nucleosome binding(GO:0031491)
0.1	0.5	GO:0061656	SUMO conjugating enzyme activity(GO:0061656)
0.1	0.5	GO:0043998	H2A histone acetyltransferase activity(GO:0043998)
0.1	0.4	GO:0035173	histone kinase activity(GO:0035173)
0.1	0.4	GO:0070888	E-box binding(GO:0070888)
0.0	0.4	GO:0051117	ATPase binding(GO:0051117)

Showing 1 to 10 of 52 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
1.1	ST B CELL ANTIGEN RECEPTOR	B Cell Antigen Receptor
0.6	PID MYC PATHWAY	C-MYC pathway
0.5	PID BARD1 PATHWAY	BARD1 signaling events
0.4	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.4	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.3	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.3	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.3	PID EPHA FWDPATHWAY	EPHA forward signaling
0.3	PID ILK PATHWAY	Integrin-linked kinase signaling
0.2	PID S1P S1P4 PATHWAY	S1P4 pathway

Showing 1 to 10 of 14 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	0.7	REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0	0.6	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1	0.5	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.0	0.4	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.0	0.3	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.0	0.3	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.0	0.3	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.0	0.3	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	0.3	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling

Showing 1 to 10 of 21 entries

Results for barhl1a+barhl1b

Z-value: 1.70

Motif logo

Transcription factors associated with barhl1a+barhl1b

Activity-expression correlation:

Activity profile of barhl1a+barhl1b motif

Sorted Z-values of barhl1a+barhl1b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of barhl1a+barhl1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: